公开(公告)号：US20250034133A1

公开(公告)日：2025-01-30

申请号：US18708755

申请日：2022-11-11

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Jianping Wu ,  Luoheng QIN ,  Jinxin LIU ,  Yingtao LIU

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/542 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancers.

公开(公告)号：US20240336611A1

公开(公告)日：2024-10-10

申请号：US18547190

申请日：2022-02-23

Applicant: Insilico Medicine IP Limited

Inventor： Aleksandrs ZAVORONKOVS ,  Aleksandr ALIPER ,  Vladimir ALADINSKIY ,  Andrey KUKHARENKO ,  Luoheng QUIN ,  Xin CHENG

IPC: C07D471/08 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/4995 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10

CPC classification number: C07D471/08 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/4995 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10

Abstract: Provided are TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formulas (A), (A*), (I), (II), (AA), (B), (C), (D), (B*), (C*) and (D*). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.

公开(公告)号：US12071443B2

公开(公告)日：2024-08-27

申请号：US18339362

申请日：2023-06-22

Applicant: Insilico Medicine IP Limited

Inventor： Xiao Ding ,  Liena Qin ,  Feng Ren ,  Jianyu Xu

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

公开(公告)号：US20240152763A1

公开(公告)日：2024-05-09

申请号：US18538870

申请日：2023-12-13

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Aleksandr Aliper ,  Aleksandrs Zavoronkovs ,  Alexander Zhebrak ,  Daniil Polykovskiy ,  Maksim Kuznetsov ,  Yan Ivanenkov ,  Mark Veselov ,  Vladimir Aladinskiy ,  Evgeny Putin ,  Yuriy Volkov ,  Arip Asadulaev

IPC: G06N3/092 ,  G06N3/0455 ,  G06N3/0475 ,  G06N3/084

CPC classification number: G06N3/092 ,  G06N3/0455 ,  G06N3/0475 ,  G06N3/084

Abstract: The proposed model is a Variational Autoencoder having a learnable prior that is parametrized with a Tensor Train (VAE-TTLP). The VAE-TTLP can be used to generate new objects, such as molecules, that have specific properties and that can have specific biological activity (when a molecule). The VAE-TTLP can be trained in a way with the Tensor Train so that the provided data may omit one or more properties of the object, and still result in an object with a desired property.

公开(公告)号：US20240150374A1

公开(公告)日：2024-05-09

申请号：US18507566

申请日：2023-11-13

Applicant: Insilico Medicine IP Limited

Inventor： Xin CHENG ,  Luoheng QIN ,  Feng REN

IPC: C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.

公开(公告)号：US20240092764A1

公开(公告)日：2024-03-21

申请号：US18240293

申请日：2023-08-30

Applicant: Insilico Medicine IP Limited

Inventor： Aleksandr Aliper ,  Vladimir Aladinskiy ,  Aleksandrs Zavoronkovs

IPC: C07D405/04 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048

CPC classification number: C07D405/04 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048

Abstract: A TNIK and/or MAP4K4 kinase inhibitor can include: Formula A, derivative, prodrug, salt, stereoisomer, tautomer polymorph, or solvate thereof, or having chirality at any chiral center,






wherein: ring 1 is an aromatic ring with or without hetero atoms; ring 2 is a hetero aromatic ring; ring 3 includes at least one hetero aromatic ring and optionally at least one cycloaliphatic ring fused with the at least one hetero aromatic ring; ring 4 is an aromatic ring with or without hetero atoms; Y is a bond or a linker; Y1 is a linker; each n is independently 0, 1, or 2; each o is independently 0, 1, 2, 3, 4, or 5; each R1, R6, R11, and R12 is independently a substituent; and RA is a ring structure, straight aliphatics, or branched aliphatics, which can be substituted or unsubstituted, any with or without hetero atoms.

公开(公告)号：US20240002406A1

公开(公告)日：2024-01-04

申请号：US18339362

申请日：2023-06-22

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Liena QIN ,  Feng REN ,  Jianyu XU

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

公开(公告)号：US11780854B2

公开(公告)日：2023-10-10

申请号：US18110261

申请日：2023-02-15

Applicant: Insilico Medicine IP Limited

Inventor： Xiao Ding ,  Liena Qin ,  Feng Ren ,  Jianyu Xu

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

公开(公告)号：US11739078B2

公开(公告)日：2023-08-29

申请号：US16796879

申请日：2020-02-20

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Aleksandr Aliper ,  Vladimir Aladinskiy ,  Aleksandrs Zavoronkovs

IPC: A61K31/4439 ,  A61K31/506 ,  A61K31/4164 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D403/04 ,  C07D413/04 ,  C07D401/14 ,  C07D401/04 ,  C07D471/04 ,  C07D491/048 ,  C07D403/14 ,  C07D417/04

CPC classification number: C07D405/04 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048

Abstract: A method of inhibiting TNIK and/or MAP4K4 kinase can include: contacting the kinase with a compound of Formula A,






wherein: ring 1 is an aromatic ring with or without hetero atoms; ring 2 is a hetero aromatic ring; ring 3 includes at least one hetero aromatic ring and optionally at least one cycloaliphatic ring fused with the at least one hetero aromatic ring; ring 4 is an aromatic ring with or without hetero atoms; Y is a bond or a linker; Y1 is a linker; each n is independently 0, 1, or 2; each o is independently 0, 1, 2, 3, 4, or 5; each R1, R6, R11, and R12 is independently a substituent; and RA is a ring structure, straight aliphatics, or branched aliphatics, which can be substituted or unsubstituted, any with or without hetero atoms.

公开(公告)号：US20230192667A1

公开(公告)日：2023-06-22

申请号：US18110517

申请日：2023-02-16

Applicant: Insilico Medicine IP Limited

Inventor： Xin CHENG ,  Yingtao LIU ,  Luoheng QIN ,  Feng REN ,  Jianping WU

IPC: C07D403/14 ,  C07D403/04 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.