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公开(公告)号：US20150018301A1
公开(公告)日：2015-01-15
申请号：US13508180
申请日：2010-11-08
IPC分类号： A61K31/553 , A61K31/404 , A61K31/7064 , A61K31/122 , A61K31/416
CPC分类号： A61K31/553 , A61K31/122 , A61K31/403 , A61K31/404 , A61K31/416 , A61K31/519 , A61K31/7064
摘要： Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration were identified. The presently disclosed subject matter establishes that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for treating Parkinson's disease.
摘要翻译： 亮氨酸重复激酶-2（LRRK2）突变是帕金森病的常见病因。 鉴定了在LRRK2诱导的神经变性的体外和体内模型中保护的LRRK2激酶的抑制剂。 目前公开的主题确定LRRK2诱导的体内神经元的变性是激酶依赖性的，并且LRRK2激酶抑制提供了治疗帕金森病的潜在的新的神经保护范例。
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公开(公告)号：US20140019468A1
公开(公告)日：2014-01-16
申请号：US13549890
申请日：2012-07-16
申请人： Howard Federoff , Ophir Frieder , Eric Burger
发明人： Howard Federoff , Ophir Frieder , Eric Burger
IPC分类号： G06F17/30
CPC分类号： G06F19/345 , G06F19/00 , G06F19/3418 , G06N5/04 , G06Q50/01 , G16H10/60 , G16H50/20
摘要： A system for assisting a subject to select a proper form of treatment. The system comprises: a monitoring section that remotely monitors a health status of the subject; an inference section that infers medical information about the subject based on information subject posted on social networks; a subject database that stores subject's information; and a symptom engine that stores symptoms of medical situations. The inference section applies the health status and the medical information against symptoms stored in the symptom engine to determine a proper form of treatment.
摘要翻译： 用于辅助受试者选择适当形式治疗的系统。 该系统包括：监视部分，其远程监视对象的健康状况; 推理部分，根据在社交网络上张贴的信息主题推断关于该主题的医学信息; 存储主题信息的主题数据库; 以及存储医疗情况症状的症状引擎。 推理部分根据症状引擎中存储的症状来应用健康状况和医疗信息，以确定适当的治疗形式。
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公开(公告)号：US20060009406A1
公开(公告)日：2006-01-12
申请号：US10978927
申请日：2004-11-01
CPC分类号： A61K38/47 , A01H5/02 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0306 , A61K48/00 , A61K48/005 , C07K2319/00 , C07K2319/20 , C12N9/00 , C12N9/2402 , C12N15/635 , C12N15/85 , C12N15/8509 , C12N2740/15043 , C12N2740/16043 , C12N2800/30 , C12N2830/002 , C12N2840/203 , C12N2840/206 , C12Y302/01052
摘要： Disclosed are compositions and methods related to nucleic acid constructs containing a HexB encoding element and a HexA encoding element. These constructs can be used in the treatment of Tay-Sachs and Sandoff disease.
摘要翻译： 公开了与含有HexB编码元件和HexA编码元件的核酸构建体相关的组合物和方法。 这些构建体可用于治疗泰沙和沙多夫病。
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公开(公告)号：US20130013332A1
公开(公告)日：2013-01-10
申请号：US13543044
申请日：2012-07-06
申请人： Ophir Frieder , Howard Federoff
发明人： Ophir Frieder , Howard Federoff
IPC分类号： G06Q50/22
摘要： A method and system for tracking patient's response during a clinical trial of a drug, includes publishing an informational item about the clinical trial at a social media platform or a file sharing website; inducing patients to post trial related response at the social media platform or to obtain the informational item from the file sharing website; aggregating patients' responses from the social media platform, download information of the informational item published on the file sharing website, or search queries from search engines; and analyzing aggregated patients' responses, download information, or search queries to obtain knowledge related to the clinical trial.
