公开(公告)号：US07105563B2

公开(公告)日：2006-09-12

申请号：US10972023

申请日：2004-10-22

Applicant: Damian Arnaiz ,  Judi Bryant ,  Yuo-Ling Chou ,  Richard Feldman ,  Paul Hrvatin ,  Imadul Islam ,  Monica Kochanny ,  Wheeseong Lee ,  Mark Polokoff ,  Hongyi Yu ,  Shendong Yuan

Inventor： Damian Arnaiz ,  Judi Bryant ,  Yuo-Ling Chou ,  Richard Feldman ,  Paul Hrvatin ,  Imadul Islam ,  Monica Kochanny ,  Wheeseong Lee ,  Mark Polokoff ,  Hongyi Yu ,  Shendong Yuan

IPC: A61K31/404 ,  C07D209/34

CPC classification number: C07D209/34 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06

Abstract: Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.

Abstract translation: 吲哚啉酮衍生物，例如式（I）的化合物：其中A，m，n，R 1，R 2，R 3， 本文所述的本文所述的R 5和R 6 6可用于治疗通过抑制PDK-1活性而减轻疾病的哺乳动物。

公开(公告)号：US20050038037A1

公开(公告)日：2005-02-17

申请号：US10947579

申请日：2004-09-22

Applicant: Judi Bryant ,  Brad Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael Morrissey ,  Guo Wei ,  Wei Xu ,  Shendong Yuan

Inventor： Judi Bryant ,  Brad Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael Morrissey ,  Guo Wei ,  Wei Xu ,  Shendong Yuan

IPC: C07D295/20 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P7/02 ,  A61P43/00 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D295/205 ,  C07D307/33 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D43/02

CPC classification number: C07D295/205 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

公开(公告)号：US06734182B2

公开(公告)日：2004-05-11

申请号：US10114597

申请日：2002-04-02

Applicant: Imadul Islam ,  Daljit S. Dhanoa ,  John M. Finn ,  Ping Du ,  Charles Gluchowski ,  Yoon T. Jeon

Inventor： Imadul Islam ,  Daljit S. Dhanoa ,  John M. Finn ,  Ping Du ,  Charles Gluchowski ,  Yoon T. Jeon

IPC: A61K3118

CPC classification number: C07D405/12 ,  C07C311/18 ,  C07C311/29 ,  C07C311/39 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/48 ,  C07D211/96 ,  C07D215/06 ,  C07D215/54 ,  C07D217/26 ,  C07D241/44

Abstract: This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such as obesity, anorexia nervosa, bulimia nervosa, and abnormal conditions such as sexual/reproductive disorders, depression, epileptic seizure, hypertension, cerebral hemorrhage, congestive heart failure or sleep disturbances and for the treatment of any disease in which antagonism of a Y5 receptor may be useful.

Abstract translation: 本发明涉及新的芳基磺酰胺和磺酰胺化合物，它们选择性地结合并抑制人Y5受体的活性。 本发明还涉及这些化合物用于治疗哺乳障碍如肥胖症，神经性厌食症，神经性贪食症和异常病症如性/生殖障碍，抑郁症，癫痫发作，高血压，脑出血，充血性心力衰竭或 睡眠障碍和用于治疗任何可能使用Y5受体拮抗作用的疾病。

公开(公告)号：US07176207B2

公开(公告)日：2007-02-13

申请号：US11347768

申请日：2006-02-02

Applicant: Judi A Bryant ,  Brad O Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael M Morrissey ,  Robert Guo-Ping Wei ,  Wei Xu ,  Shendong Yuan

Inventor： Judi A Bryant ,  Brad O Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael M Morrissey ,  Robert Guo-Ping Wei ,  Wei Xu ,  Shendong Yuan

IPC: A61K31/495 ,  A61K31/496 ,  C07D295/192

CPC classification number: C07D295/205 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract translation: 下式（I）的化合物：其中A，a，b，R 1，R 2，R 3，R 3， 4和4本文描述的，可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。

公开(公告)号：US20070015759A1

公开(公告)日：2007-01-18

申请号：US11302537

申请日：2005-12-14

Applicant: Volker Schulze ,  Knut Eis ,  Lars Wortmann ,  Dirk Kosemund ,  Olaf Prien ,  Gerhard Siemeister ,  Holger Hess-Stumpp ,  Uwe Eberspaecher ,  Dominic Brittain ,  Imadul Islam

Inventor： Volker Schulze ,  Knut Eis ,  Lars Wortmann ,  Dirk Kosemund ,  Olaf Prien ,  Gerhard Siemeister ,  Holger Hess-Stumpp ,  Uwe Eberspaecher ,  Dominic Brittain ,  Imadul Islam

IPC: A61K31/53 ,  A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02

CPC classification number: C07D277/14 ,  C07D277/20 ,  C07D417/12 ,  C07D417/14

Abstract: This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.

