-
公开(公告)号：US08968373B2
公开(公告)日：2015-03-03
申请号：US12179471
申请日：2008-07-24
IPC分类号： A61B17/04 , A61B17/56 , A61B17/58 , A61B17/86 , A61F2/08 , A61F2/30 , A61C8/02 , A61B17/00 , A61C8/00
CPC分类号： A61B17/8605 , A61B17/863 , A61B17/866 , A61B2017/00893 , A61B2017/8655 , A61C8/0006 , A61C8/001
摘要： An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.
摘要翻译： 提供了一种用于在骨移植过程中保持水平和/或垂直空间的可植入螺钉系统，所述螺钉包括：具有适于支撑软组织并允许骨生长的区域的成型头部; 螺纹轴和适于穿透骨组织的尖端; 并且其中一个螺钉包含用于接合第二螺钉的螺纹室，用于额外的空间维护; 其中所述螺钉包括皮质骨材料。 公开了在骨格栅手术期间植入一个或多个螺钉的方法。
-
公开(公告)号：US20120178781A1
公开(公告)日：2012-07-12
申请号：US13408309
申请日：2012-02-29
申请人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/4535 , A61K31/453 , A61P25/06 , A61P37/02 , A61P37/06 , A61P19/02 , A61P37/08 , A61P31/12 , A61P1/12 , A61P25/18 , A61P25/24 , A61P11/14 , A61P25/30 , A61P9/12 , A61P3/04 , A61P25/08 , C07D211/08
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对κ阿片样物质受体的功能性结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样物质受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的应用。
-
公开(公告)号：US08173678B2
公开(公告)日：2012-05-08
申请号：US12911244
申请日：2010-10-25
申请人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/451 , A61K31/453 , C07D227/06 , C07D471/18 , C07D211/18 , C07D401/12
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
-
公开(公告)号：US20100190746A1
公开(公告)日：2010-07-29
申请号：US12623357
申请日：2009-11-20
IPC分类号： A61K31/695 , C07D239/95 , A61K31/517 , C07D401/12 , C07F7/10 , C07D495/04 , A61K31/519 , C07D471/04 , C07D473/22 , A61K31/522 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/08 , A61P35/00 , A61P27/00 , A61P25/28 , A61P27/06 , A61P9/10 , A61P25/22 , C12N5/071
CPC分类号： C07D401/12 , A61K31/495 , C07D239/95 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
摘要翻译： 提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。 更具体地，本发明提供可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病性障碍）的喹唑啉酮，组合物和方法 ，癫痫，癫痫，癫痫，听力和视力丧失，阿尔茨海默病，年龄相关的记忆丧失，学习缺陷，焦虑和运动神经元疾病）和作为神经保护剂（例如，通过调节相关的钾通道来预防中风等） 指示条件的发生或复发。
-
公开(公告)号：US20090264462A1
公开(公告)日：2009-10-22
申请号：US12105814
申请日：2008-04-18
IPC分类号： A61K31/4725 , C07D403/12 , A61P43/00
CPC分类号： A61K31/451 , A61K31/4725 , A61K31/485 , C07D401/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
-
公开(公告)号：US06900228B1
公开(公告)日：2005-05-31
申请号：US09623872
申请日：1999-03-09
IPC分类号： C07D211/22 , C07D211/58 , C07D221/08 , C07D221/22 , A61K31/4468
CPC分类号： C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
摘要： The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
摘要翻译： 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
-
公开(公告)号：US06593348B2
公开(公告)日：2003-07-15
申请号：US10100096
申请日：2002-03-19
IPC分类号： A61K31451
CPC分类号： C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
摘要： The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
摘要翻译： 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
-
公开(公告)号：US06552032B2
公开(公告)日：2003-04-22
申请号：US10100097
申请日：2002-03-19
IPC分类号： A61K31473
CPC分类号： C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
摘要： The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
摘要翻译： 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
-
公开(公告)号：US06531481B2
公开(公告)日：2003-03-11
申请号：US10099948
申请日：2002-03-19
IPC分类号： A61K31439
CPC分类号： C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
摘要： The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
-
公开(公告)号：US06276576B1
公开(公告)日：2001-08-21
申请号：US09567111
申请日：2000-05-08
申请人： James B. Thomas
发明人： James B. Thomas
IPC分类号： A47G2580
CPC分类号： A47G25/90
摘要： A tie tucking apparatus for engaging an edge of a segment of a neck tie wrapped around a user shirt collar and for guiding the tie underneath the user shirt collar includes a plate of relatively unyielding material having a tie engaging end including a tie edge engaging slot extending into the plate and defining plate tabs separated by the engaging slot, the plate tabs being spaced apart by the engaging slot. The apparatus preferably additionally includes a collar abutment plate edge, and the collar abutment edge preferably is angled relative to the engaging slot so that the plate narrows at the tie engaging end to fit more easily under a collar. The plate preferably is elongate and has a plate longitudinal axis and two opposing plate longitudinal ends. The engaging slot optionally extends into the plate parallel to the plate longitudinal axis. Each plate longitudinal end preferably is a tie engaging end, so that the plate may be gripped by a user from either plate longitudinal end for use. The plate has two opposing plate faces and preferably at least one of the plate faces retains and displays advertising indicia. The tie engaging end preferably includes several substantially parallel tie edge engaging slots, dividing the tie engaging end into at least three plate tabs.
摘要翻译： 用于接合缠绕在使用者衬衫领上的用于引导用户衬衫领下面的领带的一段领带的边缘的领带折叠装置包括相对不牢固的材料的板，该板具有配合接合端，该接合端包括拉紧边缘接合槽， 进入板和由接合槽分开的限定板片，板突片被接合槽隔开。 该装置优选地另外包括套环邻接板边缘，并且套环邻接边缘优选地相对于接合槽成角度，使得板在接合端部变窄，以更容易地配合在套环下方。 该板优选是细长的并且具有板纵向轴线和两个相对的板纵向端部。 接合槽任选地平行于板纵向轴线延伸到板中。 每个板纵向端部优选地是接合端部，使得板可以由使用者从板纵向端部夹持使用。 板具有两个相对的板面，优选地，至少一个板面保持并显示广告标记。 连接接合端优选地包括几个基本平行的接合边缘接合槽，将接合端分成至少三个板接头。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.041 秒)
