Abstract:
The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I).
Abstract:
A web service for pre-caching web content on a mobile device includes receiving a request from the mobile device for first web content, fetching the first web content, determining second web content to pre-fetch based upon the first web content, fetching the second web content, and causing the second web content to be stored in a content cache on the mobile device responsive to the request for the first web content. Pre-caching web content in this manner provides web content to the mobile device that the user of the mobile device is likely to access. Pre-caching of additional web content prior to receiving an explicit request improves web browsing performance of the mobile device.
Abstract:
A load-bearing medical implant is disclosed that includes a load-bearing structure with a cavity extending into the outer surface of the structure. The cavity accommodates a sensor that is held in a fixed position within the cavity by an encapsulant. The cavity is covered by a plate that is welded over the cavity in close proximity to the sensor and encapsulant to provide a seal over the cavity and the electronic component without causing thermal damage to the encapsulant or sensor despite the close proximity of the encapsulant and sensor to the welded areas of the plate and structure. Methods for encapsulating the sensor in the cavity, methods for encapsulating a wire bus leading from the sensor through a channel in the implant and methods for pulsed laser welding of weld plate over the sensor and encapsulant with thermal damage to either are disclosed.
Abstract:
A communications system may include a plurality of client devices configured to generate client processing jobs, each having a respective unique client ID associated therewith. A plurality of geographically spaced apart servers may be configured to process the client processing jobs, each having a respective unique server ID associated therewith. A load balancer may be configured to receive the client processing jobs from the plurality of client devices, and for each client processing job, generate a respective load balancing score for each server based upon the client ID of the client device requesting the client processing job, the server ID of each server, a processing load metric for each server, and a separation metric corresponding to a separation between the requesting client device and each server. The load balancer may also be configured to assign each client processing job to a respective server based upon the load balancing scores.
Abstract:
A sports equipment hand-held or stick-held carrier that weaves or threads through one or more pieces of equipment and holds a ball, mouthpiece and other miscellaneous items. The carrier slides, snaps or hooks onto a lacrosse stick and has a strap for hands-free carrying of all the necessary pieces of equipment. The carrier binds the stick and equipment together over the shoulder and around the torso of the user. The stick is easily inserted and removed from the carrier for play while holding the equipment together. This carrier acts as a needle and thread that easily holds and releases the various pieces of equipment. It is a quick, open and secure way to store or carry equipment on its own separately or attached to a stick. The carrier can also be customized with removable attachments to create varying combinations to accommodate different players and easily replace any broken parts.
Abstract:
Certain TRPV1-modulating thiazolopyrimidine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
Abstract:
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
Abstract:
An authentication server and methods of generating a token for use by a mobile device to establish authorization for the mobile device to access a service provided by a service server, the method comprising receiving a request for the token from the mobile device, generating the token comprising location data identifying a location for the mobile device and authentication data indicating a level of access that the mobile device is permitted to have to the service provided by the service server, and transmitting the token to the mobile device.
Abstract:
The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I)