Abstract translation: 本发明涉及通式（I）的噻唑烷酮及其作为polo like kinase（PLK）抑制剂的制备和用途，用于治疗各种疾病。

公开(公告)号：US20060247213A1

公开(公告)日：2006-11-02

申请号：US10508169

申请日：2003-03-21

Applicant: Brad Buckman ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendong Yuan

Inventor： Brad Buckman ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendong Yuan

IPC: A61K31/66 ,  C07D211/26 ,  C07F9/22 ,  C07F9/28 ,  A61K31/445

CPC classification number: C07F9/655345 ,  C07C323/58 ,  C07C327/34 ,  C07D211/34 ,  C07F9/301 ,  C07F9/302 ,  C07F9/306 ,  C07F9/3211 ,  C07F9/3241 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056 ,  C07F9/4087 ,  C07F9/6524

Abstract: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract translation: 下式（I）的化合物，例如：（1）其中R 1，R 2，R 3和R 3， 本文描述的这些化合物可用作血浆羧肽酶B的抑制剂。本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。

公开(公告)号：US06995156B2

公开(公告)日：2006-02-07

申请号：US10947635

申请日：2004-09-22

Applicant: Judi A. Bryant ,  Brad O. Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael M. Morrissey ,  Guo Ping Wei ,  Wei Xu ,  Shendong Yuan

Inventor： Judi A. Bryant ,  Brad O. Buckman ,  Imadul Islam ,  Raju Mohan ,  Michael M. Morrissey ,  Guo Ping Wei ,  Wei Xu ,  Shendong Yuan

IPC: A61K31/496 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D295/205 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract translation: 下式（I）的化合物：化学式id =“CHEM-US-00001”num =“000

公开(公告)号：US5246955A

公开(公告)日：1993-09-21

申请号：US835620

申请日：1992-02-13

Applicant: Edward B. Skibo ,  Imadul Islam ,  David S. Alberts

Inventor： Edward B. Skibo ,  Imadul Islam ,  David S. Alberts

IPC: A61K31/415 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/415

Abstract: New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases.Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

Abstract translation: 发现新的细胞毒素喹诺酮类，指定的氨基甲酸和亚氨基甲氨喋呤具有对卵巢肿瘤，结肠癌，骨髓瘤和类似肿瘤疾病的显着活性。 公开了使用偶氮霉素和亚氨基氮杂吗啉及其药物活性衍生物的药物制剂和治疗方案。

公开(公告)号：US08008325B2

公开(公告)日：2011-08-30

申请号：US12332619

申请日：2008-12-11

Applicant: Brad O. Buckman ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendong Yuan

Inventor： Brad O. Buckman ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendong Yuan

IPC: A61K31/445 ,  C07D211/00

CPC classification number: C07F9/655345 ,  C07C323/58 ,  C07C327/34 ,  C07D211/34 ,  C07F9/301 ,  C07F9/302 ,  C07F9/306 ,  C07F9/3211 ,  C07F9/3241 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056 ,  C07F9/4087 ,  C07F9/6524

Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract translation: 下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法 用于合成这些化合物也在本文中描述。

公开(公告)号：US20090093520A1

公开(公告)日：2009-04-09

申请号：US12332619

申请日：2008-12-11

Applicant: Brad BUCKMAN ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendon Yuan

Inventor： Brad BUCKMAN ,  Kumar Emayan ,  Imadul Islam ,  Karen May ,  Judi Bryant ,  Raju Mohan ,  Christopher West ,  Shendon Yuan

IPC: A61K31/445 ,  C07D211/60 ,  A61P7/02

CPC classification number: C07F9/655345 ,  C07C323/58 ,  C07C327/34 ,  C07D211/34 ,  C07F9/301 ,  C07F9/302 ,  C07F9/306 ,  C07F9/3211 ,  C07F9/3241 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056 ,  C07F9/4087 ,  C07F9/6524

Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract translation: 下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法 用于合成这些化合物也在本文中描述。