公开(公告)号：US07056910B2

公开(公告)日：2006-06-06

申请号：US10432732

申请日：2001-11-27

申请人： Hiroyuki Koshio ,  Akio Kakefuda ,  Ippei Sato ,  Ryutaro Wakayama ,  Masanao Sanagi

发明人： Hiroyuki Koshio ,  Akio Kakefuda ,  Ippei Sato ,  Ryutaro Wakayama ,  Masanao Sanagi

IPC分类号： A61P9/00 ,  A61K31/55 ,  A07D487/00

CPC分类号： C07D487/04

摘要： To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供具有优异精氨酸加压素拮抗作用的化合物。 一种新的1,4,5,6-四氢咪唑并[4,5-d]苯并吖庚因衍生物或其药学上可接受的盐。

公开(公告)号：US20050096322A1

公开(公告)日：2005-05-05

申请号：US10505939

申请日：2003-02-27

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

公开(公告)号：US20130029973A1

公开(公告)日：2013-01-31

申请号：US13639260

申请日：2011-04-27

申请人： Shunichiro Hachiya ,  Masanori Miura ,  Yoshimasa Imamura ,  Daisuke Kaga ,  Ippei Sato ,  Hiroyuki Moritomo ,  Koji Kato ,  Kazuhiro Terai ,  Yoh Terada

发明人： Shunichiro Hachiya ,  Masanori Miura ,  Yoshimasa Imamura ,  Daisuke Kaga ,  Ippei Sato ,  Hiroyuki Moritomo ,  Koji Kato ,  Kazuhiro Terai ,  Yoh Terada

IPC分类号： A61K31/381 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4535 ,  A61K31/444 ,  A61P7/00 ,  C07D409/12 ,  C07D413/14 ,  C07D413/12 ,  C07D409/14 ,  C07D333/66 ,  A61K31/55 ,  A61K31/4025

CPC分类号： C07D333/66 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/63 ,  A61K31/7042 ,  C07D333/68 ,  C07D409/12

摘要： A compound has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating hyperphosphatemia, preventing hyperphosphatemia, or both. The compound is a tetrahydrobenzothiophene compound. A pharmaceutical composition for treating hyperphosphatemia includes the compound or salt thereof. A method of treating hyperphosphatemia includes administering to a subject an effective amount of the compound or salt thereof.

摘要翻译： 化合物具有肠道磷酸盐转运蛋白（NPT-IIb）抑制作用，可用作治疗高磷血症，预防高磷酸血症或二者的活性成分。 该化合物是四氢苯并噻吩化合物。 用于治疗高磷血症的药物组合物包括其化合物或其盐。 治疗高磷血症的方法包括给予受试者有效量的化合物或其盐。

公开(公告)号：US20070265289A1

公开(公告)日：2007-11-15

申请号：US11578608

申请日：2005-04-13

申请人： Yoshinori Okamoto ,  Hirokazu Kubota ,  Ippei Sato ,  Kazuyuki Hattori ,  Takatoshi Kanayama ,  Kazuhiro Yokoyama ,  Yoshiya Terai ,  Masahiro Takeuchi

发明人： Yoshinori Okamoto ,  Hirokazu Kubota ,  Ippei Sato ,  Kazuyuki Hattori ,  Takatoshi Kanayama ,  Kazuhiro Yokoyama ,  Yoshiya Terai ,  Masahiro Takeuchi

IPC分类号： A61K31/506 ,  C07D403/02

CPC分类号： C07D401/04 ,  A61K31/506 ,  A61K31/55 ,  C07D401/12 ,  C07D403/04 ,  C07D413/04

摘要： The invention relates to a compound useful as remedies or preventives for IKK2-related inflammatory diseases or autoimmune diseases, or that is, a 2-aminopyrimidine derivative having a 2-hydroxyphenyl group at the 6-position thereof and having a saturated cyclic group that contains one nitrogen atom, such as piperidine, at the 4-position thereof. The pharmaceutical composition of the invention and the compound of the invention have an excellent antiinflammatory effect based on the IKK2-inhibitory effect thereof, and are therefore useful for remedies and preventives for inflammatory diseases and autoimmune diseases, especially for rheumatoid arthritis.

摘要翻译： 本发明涉及可用作IKK2相关炎性疾病或自身免疫性疾病的补救措施或预防药物的化合物，或其6-位上具有2-羟基苯基并具有饱和环状基团的2-氨基嘧啶衍生物，其含有 一个氮原子，例如哌啶，在其4-位。 本发明的药物组合物和本发明化合物基于IKK2抑制作用具有优异的抗炎作用，因此可用于炎性疾病和自身免疫疾病，特别是类风湿性关节炎的治疗和预防药物。

公开(公告)号：US20060142268A1

公开(公告)日：2006-06-29

申请号：US11353995

申请日：2006-02-15

申请人： Hiroyuki Koshio ,  Akio Kakefuda ,  Ippei Sato ,  Ryutaro Wakayama ,  Masanao Sanagi

发明人： Hiroyuki Koshio ,  Akio Kakefuda ,  Ippei Sato ,  Ryutaro Wakayama ,  Masanao Sanagi

IPC分类号： A61K31/55 ,  C07D487/02

CPC分类号： C07D487/04

摘要： To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供具有优异精氨酸加压素拮抗作用的化合物。 一种新的1,4,5,6-四氢咪唑并[4,5-d]苯并吖庚因衍生物或其药学上可接受的盐。

公开(公告)号：US07173033B2

公开(公告)日：2007-02-06

申请号：US11190859

申请日：2005-07-28

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P19/08

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention.Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

公开(公告)号：US20050261297A1

公开(公告)日：2005-11-24

申请号：US11190859

申请日：2005-07-28

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503 ,  A61K31/55

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.