公开(公告)号：US07960584B2

公开(公告)日：2011-06-14

申请号：US11909144

申请日：2006-03-17

Applicant: Young-Ger Suh ,  Hee-Doo Kim ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Yong-Sil Lee ,  Seol Rin Park ,  Chong Hyon Ryu ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-II Kim ,  Joon Ho Bae

Inventor： Young-Ger Suh ,  Hee-Doo Kim ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Yong-Sil Lee ,  Seol Rin Park ,  Chong Hyon Ryu ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-II Kim ,  Joon Ho Bae

IPC: C07C311/02

CPC classification number: C07C275/24 ,  C07C311/08 ,  C07C311/11 ,  C07C323/62 ,  C07D211/46 ,  C07D295/088 ,  C07D295/155 ,  C07D309/12 ,  C07F7/081

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。

公开(公告)号：US6071898A

公开(公告)日：2000-06-06

申请号：US308875

申请日：1999-05-25

Applicant: Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  Hong Pyo Kim ,  Mi Kyeong Lee ,  Hee Sung Choi ,  Eung Seok Lee ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim ,  Sung Ki Seo ,  Tae Gyu Nam ,  Ducky Han ,  Pil Jong Shim ,  Ju Eun Jung ,  Hee Young Beom

Inventor： Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  Hong Pyo Kim ,  Mi Kyeong Lee ,  Hee Sung Choi ,  Eung Seok Lee ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim ,  Sung Ki Seo ,  Tae Gyu Nam ,  Ducky Han ,  Pil Jong Shim ,  Ju Eun Jung ,  Hee Young Beom

IPC: A61K31/56 ,  A61P1/16 ,  A61P35/00 ,  C07C61/29 ,  C07C61/40 ,  C07C62/30 ,  C07C62/32 ,  C07C69/00 ,  C07C69/757 ,  C07F7/18 ,  C07J69/00 ,  C07J53/00

CPC classification number: C07C69/757 ,  C07C61/29 ,  C07C61/40 ,  C07C62/30 ,  C07J69/00 ,  C07C2103/52 ,  Y10S514/893

Abstract: Asiatic acid derivatives having a modified A-ring, as represented by formula 1 are disclosed. ##STR1## Pharmaceutical compositions and methods of treating cancer and hepatotoxicity utilizing compounds of formula 1 are also disclosed.

Abstract translation: PCT No.PCT / KR97 / 00240 Sec。 371日期1999年5月25日 102（e）日期1999年5月25日PCT 1997年11月27日PCT公布。 第WO98 / 23575号公报 日期：1998年6月4日公开了具有由式1表示的改性A环的亚氨基酸衍生物。 还公开了利用式1化合物治疗癌症和肝毒性的药物组合物和方法。

公开(公告)号：US20090105258A1

公开(公告)日：2009-04-23

申请号：US11909136

申请日：2006-03-15

Applicant: Hee-Doo Kim ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Seol Rin Park ,  Joo Hyun Kim ,  Mi Jung Jang ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-II Kim ,  Byoung Young Woo

Inventor： Hee-Doo Kim ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Seol Rin Park ,  Joo Hyun Kim ,  Mi Jung Jang ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-II Kim ,  Byoung Young Woo

IPC: A61K31/5375 ,  C07C275/24 ,  A61P1/02 ,  A61K31/18 ,  A61K31/165 ,  C07C233/40 ,  C07D295/145

CPC classification number: C07C275/24 ,  C07C311/08 ,  C07C311/11 ,  C07C323/62 ,  C07D211/46 ,  C07D295/088 ,  C07D295/155 ,  C07D309/12 ,  C07F7/081

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。

公开(公告)号：US07067553B2

公开(公告)日：2006-06-27

申请号：US10362079

申请日：2001-08-20

Applicant: Young Ger Suh ,  Uh Taek Oh ,  Hee Doo Kim ,  Jee Woo Lee ,  Hyeung Geun Park ,  Young Ho Park ,  Jung Bum Yi

Inventor： Young Ger Suh ,  Uh Taek Oh ,  Hee Doo Kim ,  Jee Woo Lee ,  Hyeung Geun Park ,  Young Ho Park ,  Jung Bum Yi

