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    2-(1H) quinolinone compounds
    2.
    发明授权
    2-(1H) quinolinone compounds 失效
    2-（1H）喹啉酮化合物

    公开(公告)号：US5776949A

    公开(公告)日：1998-07-07

    申请号：US889920

    申请日：1997-07-10

    申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    IPC分类号： A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D215/36 ,  C07D401/04 ,  C07D471/04 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D215/36 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D471/04

    摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.

    摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者， 当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与 药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。

    2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds having antihypoxic and nootropic effects
    4.
    发明授权
    2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds having antihypoxic and nootropic effects 失效
    具有抗缺氧和诱导作用的2-（2,3-二氢-2-氧代-3-苯并呋喃基）乙酸化合物

    公开(公告)号：US4859700A

    公开(公告)日：1989-08-22

    申请号：US155352

    申请日：1988-02-12

    申请人： Gilbert Lavielle ,  Jean Lepagnol

    发明人： Gilbert Lavielle ,  Jean Lepagnol

    IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/415 ,  A61P3/00 ,  A61P25/28 ,  C07D307/83 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12

    CPC分类号： C07D405/12 ,  C07D307/83 ,  C07D407/12

    摘要： The invention relates to new 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds of general formula I: ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms or a phenyl radical optionally substituted with a halogen atom or with an alkoxy radical containing 1 to 4 carbon atoms or an alkyl radical having 1 to 4 carbon atoms,R.sub.2 denotes a hydrogen or halogen atom, a hydroxyl radical, an alkyl radical having 1 to 4 carbon atoms or an alkoxy radical containing 1 to 4 carbon atoms,R denotes a hydroxyl radical, a linear or branched alkoxy radical having 1 to 4 carbon atoms, a benzyloxy radical or a radical of general formula A: ##STR2## in which: X and Y, which may be identical or different, each denote a linear or branched alkyl radical containing 1 to 5 carbon atoms, a radical of general formula A.sub.1 (CHZ--COOH)--, in which Z denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms, a hydroxyalkyl radical having 1 to 4 carbon atoms, a 4-imidazolylmethylene radical or a benzyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms or with a hydroxyl radical; a radical of general formula A.sub.2 (CH.sub.2 W)- in which W denotes a linear or branches dialkylaminomethylene radical having 3 to 9 carbon atoms, a 2-pyrrolidinyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms, a benzyl radical, a 1-isochromanyl radical or a 1-isoquinolyl radical, or form, together with the nitrogen to which they are attached, a 2-carboxy-2-pyrrolidinyl radical, a 4-morpholinyl radical, a piperidino radical optionally substituted with a phenyl radical or with an alkoxyphenyl radical having 7 to 10 carbon atoms, or a 1-piperazinyl radical. Medicinal products.

    摘要翻译： 本发明涉及通式I的新的2-（2,3-二氢-2-氧代-3-苯并呋喃基）乙酸化合物：其中：R 1表示氢原子，直链或支链烷基 具有1至4个碳原子的基团或任选被卤素原子或含有1至4个碳原子的烷氧基或具有1至4个碳原子的烷基的苯基，R 2表示氢或卤素原子，羟基 ，具有1至4个碳原子的烷基或含有1至4个碳原子的烷氧基，R表示羟基，具有1至4个碳原子的直链或支链烷氧基，苄氧基或通式A的基团 （A）其中：X和Y可以相同或不同，各自表示含有1至5个碳原子的直链或支链烷基，通式A1（CHZ-COOH） - 的基团，在 其中Z表示氢原子，具有1至4个碳原子的直链或支链烷基，羟烷基 具有1至4个碳原子的基团，4-咪唑基亚甲基或任选被具有1至4个碳原子的烷基或羟基自由基取代的苄基; 通式A2（CH2W）的基团，其中W表示具有3至9个碳原子的直链或支链二烷基氨基亚甲基，任选被具有1至4个碳原子的烷基取代的2-吡咯烷基，苄基， 或与其连接的氮一起形成2-羧基-2-吡咯烷基，4-吗啉基，任选被苯基取代的哌啶子基或 具有7至10个碳原子的烷氧基苯基或1-哌嗪基。 药用产品。

    Tetrahydroquinoline morpholine compounds, compositions and use
    5.
    发明授权
    Tetrahydroquinoline morpholine compounds, compositions and use 失效
    四氢喹啉吗啉化合物，组成和用途

