公开(公告)号：US20230303556A1

公开(公告)日：2023-09-28

申请号：US18188278

申请日：2023-03-22

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Paul A. BARSANTI ,  Michael Patrick DILLON ,  Firoz Ali JAIPURI ,  Ying-Zi XU ,  Xin LINGHU ,  Monah ABED

IPC: C07D417/14 ,  A61P35/00

CPC classification number: C07D417/14 ,  A61P35/00

Abstract: Provided herein are compounds of Formula (I):




or a pharmaceutically acceptable salt thereof. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. Additional utilities and advantages are described herein.

公开(公告)号：US20230227409A1

公开(公告)日：2023-07-20

申请号：US18009206

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI

IPC: C07D215/22 ,  C07D215/227 ,  C07D215/36 ,  C07D495/04 ,  C07D215/38 ,  C07D401/04 ,  C07D417/12

CPC classification number: C07D215/22 ,  C07D215/227 ,  C07D215/36 ,  C07D495/04 ,  C07D215/38 ,  C07D401/04 ,  C07D417/12

Abstract: Disclosed herein are certain quinolinone derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20230078112A1

公开(公告)日：2023-03-16

申请号：US17615123

申请日：2020-05-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Paul A. BARSANTI ,  Hilary Plake BECK ,  Melissa FLEURY ,  John E. KNOX ,  Ethan DeNardo MCSPADDEN ,  Brian Thomas JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI ,  Chenbo WANG

IPC: C07D417/14 ,  C07D498/18 ,  C07D417/12

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20220098154A1

公开(公告)日：2022-03-31

申请号：US17426408

申请日：2020-01-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI

IPC: C07D213/85 ,  C07D213/64 ,  C07D213/74 ,  C07C237/04 ,  C07D215/54 ,  C07D221/18 ,  C07D217/26 ,  C07C255/58 ,  C07D239/42 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US10815250B2

公开(公告)日：2020-10-27

申请号：US16268444

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07D498/04 ,  A61P35/00 ,  C07D491/107 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US20240335440A1

公开(公告)日：2024-10-10

申请号：US18715927

申请日：2022-12-05

Applicant: IDEAYA BIOSCIENCES, INC. ,  PFIZER INC.

Inventor： Matthew Anthony MAURER ,  Michael Gabriel O'QUIGLEY ,  Richard ZANG ,  Jaymes HOLLAND ,  Mai Hope LE ,  Sarah Shwu-Kuan JAW-TSAI

IPC: A61K31/497 ,  A61K31/4545 ,  A61P35/00

CPC classification number: A61K31/497 ,  A61K31/4545 ,  A61P35/00

Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and c-MET.

公开(公告)号：US20240327399A1

公开(公告)日：2024-10-03

申请号：US18660829

申请日：2024-05-10

Applicant: GlaxoSmithKline Intellectual Property (No.4) Limited ,  IDEAYA Biosciences, Inc.

Inventor： Janos BOTYANSZKI ,  Kevin Duffy ,  Young Eun Choi ,  Claire L. Neilan ,  Marcus M. Fischer

IPC: C07D417/14 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/675 ,  A61P35/00 ,  C07F9/6558

CPC classification number: C07D417/14 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/675 ,  A61P35/00 ,  C07F9/65583

Abstract: Disclosed herein are compounds of Formula (I):




that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20240287080A1

公开(公告)日：2024-08-29

申请号：US18567687

申请日：2022-06-09

Applicant: IDEAYA Biosciences Inc. ,  GlaxoSmithKline Intellectual Property (No.4) Limited

Inventor： Paul A. BARSANTI ,  Kevin J. DUFFY ,  Brian G. LAWHORN ,  Firoz Ali JAIPURI ,  Daneil Lee SEVERANCE ,  Chenbo WANG ,  Nicholas David ADAMS ,  Janos BOTYANSZKI ,  Michael G. DARCY ,  Terence J. KIESOW ,  John J. MCATEE ,  Cuthbert MARTYR ,  Alexander BUTTRAGO SANTANILLA ,  Xinrong TIAN

IPC: C07D487/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/519 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/519 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I):




that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20240208965A1

公开(公告)日：2024-06-27

申请号：US18009172

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  John E. KNOX

IPC: C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06

CPC classification number: C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06

Abstract: Disclosed herein are certain heteroaryl alkylene substituted 2-oxoquinazoline derivatives of Formula (I): (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US11046691B1

公开(公告)日：2021-06-29

申请号：US17175578

申请日：2021-02-12

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Leah Cleary ,  Melissa Fleury ,  Zhonghua Pei ,  Richard Steel ,  James Sutton ,  John E. Knox ,  Zachary E. R. Newby

IPC: C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D239/95 ,  C07D471/04 ,  C07D405/12 ,  C07D403/12 ,  C07D403/14 ,  C07D487/04 ,  C07D401/14 ,  C07D401/12 ,  C07D413/12 ,  C07D519/00 ,  C07D417/12 ,  C07D239/80

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.