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    Modeling of blends on bosses and faces of a solid model pocket
    3.
    发明授权
    Modeling of blends on bosses and faces of a solid model pocket 有权

    公开(公告)号：US11361116B2

    公开(公告)日：2022-06-14

    申请号：US15775562

    申请日：2015-11-11

    Applicant: SIEMENS PRODUCT LIFECYCLE MANAGEMENT SOFTWARE INC. ,  Xiuchang Li ,  Hui Qin ,  Feng Yu

    Inventor： Xiuchang Li ,  Hui Qin ,  Feng Yu

    IPC: G06F30/00 ,  G06F30/17 ,  G06F119/18

    Abstract: Methods for accurately modeling blends in a solid model and corresponding systems and computer-readable mediums. A method includes receiving a solid model including a plurality of faces and bosses, and identifying a pocket from the plurality of faces, including one or more pocket edges to be blended. The method includes performing an analyze pockets process on the pocket and identifying at least one of a tool type, a tool method, or a tool dimension for machining the pocket. The method includes performing a blend pocket process to model blends on the pocket edges and adding blends to the solid model at the pocket edges in a predefined order, according to the blend pocket analysis, to produce a modified solid model. The method includes displaying the modified solid model by the data processing system.

    MODELING OF BLENDS ON A SOLID MODEL OF A POCKET
    4.
    发明申请
    MODELING OF BLENDS ON A SOLID MODEL OF A POCKET 审中-公开
    泡沫固体模型的建模

    公开(公告)号：US20160078151A1

    公开(公告)日：2016-03-17

    申请号：US14889481

    申请日：2013-05-24

    Applicant: Yong Feng ZHAO ,  Hui QIN ,  Xiuchang LI ,  James Joseph WOJCIK ,  Derek ENGLAND ,  Feng YU

    Inventor： Yong Feng Zhao ,  Hui Qin ,  Xiuchang Li ,  James Joseph Wojcik ,  Derek England ,  Feng Yu

    IPC: G06F17/50

    CPC classification number: G06F17/50 ,  G05B19/4097 ,  G06F17/5086 ,  G06F2217/12 ,  Y02P90/265

    Abstract: Methods for accurately modeling blends in a solid model and corresponding systems and computer-readable mediums. A method includes receiving a solid model including a plurality of faces and identifying a pocket from the plurality of faces, including one or more pocket edges to be blended. The method includes performing an analyze pockets process on the pocket and identifying at least one of a tool type, a tool method, or a tool dimension for machining the pocket. The method includes performing a blend pocket process to model blends on the pocket edge and adding a blend to the solid model at the pocket edges, according to the blend pocket process, to produce a modified solid model. The method includes displaying the modified solid model by the data processing system.

    Abstract translation: 用于在实体模型和相应的系统和计算机可读介质中精确地建模混合物的方法。 一种方法包括接收包括多个面的实体模型，并从多个面识别口袋，包括要混合的一个或多个口袋边缘。 该方法包括在口袋上执行分析口袋过程，并且识别用于加工口袋的工具类型，工具方法或工具尺寸中的至少一个。 该方法包括执行混合袋工艺以在口袋边缘上模拟混合物，并根据混合口袋工艺在口袋边缘处向固体模型添加混合物以产生改性的固体模型。 该方法包括由数据处理系统显示修改的实体模型。

    Pharmaceutical Combinations
    8.
    发明申请
    Pharmaceutical Combinations 审中-公开
    药物组合

    公开(公告)号：US20160339023A1

    公开(公告)日：2016-11-24

    申请号：US15107232

    申请日：2014-12-19

    Applicant: Fang Li ,  Hui-Qin WANG ,  Ensar HALILOVIC ,  Jinsheng LIANG

    Inventor： Fang Li ,  Hui-Qin WANG ,  Ensar HALILOVIC ,  Jinsheng LIANG

    IPC: A61K31/506 ,  A61K31/496

    CPC classification number: A61K31/506 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/435 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

    Abstract: A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor or a pharmaceutically acceptable salt, or at least one BRaf inhibitor or a pharmaceutically acceptable salt, and optionally a pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of cancer; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

    Abstract translation: 一种药物组合，其包含（a）ALK抑制剂或其药学上可接受的盐，和（b）至少一种HDMA-2 / p53受体抑制剂或其药学上可接受的盐，或至少一种BRaf抑制剂或药学上可接受的盐， 和任选的药学上可接受的载体，用于同时，分别或连续施用; 这种组合在治疗癌症中的用途; 以及治疗患有增殖性疾病的受试者的方法，包括施用治疗有效量的这种组合。

    PHARMACEUTICAL COMPOSITIONS
    9.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20160331751A1

    公开(公告)日：2016-11-17

    申请号：US15106886

    申请日：2014-12-19

    Applicant: Stephane Ferretti ,  Sebastien Jeay ,  Ensar Halilovic ,  Fang Li ,  Hui-Qin Wang

    Inventor： Stephane Ferretti ,  Sebastien Jeay ,  Ensar Halilovic ,  Fang Li ,  Hui-Qin Wang

    IPC: A61K31/519 ,  A61K31/506 ,  A61K31/496

    CPC classification number: A61K31/519 ,  A61K31/4188 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61K2300/00

    Abstract: The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.

    Abstract translation: 本公开涉及mdm2 / 4抑制剂的药物组合，即（S）-1-（4-氯 - 苯基）-7-异丙氧基-6-甲氧基-2-（4- {甲基 - [4-（4 - 甲基-3-氧代 - 哌嗪-1-基） - 反式 - 环己基甲基] - 氨基} - 苯基）-1,4-二氢-2H-异喹啉-3-酮或（S）-5-（5-氯 - -1-甲基-2-氧代-1,2-二氢 - 吡啶-3-基）-6-（4-氯 - 苯基）-2-（2,4-二甲氧基 - 嘧啶-5-基）-1-异丙基 -5,6-二氢-1H-吡咯并[3,4-d]咪唑-4-酮和细胞周期蛋白依赖性激酶4/6（CDK4 / 6）抑制剂7-环戊基-2-（5-哌嗪-1-基） 吡啶-2-基氨基）-7H-吡咯并[2,3-d]嘧啶-6-甲酸二甲基酰胺。 此外，本公开涉及药物组合产品。 本公开还涉及包含所述mdm2 / 4抑制剂或细胞周期蛋白依赖性激酶4/6（CDK4 / 6）抑制剂的相应药物制剂，用途和治疗方法。

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