    公开(公告)号：US4782054A

    公开(公告)日：1988-11-01

    申请号：US164103

    申请日：1988-03-04

    申请人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol

    发明人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol

    IPC分类号： A61K31/535 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P25/28 ,  C07D413/12

    CPC分类号： C07D413/12 ,  Y10S514/878 ,  Y10S514/879

    摘要： Morpholine compounds of the formula: ##STR1## in which R.sub.1 is hydrogen, straight-chain or branched (C.sub.1 -C.sub.6)-alkyl which may contain a double bond, aralkyl which may be substituted, (C.sub.5 -C.sub.6)-cycloalkyl or (C.sub.2 -C.sub.6)-acyl; andR.sub.2 is hydrogen, straight-chain or branched (C.sub.1 -C.sub.6)-alkyl which may contain a double bond, aralkyl which may be substituted, or (C.sub.2 -C.sub.3)-acyl; enantiomers and physiologically tolerable acid salts thereof.These compounds may be used therapeutically especially in the treatment of ischaemic syndromes and of cerebral ageing.

    摘要翻译： 其中R 1是氢，可以含有双键的直链或支链（C 1 -C 6） - 烷基，可被取代的芳烷基，（C 5 -C 6） - 环烷基或（C 2 -C 6） -C 6） - 酰基; 和R 2是氢，可以含有双键的直链或支链（C 1 -C 6） - 烷基，可被取代的芳烷基或（C 2 -C 3） - 酰基; 对映体和其生理上可耐受的酸盐。 这些化合物可以治疗特别用于治疗缺血综合征和脑衰老。

    Antihypoxemic 5-(4-substituted piperazinyl)alkyl-8-substituted quinolines
    9.
    发明授权
    Antihypoxemic 5-(4-substituted piperazinyl)alkyl-8-substituted quinolines 失效
    抗低氧5-（4-取代哌嗪基）烷基-8-取代的喹啉

    公开(公告)号：US4629728A

    公开(公告)日：1986-12-16

    申请号：US686247

    申请日：1984-12-26

    申请人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol

    发明人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61K31/675 ,  A61P3/00 ,  A61P7/06 ,  C07D215/26 ,  C07D215/32 ,  C07D215/58 ,  C07D401/12 ,  C07D417/12 ,  C07F9/6509 ,  C07F9/6558 ,  C07D401/06

    CPC分类号： C07D401/12 ,  C07D215/26 ,  C07D417/12 ,  C07F9/65586

    摘要： Quinoline compounds of the formula: ##STR1## in which: ##STR2## represents a group of the formula: ##STR3## in which: R' is hydrogen or methyl,R and R" which are the same or different, each represents: hydrogen, (C.sub.1 -C.sub.5) alkyl, (C.sub.1 -C.sub.5) acyl haloacyl or aminoacyl, (C.sub.1 -C.sub.3) alkylsulfonyl, or diethylphosphonyl;n is an integer form 1 to 4 inclusive;T is phenyl, halophenyl, trifluoromethylphenyl [(C.sub.1 -C.sub.5) alkyl] phenyl, [(C.sub.1 -C.sub.5) alkoxy] phenyl, or a five or six-membered heterocyclic radical containing one or two atoms selected from nitrogen and sulfur atoms optionally substituted by one or more (C.sub.1 -C.sub.5) alkyl or (C.sub.1 -C.sub.5) alkoxy.These compounds and physiologically tolerable acid addition salts thereof may be used a medicines especially in the treatment of disorders connected with hypoxemia and energetic metabolic insufficiency especially during cerebral aging.

    摘要翻译： 喹啉化合物，其结构式如下：其中：表示下式的基团：其中：R'为氢或甲基，R和R“相同或不同，各自表示： 氢，（C1-C5）烷基，（C1-C5）酰基卤代酰基或氨基酰基，（C1-C3）烷基磺酰基或二乙基膦酰基; n为1〜4的整数， T是苯基，卤代苯基，三氟甲基苯基[（C 1 -C 5）烷基]苯基，[（C 1 -C 5）烷氧基]苯基或含有一个或两个选自氮和硫原子的原子的五或六元杂环基， （C1-C5）烷基或（C1-C5）烷氧基。 这些化合物和其生理上可耐受的酸加成盐可以用于特别是用于治疗与低氧血症和高能代谢功能不全相关的疾病的药物，特别是在脑衰老期间。