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公开(公告)号：US20130171177A1
公开(公告)日：2013-07-04
申请号：US13701932
申请日：2011-07-11
申请人： Randolph Corteling , Caroline Hicks , John Sinden , Jack Price
发明人： Randolph Corteling , Caroline Hicks , John Sinden , Jack Price
IPC分类号： A61K35/30
CPC分类号： A61K35/30 , A61K2035/122 , C12N5/0623
摘要： The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders.
摘要翻译： 本发明提供了可从CTX0E03神经干细胞系获得的分离的细胞，其用于治疗与升高水平的促炎细胞因子相关的病症，其中所述病症选自单极性和双相抑郁症，精神分裂症，强迫症， 自闭症和自闭症综合症。
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公开(公告)号：US20050032213A1
公开(公告)日：2005-02-10
申请号：US10493523
申请日：2002-10-25
申请人： John Sinden , Ziping Dong
发明人： John Sinden , Ziping Dong
IPC分类号： C12N15/09 , A61K35/50 , A61K48/00 , A61P43/00 , C07K14/82 , C12N5/10 , C12N9/12 , C12N15/12 , C12N15/54 , C12N15/63 , C12N15/85
CPC分类号： C12N15/85 , A61K35/50 , C07K14/82 , C12N9/1205 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Recombinant vectors or constructs are prepared comprising a polynucleotide that encodes a conditionally-induced oncogene operably linked to the enhancer element of the second intron of the nestin gene, or a functional fragment thereof. The constructs can be used to produce conditionally immortal cells, for transplantation.
摘要翻译： 制备重组载体或构建体，其包含编码与巢蛋白基因的第二内含子的增强子元件可操作地连接的条件诱导的癌基因的多核苷酸或其功能性片段。 该构建体可用于产生条件性永生细胞用于移植。
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公开(公告)号：US20090238799A1
公开(公告)日：2009-09-24
申请号：US12092356
申请日：2006-11-03
申请人： John Sinden , Lara Stevanato , Erik Miljan
发明人： John Sinden , Lara Stevanato , Erik Miljan
CPC分类号： C07K14/721 , C07K14/82 , C12N5/0676 , C12N2503/02 , C12N2510/04 , G01N33/507 , G01N2800/042
摘要： Conditionally immortalized pancreatic cells are produced which remain immortal in the presence of 4-hydroxytamoxifen (4-OHT) but express normal pancreatic cell markers when 4-OHT is not present. The cells therefore permit cell lines to be constructed to produce cells useful for transplantation or in screening assays.
摘要翻译： 产生有条件的永生化胰腺细胞，其在4-羟基他莫昔芬（4-OHT）存在下保持不变，但当不存在4-OHT时表达正常的胰腺细胞标志物。 因此，细胞允许构建细胞系以产生可用于移植或筛选测定的细胞。
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公开(公告)号：US07371374B2
公开(公告)日：2008-05-13
申请号：US11178216
申请日：2005-07-08
CPC分类号： A61K35/30 , A61K35/12 , C12N5/0623 , C12N2500/25 , C12N2500/90 , C12N2501/115 , C12N2501/24 , C12N2501/392 , C12N2501/395 , C12N2501/91
摘要： The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are encompassed by the invention.
摘要翻译： 本发明涉及通过脑内移植多能神经上皮细胞使行为和/或心理缺陷的校正的新方法。 本发明包括细胞，细胞系，药物制剂，药物，用于生产和维持用于本发明方法的细胞系的方法。
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公开(公告)号：US3308971A
公开(公告)日：1967-03-14
申请号：US38852064
申请日：1964-08-10
申请人： ROLAND SINDEN , DEAN SINDEN , JOHN SINDEN
发明人： ROLAND SINDEN , DEAN SINDEN , JOHN SINDEN
IPC分类号： A01D85/00
CPC分类号： A01D85/005 , A01D2085/007
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公开(公告)号：US09629879B2
公开(公告)日：2017-04-25
申请号：US13701932
申请日：2011-07-11
申请人： Randolph Corteling , Caroline Hicks , John Sinden , Jack Price
发明人： Randolph Corteling , Caroline Hicks , John Sinden , Jack Price
IPC分类号： A61K35/30 , C12N5/0797 , A61K35/12
CPC分类号： A61K35/30 , A61K2035/122 , C12N5/0623
摘要： The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders.
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公开(公告)号：US07419827B2
公开(公告)日：2008-09-02
申请号：US11283621
申请日：2005-11-21
申请人： John Sinden , Kenneth Pollock , Paul Stroemer
发明人： John Sinden , Kenneth Pollock , Paul Stroemer
CPC分类号： C12N5/0623 , A61K35/12 , C12N2500/25 , C12N2500/46 , C12N2501/11 , C12N2501/115 , C12N2501/392 , C12N2510/04
摘要： Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.
摘要翻译： 可以通过修饰表达T抗原的基因使其缺少Bub1结合来克服T抗原表达细胞中的基因组不稳定性。 可以通过掺入修饰的T抗原基因，优选与端粒酶构建体的催化亚单位一起产生稳定的细胞系。
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公开(公告)号：US20080131404A1
公开(公告)日：2008-06-05
申请号：US11574437
申请日：2005-09-21
申请人： Deborah Johnson , John Sinden , Peter Goldfarb , Anders Svanberg
发明人： Deborah Johnson , John Sinden , Peter Goldfarb , Anders Svanberg
CPC分类号： C07K14/70567 , C07K14/82 , C07K2319/00 , C07K2319/81 , C12N5/067 , C12N2510/04
摘要： The invention relates to the production of hepatocyte cell lines useful in toxicology screens or therapy. A mammalian hepatocyte comprises, as a single polypeptide, a fusion protein comprising a c-myc protein and an oestrogen receptor, or functional fragments thereof.
摘要翻译： 本发明涉及用于毒理学筛选或治疗的肝细胞细胞系的生产。 哺乳动物肝细胞包含作为单一多肽的包含c-myc蛋白和雌激素受体的融合蛋白或其功能片段。
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公开(公告)号：US20080118479A1
公开(公告)日：2008-05-22
申请号：US12020874
申请日：2008-01-28
申请人： John Sinden , Kenneth Pollock , Paul Stroemer
发明人： John Sinden , Kenneth Pollock , Paul Stroemer
CPC分类号： C12N5/0623 , A61K35/12 , C12N2500/25 , C12N2500/46 , C12N2501/11 , C12N2501/115 , C12N2501/392 , C12N2510/04
摘要： The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302.
摘要翻译： 本发明涉及可从具有ECACC登录号04091601,04110301和04092302的细胞系获得的细胞。
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公开(公告)号：US07048921B2
公开(公告)日：2006-05-23
申请号：US09760274
申请日：2001-01-12
CPC分类号： A61K35/30 , A61K35/12 , C12N5/0623 , C12N2500/25 , C12N2500/90 , C12N2501/115 , C12N2501/24 , C12N2501/392 , C12N2501/395 , C12N2501/91
摘要： The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are encompassed by the invention.
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