Invention Publication
- Patent Title: THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF
-
Application No.: US18660829Application Date: 2024-05-10
-
Publication No.: US20240327399A1Publication Date: 2024-10-03
- Inventor: Janos BOTYANSZKI , Kevin Duffy , Young Eun Choi , Claire L. Neilan , Marcus M. Fischer
- Applicant: GlaxoSmithKline Intellectual Property (No.4) Limited , IDEAYA Biosciences, Inc.
- Applicant Address: GB CA Stevenage
- Assignee: GlaxoSmithKline Intellectual Property (No.4) Limited,IDEAYA Biosciences, Inc.
- Current Assignee: GlaxoSmithKline Intellectual Property (No.4) Limited,IDEAYA Biosciences, Inc.
- Current Assignee Address: GB CA Stevenage
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/444 ; A61K31/454 ; A61K31/4545 ; A61K31/675 ; A61P35/00 ; C07F9/6558
Abstract:
Disclosed herein are compounds of Formula (I):
that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
Information query
