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1.发明授权公开(公告)号：US08148369B2
公开(公告)日：2012-04-03
申请号：US12151585
申请日：2008-05-07
申请人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Giovanni Alessandro Tricarico , Grégory Louis Joseph Bar , Kim Louise Hirst , Olga Raquel Pinto Santos Oliveira Roussel , Juha Andrew Clase
发明人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Giovanni Alessandro Tricarico , Grégory Louis Joseph Bar , Kim Louise Hirst , Olga Raquel Pinto Santos Oliveira Roussel , Juha Andrew Clase
IPC分类号： A61K31/50 , A61K31/535 , C07D413/14 , C07D471/04
CPC分类号： C07D487/04
摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
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2.发明申请TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES 失效用于治疗变应性和炎症性疾病的三唑吡嗪化合物公开(公告)号：US20100298300A1
公开(公告)日：2010-11-25
申请号：US12399979
申请日：2009-03-08
申请人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
发明人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/519 , C07D487/04 , C07D243/08 , A61P29/00 , A61P19/02 , A61P9/10 , A61P9/00
CPC分类号： C07D487/04
摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.
摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。
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3.发明申请Fused Pyrazine Compounds Useful for the Treatment of Degenerative and Inflammatory Diseases 审中-公开用于治疗退行性和炎性疾病的熔融吡嗪化合物公开(公告)号：US20120232075A1
公开(公告)日：2012-09-13
申请号：US13411450
申请日：2012-03-02
申请人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Giovanni Alessandro Tricarico , Grégory Louis Joseph Bar , Kim Louise Hirst , Olga Raquel Pinto Santos Oliveira Roussel , Juha Andrew Clase
发明人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Giovanni Alessandro Tricarico , Grégory Louis Joseph Bar , Kim Louise Hirst , Olga Raquel Pinto Santos Oliveira Roussel , Juha Andrew Clase
IPC分类号： A61K31/4985 , A61K31/5377 , A61P29/00 , A61P19/02 , A61P19/10 , A61P19/04 , A61P1/02 , A61P35/04 , A61P11/00 , A61P11/06 , A61P13/12 , A61P1/16 , A61P9/10 , A61P9/04 , A61P25/00 , C07D487/04
CPC分类号： C07D487/04
摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如炎症，类风湿关节炎等。
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4.发明授权Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases 有权用于治疗退行性和炎性疾病的吡唑嗪化合物公开(公告)号：US08138193B2
公开(公告)日：2012-03-20
申请号：US12753383
申请日：2010-04-02
申请人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
发明人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
IPC分类号： A61K31/4965
CPC分类号： C07D487/04
摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
摘要翻译： 公开了具有由以下表示的式的新型稠合吡嗪化合物：如书面描述中所定义的Z，R 1，R 2，R 8和R 9。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎症，类风湿性关节炎等。
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5.发明授权Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases 有权用于治疗退行性和炎性疾病的吡唑嗪化合物公开(公告)号：US08133895B2
公开(公告)日：2012-03-13
申请号：US12151586
申请日：2008-05-07
申请人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
发明人： Martin James Inglis Andrews , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
IPC分类号： A61K31/4965
CPC分类号： C07D487/04
摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如，炎症，类风湿关节炎等。
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6.发明授权Substituted triazolopyrazines useful for the treatment of degenerative and inflammatory diseases 失效用于治疗退行性和炎性疾病的取代三唑并吡嗪公开(公告)号：US08012983B2
公开(公告)日：2011-09-06
申请号：US12436219
申请日：2009-05-06
申请人： Martin James Inglis Andrews , Mark Stuart Chambers , Hervé Van De Poël , Grégory Louis Joseph Bar
发明人： Martin James Inglis Andrews , Mark Stuart Chambers , Hervé Van De Poël , Grégory Louis Joseph Bar
IPC分类号： A61K31/4965
CPC分类号： C07D519/00
摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.
摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪和咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可以使用 用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症等。
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7.发明授权Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases 失效可用于治疗退行性和炎性疾病的三唑并吡嗪化合物公开(公告)号：US07915256B2
公开(公告)日：2011-03-29
申请号：US12399979
申请日：2009-03-08
申请人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
发明人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
IPC分类号： C07D403/12 , A61K31/506
CPC分类号： C07D487/04
摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.
摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。
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8.发明申请FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 有权用于治疗变应性和炎症性疾病的融合的吡嗪化合物公开(公告)号：US20100240666A1
公开(公告)日：2010-09-23
申请号：US12753383
申请日：2010-04-02
申请人： Martin James Inglis ANDREWS , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
发明人： Martin James Inglis ANDREWS , Mark Stuart Chambers , Wolfgang Schmidt , Grégory Louis Joseph Bar
IPC分类号： A61K31/4985 , C07D471/04 , A61P19/02
CPC分类号： C07D487/04
摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
摘要翻译： 公开了具有由以下表示的式的新型稠合吡嗪化合物：如书面描述中所定义的Z，R 1，R 2，R 8和R 9。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎症，类风湿性关节炎等。
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9.发明授权Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases 失效可用于治疗退行性和炎性疾病的三唑并吡嗪化合物公开(公告)号：US07501411B2
公开(公告)日：2009-03-10
申请号：US11809294
申请日：2007-05-30
申请人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
发明人： Martin James Inglis Andrews , Paul Edwards , Mark Stuart Chambers , Wolfgang Schmidt , Juha Andrew Clase , Gregory Bar , Kim Louise Hirst , Angus MacLeod
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04
摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.
摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。
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10.发明授权公开(公告)号：US08178530B2
公开(公告)日：2012-05-15
申请号：US12970632
申请日：2010-12-16
申请人： Martin James Inglis Andrews , Paul Edwards , Reginald Christophe Xavier Brys , Philip Huxley , Wolfgang Schmidt , Veronique Birault , Mark Stuart Chambers , Clifford John Harris , Angus MacLeod , Kim Louise Hirst , Juha Andrew Clase , Gregory Bar
发明人： Martin James Inglis Andrews , Paul Edwards , Reginald Christophe Xavier Brys , Philip Huxley , Wolfgang Schmidt , Veronique Birault , Mark Stuart Chambers , Clifford John Harris , Angus MacLeod , Kim Louise Hirst , Juha Andrew Clase , Gregory Bar
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04
摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
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