PREVENTION OF ACCUMULATED TOLERANCE TO STIMULANT MEDICATION FOR THE TREATMENT OF ADHD

    公开(公告)号:US20220409557A1

    公开(公告)日:2022-12-29

    申请号:US17716932

    申请日:2022-04-08

    Abstract: It is proposed that dissipation of relative benefit during long-term treatment is due to long-term tolerance to stimulant medications. To improve adherence and persistence of medication use, it is advantageous to develop medications that are not undermined by long-term tolerance. Disclosed herein in certain implementations are formulations and methods relating to an alternative formulation of medication for the treatment of ADHD based on two principles: (a) retaining the initial immediate-release component of controlled-release formulations that targets a neural mechanism, which elicits acute tolerance, and (b) replacing the subsequent sustained-release component with a medication that maintains the initial benefit by targeting a different neural mechanism does not elicit tolerance, thus allowing more time for acute tolerance elicited by the initial bolus dose of stimulant medication to dissipate completely each day and avoid carry-over and accumulation that results in long-term tolerance.

    Asymmetric shock absorption for footwear

    公开(公告)号:US11253025B2

    公开(公告)日:2022-02-22

    申请号:US15884656

    申请日:2018-01-31

    Inventor: Lee James Martin

    Abstract: A system and a method of asymmetric shock absorption and torsion cushioning for footwear. The asymmetric shock absorption system providing an upper plate attached to the upper section of the footwear and a lower plate attached to the lower section of the footwear. The upper plate may be in direct contact with or spaced apart from the lower plate. A flexible perimeter band extends around the entire perimeter of the sole of the footwear and permanently connects the upper section to the lower section of the footwear. The flexible perimeter band may have a low-profile and extend around only the perimeter of the upper and lower plates. The flexible perimeter band may wrap around one or more plate to provide for limited horizontal movement, e.g., lateral, longitudinal, or both lateral and longitudinal, between the upper section of the footwear and the lower section of the footwear.

    Sloped soap holder
    5.
    发明授权

    公开(公告)号:US10357132B1

    公开(公告)日:2019-07-23

    申请号:US15682035

    申请日:2017-08-21

    Applicant: James Martin

    Inventor: James Martin

    Abstract: A sloped soap holder including a rectangular base unit and a plurality of foot members disposed on a bottom surface of the rectangular base unit. A single continuous sloped soap platform is disposed on a top surface of the rectangular base unit. Each of a right pair and a left pair of a plurality of a pair of vertically disposed X-shaped side supports has a lower surface disposed on the top surface of the rectangular base unit and an inner surface attached to each of the right edge and the left edge, respectively, of the sloped soap platform. Each of a plurality of drain openings and a plurality of linear grooves is disposed within the sloped soap platform. A plurality of raised diagonally disposed linear tracks is also disposed on the sloped soap platform.

    SYSTEMS AND METHODS TO ESTIMATE HUMAN LENGTH

    公开(公告)号:US20190125215A1

    公开(公告)日:2019-05-02

    申请号:US16174940

    申请日:2018-10-30

    Abstract: Systems and methods use a three-dimensional snapshot of an infant, child, adolescent, or adult where the subject may have bent legs and an unaligned head position, to provide an estimate of human length. The system identifies anatomical features from the digital information and generates a virtual skeleton. The cumulative distances between pseudo-joints of the virtual skeleton provide an estimate of human length. Comparing length estimates from multiple three-dimensional snapshots of the same individual acquired over time provide an indication of growth of the infant, child, or adolescent. Daily estimates of length can detect growth faltering sooner than less frequent estimates of length, which can lead to timely intervention.

    FOOTWEAR WITH PERFORMANCE MEASUREMENT DEVICE
    8.
    发明申请
    FOOTWEAR WITH PERFORMANCE MEASUREMENT DEVICE 审中-公开
    具有性能测量设备的鞋子

    公开(公告)号:US20160219968A1

    公开(公告)日:2016-08-04

    申请号:US15009403

    申请日:2016-01-28

    Abstract: Footwear for an individual such as a cyclist is provided with a performance measurement device for measuring the individual's performance. A first exemplary article of such footwear includes a shoe in combination with an optional means for substantially immobilizing the shoe to a pedal of a cycle, e.g., a cleat, and the performance measurement device. A second exemplary article of such footwear is a sock in combination with the measurement device. Typically, the measurement device is embedded or located within the footwear and is not mounted to an exterior surface, e.g., the bottom sole surface, of the footwear.

    Abstract translation: 针对诸如骑自行车者的个人的鞋子设置有用于测量个人的表现的表现测量装置。 这种鞋类的第一示例性制品包括与用于将鞋基本上固定到例如防滑钉的踏板上的可选装置的靴子以及性能测量装置。 这种鞋类的第二示例性物品是与测量装置组合的袜子。 通常,测量装置嵌入或位于鞋类内部,并且不安装到鞋类的外表面,例如底部底部表面。

    Thin film capacitors
    9.
    发明授权
    Thin film capacitors 有权
    薄膜电容器

    公开(公告)号:US09406444B2

    公开(公告)日:2016-08-02

    申请号:US13289194

    申请日:2011-11-04

    CPC classification number: H01G7/06 H01G4/33 H01G4/38 H03H2001/0014 H04B1/0458

    Abstract: A system that incorporates teachings of the present disclosure may include, for example, a first solid electrode, a second electrode separated into subsections, and a dielectric medium separating the subsections from the first solid electrode, where the subsections of the second electrode include a first group of subsections and a second group of subsections, where the first group of subsections are connectable with a first terminal for receiving an input signal, and where the second group of subsections is connectable with a second terminal for providing an output signal. Other embodiments are disclosed.

    Abstract translation: 结合本公开的教导的系统可以包括例如第一固体电极,分成子部分的第二电极和将第一电极的子部分分开的电介质,其中第二电极的子部分包括第一固体电极 小组组和第二组子部分,其中第一组子部分可与用于接收输入信号的第一终端连接,并且其中第二组子部分可与第二终端连接以提供输出信号。 公开了其他实施例。

    MEDICINAL MYCOLOGICAL PREPARATIONS HAVING IMPROVED POTENCY
    10.
    发明申请
    MEDICINAL MYCOLOGICAL PREPARATIONS HAVING IMPROVED POTENCY 审中-公开
    具有改善的药物的药物制剂制剂

    公开(公告)号:US20160206670A1

    公开(公告)日:2016-07-21

    申请号:US14599373

    申请日:2015-01-16

    CPC classification number: A61K36/07 A61K2236/00

    Abstract: The invention provides medicinal fungal preparations that have twenty or more times more medicinal potency than corresponding medicinal fungal preparations made by prevailing means in the prior art. In particular the invention provides nutrient-supplemented bioactive cell-ruptured cultures of medicinal fungi for which the post-rupture extraction medium is edible or potable, and has no significant side effects. The invention further provides methods to prepare them, and pharmacological preparations based on whole-culture biomass including the growth medium and metabolites.

    Abstract translation: 本发明提供药用真菌制剂,其具有比现有技术中主要方法制备的相应药用真菌制剂的药效更多二十倍以上。 特别地,本发明提供了药用真菌的营养补充的生物活性细胞破裂培养物,其中破裂后提取培养基可食用或饮用,并且没有显着的副作用。 本发明还提供了制备它们的方法,以及基于全培养生物质(包括生长培养基和代谢物)的药物制剂。

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