IPC: A61K31/165 ,  A61K31/195 ,  C07C21/22

CPC classification number: C07D333/42 ,  C07C311/08 ,  C07C311/47 ,  C07C333/20 ,  C07C335/12 ,  C07C335/14 ,  C07C335/20 ,  C07C335/26 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/323 ,  C07D207/416 ,  C07D207/42 ,  C07D209/08 ,  C07D209/14 ,  C07D213/40 ,  C07D213/61 ,  C07D213/76 ,  C07D217/06 ,  C07D231/14 ,  C07D231/56 ,  C07D233/64 ,  C07D235/14 ,  C07D239/42 ,  C07D241/12 ,  C07D241/24 ,  C07D277/28 ,  C07D295/13 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D311/58 ,  C07D317/58 ,  C07D333/20

Abstract: The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Abstract translation: 本发明涉及硫脲化合物和含有它们的药物组合物，特别涉及作为对抗香草素受体（VR）的拮抗剂的新型硫脲化合物及其药物组合物。 作为与香草素受体，疼痛，急性疼痛，慢性疼痛，神经性疼痛，手术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病变，神经变性，神经性皮肤病，中风，膀胱过度敏感性， 肠易激综合征，哮喘或慢性阻塞性肺疾病等呼吸系统疾病，皮肤，眼睛或粘膜的刺激​​，发炎，胃十二指肠溃疡，炎性肠病和炎症性疾病等。 本发明提供了用于预防或治疗这些疾病的药物组合物。

公开(公告)号：US06476076B1

公开(公告)日：2002-11-05

申请号：US09914000

申请日：2001-08-20

Applicant: Jeewoo Lee ,  Uhtaek Oh ,  Young-Ho Park ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Hee-Doo Kim

Inventor： Jeewoo Lee ,  Uhtaek Oh ,  Young-Ho Park ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Hee-Doo Kim

IPC: A01N4728

CPC classification number: C07C335/12 ,  C07C235/34

Abstract: The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.

Abstract translation: 本发明涉及含有树脂毒素药效学的新型香草酸类似物，包含这些类似物的药物组合物，以及它们作为香草素受体激动剂和强力镇痛药的用途。 本发明提供用于治疗急性，慢性，炎性或神经性疼痛或用于治疗膀胱过敏症的药物组合物。

公开(公告)号：US06274559B1

公开(公告)日：2001-08-14

申请号：US09380100

申请日：1999-08-27

Applicant: Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  Hong Pyo Kim ,  Mi Kyeong Lee ,  Hee Sung Choi ,  Eung Seok Lee ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim

Inventor： Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  Hong Pyo Kim ,  Mi Kyeong Lee ,  Hee Sung Choi ,  Eung Seok Lee ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim

IPC: A61K3100

CPC classification number: A61K31/7024 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/336 ,  A61K31/351 ,  A61K31/357 ,  Y10S514/893 ,  Y10S514/894

Abstract: Compositions and methods of treating or preventing hepatotoxicity utilizing asiatic acid derivatives of Formula 1 are disclosed.

Abstract translation: 公开了使用式1的积雪草酸衍生物治疗或预防肝毒性的组合物和方法。

公开(公告)号：US06169112A

公开(公告)日：2001-01-02

申请号：US09308876

申请日：1999-05-25

Applicant: Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  So Ra Kim ,  Sung Ki Seo ,  Tae Gyu Nam ,  Ducky Han ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim ,  Jae Ho Park ,  Pil Jong Shim ,  Ju Eun Jung ,  Hee Young Beom

Inventor： Sang Sup Jew ,  Hyeung Geun Park ,  Hee Doo Kim ,  Young Hoon Jung ,  Young Choong Kim ,  So Ra Kim ,  Sung Ki Seo ,  Tae Gyu Nam ,  Ducky Han ,  Chi Hyoung Yoo ,  Doo Yeon Lim ,  Jeong Hoon Kim ,  Hee Man Kim ,  Jae Ho Park ,  Pil Jong Shim ,  Ju Eun Jung ,  Hee Young Beom

IPC: A01N3700

CPC classification number: A61K31/19 ,  A61K31/215

Abstract: Disclosed is the use of 2-oxoasiatic acid in the treatment of dementia or cognitive disorders.

