公开(公告)号：US08257743B2

公开(公告)日：2012-09-04

申请号：US12443004

申请日：2007-06-29

申请人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

发明人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

IPC分类号： A61K9/14 ,  A61K33/24

CPC分类号： C08J3/12 ,  A61K9/5153 ,  A61K9/5192 ,  C08J2329/04

摘要： Disclosed herein are multifunctional nanoparticles, comprising: polymer nanoparticles formed by loading a drug into a polymer; a gold thin film deposited on a portion of the surface of the polymer nanoparticles; and an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered, the antibody being conjugated to the gold thin film. Also disclosed is a method for preparing multifunctional nanoparticles, the method comprising the steps of: loading a drug into a polymer to prepare polymer nanoparticles; depositing a portion of the surface of the polymer nanoparticles with a gold thin film; conjugating to the gold thin film an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered; and separating from the resulting nanoparticles those in which a portion of the surface of the polymer nanoparticles is deposited with the gold thin film and conjugated with the antibody. Furthermore, disclosed are a composition containing the multifunctional nanoparticles and a method for diagnosing and treating disease using the composition.

摘要翻译： 本文公开了多功能纳米颗粒，其包括：通过将药物加载到聚合物中形成的聚合物纳米颗粒; 沉积在聚合物纳米颗粒表面的一部分上的金薄膜; 以及针对在药物要被递送的细胞的表面上表达的物质的抗体，所述抗体与金薄膜缀合。 还公开了一种制备多功能纳米颗粒的方法，所述方法包括以下步骤：将药物装载到聚合物中以制备聚合物纳米颗粒; 用金薄膜沉积聚合物纳米颗粒表面的一部分; 与金薄膜缀合对在药物将要递送的细胞表面上表达的物质的抗体; 并从所得到的纳米颗粒中分离，其中聚合物纳米颗粒的一部分表面用金薄膜沉积并与抗体缀合。 此外，公开了含有多功能纳米颗粒的组合物和使用该组合物诊断和治疗疾病的方法。

公开(公告)号：US20110151429A1

公开(公告)日：2011-06-23

申请号：US12681095

申请日：2009-03-31

申请人： Seungjoo Haam ,  Jin-Suck Suh ,  Yong-Min Huh ,  Jaemoon Yang ,  Eun-Kyung Lim ,  Yoonah Kang

发明人： Seungjoo Haam ,  Jin-Suck Suh ,  Yong-Min Huh ,  Jaemoon Yang ,  Eun-Kyung Lim ,  Yoonah Kang

IPC分类号： C12Q1/70 ,  B01J19/00 ,  B05D1/36 ,  G01N33/53 ,  G01N33/574 ,  C12M1/34 ,  G01N33/48

CPC分类号： G01N33/54346 ,  Y10T436/143333

摘要： The present invention relates to a bioprobe including a substrate and inorganic nanoparticles attached to the surface of the substrate, a method of preparing the bioprobe, and an analysis apparatus and method using the bioprobe. In the bioprobe according to the present invention, inorganic nanoparticles introduced to the substrate serve as a linker to which a target-specific substance such as an antibody can be bound, and they also increase the surface area of the substrate, thus increasing a surface area where a target substance to be detected can contact the substrate. In this regard, the bioprobe can be effectively used for detection, dosing, or analysis of various biomolecules or other chemical substances.

摘要翻译： 本发明涉及一种生物探针，其包括底物和附着于基底表面的无机纳米颗粒，生物探针的制备方法以及使用该生物探针的分析装置和方法。 在根据本发明的生物探针中，引入到底物的无机纳米粒子用作能够结合目标特异性物质如抗体的接头，并且还增加了基底的表面积，从而增加了表面积 其中待检测的目标物质可以接触基底。 在这方面，生物探针可以有效地用于各种生物分子或其他化学物质的检测，给药或分析。

公开(公告)号：US20100028453A1

公开(公告)日：2010-02-04

申请号：US12443004

申请日：2007-06-29

申请人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

发明人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

IPC分类号： A61K9/16 ,  A61K39/395

CPC分类号： C08J3/12 ,  A61K9/5153 ,  A61K9/5192 ,  C08J2329/04

摘要： Disclosed herein are multifunctional nanoparticles, comprising: polymer nanoparticles formed by loading a drug into a polymer; a gold thin film deposited on a portion of the surface of the polymer nanoparticles; and an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered, the antibody being conjugated to the gold thin film. Also disclosed is a method for preparing multifunctional nanoparticles, the method comprising the steps of: loading a drug into a polymer to prepare polymer nanoparticles; depositing a portion of the surface of the polymer nanoparticles with a gold thin film; conjugating to the gold thin film an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered; and separating from the resulting nanoparticles those in which a portion of the surface of the polymer nanoparticles is deposited with the gold thin film and conjugated with the antibody. Furthermore, disclosed are a composition containing the multifunctional nanoparticles and a method for diagnosing and treating disease using the composition.

摘要翻译： 本文公开了多功能纳米颗粒，其包括：通过将药物加载到聚合物中形成的聚合物纳米颗粒; 沉积在聚合物纳米颗粒表面的一部分上的金薄膜; 以及针对在药物要被递送的细胞的表面上表达的物质的抗体，所述抗体与金薄膜缀合。 还公开了一种制备多功能纳米颗粒的方法，所述方法包括以下步骤：将药物装载到聚合物中以制备聚合物纳米颗粒; 用金薄膜沉积聚合物纳米颗粒表面的一部分; 与金薄膜缀合对在药物将要递送的细胞表面上表达的物质的抗体; 并从所得到的纳米颗粒中分离，其中聚合物纳米颗粒的一部分表面用金薄膜沉积并与抗体缀合。 此外，公开了含有多功能纳米颗粒的组合物和使用该组合物诊断和治疗疾病的方法。

公开(公告)号：US06706839B1

公开(公告)日：2004-03-16

申请号：US09913231

申请日：2001-12-10

申请人： Craig Stephens Wilcox ,  Jaemoon Yang

发明人： Craig Stephens Wilcox ,  Jaemoon Yang

IPC分类号： C07B6302

CPC分类号： C07C319/28 ,  C07B63/02 ,  C07B2200/09 ,  C07C37/055 ,  C07C37/0555 ,  C07C41/30 ,  C07C209/86 ,  C07C211/52 ,  C07C323/52 ,  C07C43/215 ,  C07C39/21 ,  C07C39/225

摘要： The present invention is directed to partitioning agents and methods of using same to effectuate separation of a reactant, intermediate product, and/or final product from a reaction mixture while minimizing the need for traditional separation or isolation techniques.

摘要翻译： 本发明涉及分配剂及其使用方法，以实现将反应物，中间产物和/或最终产物从反应混合物中分离，同时最小化对传统分离或分离技术的需要。