公开(公告)号：US20240109843A1

公开(公告)日：2024-04-04

申请号：US18501244

申请日：2023-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  KING ABDULAZIZ UNIVERSITY ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP) ,  IllExcor Therapeutics, LLC

Inventor： Martin SAFO ,  Yan ZHANG ,  Piyusha Pradeep PAGARE ,  Guoyan XU ,  Mohini GHATGE ,  Jurgen VENITZ ,  Osheiza ABDULMALIK ,  Andrew FLEISCHMAN ,  David LIGHT ,  Moustafa EL-ARABY ,  Abdelsattar OMAR

IPC: C07D213/80 ,  A61K9/00 ,  A61P7/00 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04

CPC classification number: C07D213/80 ,  A61K9/0053 ,  A61P7/00 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).

公开(公告)号：US20240174612A1

公开(公告)日：2024-05-30

申请号：US18386724

申请日：2023-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  IllExcor Therapeutics, LLC ,  KING ABDULAZIZ UNIVERSITY ,  CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)

Inventor： Martin SAFO ,  Yan ZHANG ,  Andrew FLEISCHMAN ,  David LIGHT ,  Moustafa EL-ARABY ,  Abdelsattar OMAR ,  Osheiza ABDULMALIK

IPC: C07D213/30 ,  A61P7/06 ,  C07D239/26

CPC classification number: C07D213/30 ,  A61P7/06 ,  C07D239/26

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).

公开(公告)号：US20250019349A1

公开(公告)日：2025-01-16

申请号：US18767363

申请日：2024-07-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  IllExcor Therapeutics, LLC ,  KING ABDULAZIZ UNIVERSITY ,  CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)

Inventor： Martin SAFO ,  Yan ZHANG ,  Andrew FLEISCHMAN ,  David LIGHT ,  Moustafa EL-ARABY ,  Abdelsattar OMAR ,  Osheiza ABDULMALIK

IPC: C07D213/30 ,  A61P7/06 ,  C07D239/26

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).