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公开(公告)号：US20080152660A1
公开(公告)日：2008-06-26
申请号：US11817668
申请日：2006-03-03
Applicant: Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
Inventor： Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
IPC: A61K39/395 , C07K7/00 , A61K38/08
CPC classification number: C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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2.发明授权Methods of treating a disease or condition associated with abnormal angiogenesis 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US08912148B2
公开(公告)日：2014-12-16
申请号：US13584721
申请日：2012-08-13
Applicant: Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
Inventor： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC: A61K38/10 , C07K14/00 , C07K14/515 , A61K38/00
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
Abstract translation: 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
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公开(公告)号：US20110087010A1
公开(公告)日：2011-04-14
申请号：US12897594
申请日：2010-10-04
Applicant: Curt W. BRADSHAW , Venkata Ramana DOPPALAPUDI , Jing-Yu LAI , John RIZZO
Inventor： Curt W. BRADSHAW , Venkata Ramana DOPPALAPUDI , Jing-Yu LAI , John RIZZO
IPC: C07K16/00 , C07D205/08
CPC classification number: C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：US20100003267A1
公开(公告)日：2010-01-07
申请号：US12432528
申请日：2009-04-29
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K39/395 , C07K14/00 , C07K19/00
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
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公开(公告)号：US20120321591A1
公开(公告)日：2012-12-20
申请号：US13595250
申请日：2012-08-27
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K38/18 , A61P35/00 , A61P19/02 , A61P9/12 , A61P13/12 , A61K38/21 , A61P27/06 , A61K39/395 , A61K33/36 , A61K38/50 , A61K33/24 , A61P27/02 , A61P17/06
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules
Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管生成相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽
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Patent Agency Ranking
6.发明申请METHODS OF TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US20120301431A1
公开(公告)日：2012-11-29
申请号：US13584721
申请日：2012-08-13
Applicant: Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
Inventor： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC: A61K38/17 , A61K39/395 , A61K38/50 , A61K33/24 , A61P35/02 , A61P19/02 , A61P17/06 , A61P27/02 , A61P35/00 , A61K39/44 , A61K38/21
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
Abstract translation: 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
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公开(公告)号：US07521425B2
公开(公告)日：2009-04-21
申请号：US11368338
申请日：2006-03-03
Applicant: Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
Inventor： Curt W. Bradshaw , Venkata Ramana Doppalapudi , Jing-Yu Lai , John Rizzo
IPC: A61K38/04
CPC classification number: C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：US20080166364A1
公开(公告)日：2008-07-10
申请号：US11938766
申请日：2007-11-12
Applicant: Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi
Inventor： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi
IPC: A61K39/395 , C07K14/00 , A61P35/04 , C12N5/00 , C07K16/00
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：US08293714B2
公开(公告)日：2012-10-23
申请号：US12432528
申请日：2009-04-29
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K38/16
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
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公开(公告)号：US20080262249A1
公开(公告)日：2008-10-23
申请号：US11660417
申请日：2005-08-16
Applicant: Jeffrey P. Whitten , Jing-Yu Lai
Inventor： Jeffrey P. Whitten , Jing-Yu Lai
IPC: C07D493/02
CPC classification number: A61K31/4745 , C07D311/86 , C07D493/04
Abstract: Methods of making chiral psorospermin or its analogues and/or intermediates thereof are provided.
Abstract translation: 提供了制备手性磷灰石或其类似物和/或其中间体的方法。
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