Abstract translation: 公开了2-氧基碳酸在治疗痴呆或认知障碍中的用途

公开(公告)号：US07858621B2

公开(公告)日：2010-12-28

申请号：US11829531

申请日：2007-07-27

Applicant: Sun-Young Kim ,  Jin Kwan Kim ,  Ki-Wha Lee ,  Byoung Young Woo ,  Song Seok Shin ,  Joo-Hyun Moh ,  Sung-Il Kim ,  Yeon Su Jeong ,  Kyung Min Lim ,  Jin Kyu Choi ,  Jun Yong Ha ,  Hyun-Ju Koh ,  Young-Ho Park ,  Young-Ger Suh ,  Hee-Doo Kim ,  Hyeung-Geun Park ,  Uh Taek Oh

Inventor： Sun-Young Kim ,  Jin Kwan Kim ,  Ki-Wha Lee ,  Byoung Young Woo ,  Song Seok Shin ,  Joo-Hyun Moh ,  Sung-Il Kim ,  Yeon Su Jeong ,  Kyung Min Lim ,  Jin Kyu Choi ,  Jun Yong Ha ,  Hyun-Ju Koh ,  Young-Ho Park ,  Young-Ger Suh ,  Hee-Doo Kim ,  Hyeung-Geun Park ,  Uh Taek Oh

IPC: C07D401/04 ,  C07D213/56 ,  A61K31/44

CPC classification number: C07D213/74 ,  C07C311/08 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D295/155

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same.The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。

公开(公告)号：US07763657B2

公开(公告)日：2010-07-27

申请号：US11909136

申请日：2006-03-15

Applicant: Hee-Doo Kim ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Seol Rin Park ,  Joo Hyun Kim ,  Mi Jung Jang ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-Il Kim ,  Byoung Young Woo

Inventor： Hee-Doo Kim ,  Young-Ger Suh ,  Hyeung-Geun Park ,  Uh Taek Oh ,  Seol Rin Park ,  Joo Hyun Kim ,  Mi Jung Jang ,  Young-Ho Park ,  Song Seok Shin ,  Sun-Young Kim ,  Jin Kwan Kim ,  Yeon Su Jeong ,  Ki-Wha Lee ,  Jin Kyu Choi ,  Kyung Min Lim ,  Hyun Ju Koh ,  Joo Hyun Moh ,  Sung-Il Kim ,  Byoung Young Woo

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/351 ,  A61K31/4453 ,  A61K31/45 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5375 ,  C07D241/04 ,  C07D265/30 ,  C07D211/06 ,  C07D211/46 ,  C07D315/00 ,  C07C311/08 ,  C07C275/24

CPC classification number: C07C275/24 ,  C07C311/08 ,  C07C311/11 ,  C07C323/62 ,  C07D211/46 ,  C07D295/088 ,  C07D295/155 ,  C07D309/12 ,  C07F7/081

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。

公开(公告)号：US20080312234A1

公开(公告)日：2008-12-18

申请号：US11829531

申请日：2007-07-27

Applicant: Sun-Young KIM ,  Jin Kwan KIM ,  Ki-Wha LEE ,  Byoung Young WOO ,  Song Seok SHIN ,  Joo-Hyun MOH ,  Sung-Il Kim ,  Yeon Su JEONG ,  Kyung Min LIM ,  Jin Kyu CHOI ,  Jun Yong HA ,  Hyun-Ju KOH ,  Young-Ho PARK ,  Young-Ger SUH ,  Hee-Doo KIM ,  Hyeung-Geun PARK ,  Uh Taek OH

Inventor： Sun-Young KIM ,  Jin Kwan KIM ,  Ki-Wha LEE ,  Byoung Young WOO ,  Song Seok SHIN ,  Joo-Hyun MOH ,  Sung-Il Kim ,  Yeon Su JEONG ,  Kyung Min LIM ,  Jin Kyu CHOI ,  Jun Yong HA ,  Hyun-Ju KOH ,  Young-Ho PARK ,  Young-Ger SUH ,  Hee-Doo KIM ,  Hyeung-Geun PARK ,  Uh Taek OH

IPC: A61K31/44 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61P25/00 ,  A61P9/00 ,  C07D213/56 ,  C07D213/63 ,  C07D213/72 ,  C07D401/04 ,  C07D413/04

CPC classification number: C07D213/74 ,  C07C311/08 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D295/155

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。