摘要翻译： 一种用于在药物临床试验期间跟踪患者反应的方法和系统，包括在社交媒体平台或文件共享网站上发布关于临床试验的信息项目; 诱导患者在社交媒体平台上发布试用相关回应，或从文件共享网站获取信息项; 汇总患者对社交媒体平台的响应，下载文件共享网站上发布的信息项目信息，或搜索引擎搜索查询; 并分析汇总的患者的反应，下载信息或搜索查询以获得与临床试验相关的知识。
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5.发明申请DETECTION OF FRAGMENTS OF NECTIN-1 FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE 审中-公开检测NECTIN-1片段对阿尔茨海默病的诊断公开(公告)号：US20100285597A1
公开(公告)日：2010-11-11
申请号：US12601673
申请日：2008-05-27
申请人： Howard Federoff , Seung T. Lim
发明人： Howard Federoff , Seung T. Lim
IPC分类号： G01N33/68 , C07H21/04 , C07K14/47 , G01N33/559
CPC分类号： G01N33/6896 , G01N2333/70503 , G01N2333/96425 , G01N2800/2821
摘要： Methods for diagnosing Alzheimer's Disease by detection of fragments of nectin-1 are described. Nectin-1 is shown to be a substrate for proteases associated with the onset of Alzheimer's Disease, including α-secretase, γ-secretase and BACE1 or a BACE1-like protease. The fragments produced by the action of these and other proteases on Nectin-1 can be used to diagnosis Alzheimer's Disease or a predilection towards Alzheimer's Disease.
摘要翻译： 描述了通过检测Nectin-1片段来诊断阿尔茨海默氏病的方法。 Nectin-1显示为与阿尔茨海默氏病发病相关的蛋白酶的底物，包括α-分泌酶，γ-分泌酶和BACE1或BACE1样蛋白酶。 通过这些和其他蛋白酶对Nectin-1的作用产生的片段可用于诊断阿尔茨海默病或偏爱阿尔茨海默氏病。
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公开(公告)号：US20060171922A1
公开(公告)日：2006-08-03
申请号：US10516211
申请日：2003-05-30
申请人： Howard Federoff , William Bowers
发明人： Howard Federoff , William Bowers
IPC分类号： A61K48/00 , C12N15/869
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16623 , C12N2710/16643 , C12N2740/16234 , C12N2800/40 , C12N2800/90
摘要： The invention features new helper virus-free methods for making herpes virus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patient's cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.
摘要翻译： 本发明具有用于制备可用于免疫治疗的疱疹病毒扩增子颗粒的新的无辅助病毒的方法，包括用于治疗任何数量的感染性疾病和癌症（包括慢性淋巴细胞性白血病，血细胞变为恶性的其它癌症，淋巴瘤（ 本文描述了制备无辅助病毒的HSV扩增子颗粒的方法;含有这些颗粒的细胞（例如，包装细胞系或患者细胞，体内或离体感染）;产生的颗粒（例如霍奇金淋巴瘤或非霍奇金淋巴瘤） 根据这些方法;以及根据这些方法制备的具有hf-HSV颗粒的患者的治疗方法。
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公开(公告)号：US10902955B1
公开(公告)日：2021-01-26
申请号：US16878433
申请日：2020-05-19
发明人： Howard Federoff , Ophir Frieder
摘要： A triage system that determines whether a user is likely to have contracted a disease based on sensor data received from a user device (e.g., a smartphone or activity tracker). Each symptom is identified by comparing sensor data to a predetermined baseline and comparing the difference to a predetermined symptom threshold. Because direct measurement of symptoms using the sensors available to the user may not be feasible or sufficiently accurate, the triage system also uses surrogates the identify certain symptoms. For example, a fever may be identified using heart data, a cough or shortness of breath may be identified by analyzing recorded sound, fatigue may be identified by analyzing the movement of the user device, and loss of smell or taste may be identified by recording sound and using speech detection algorithms to identify phrases in the recorded sound indicative of loss of smell or taste.
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公开(公告)号：US09305140B2
公开(公告)日：2016-04-05
申请号：US13549890
申请日：2012-07-16
申请人： Howard Federoff , Ophir Frieder , Eric Burger
发明人： Howard Federoff , Ophir Frieder , Eric Burger
CPC分类号： G06F19/345 , G06F19/00 , G06F19/3418 , G06N5/04 , G06Q50/01 , G16H10/60 , G16H50/20
摘要： A system for assisting a subject to select a proper form of treatment. The system comprises: a monitoring section that remotely monitors a health status of the subject; an inference section that infers medical information about the subject based on information subject posted on social networks; a subject database that stores subject's information; and a symptom engine that stores symptoms of medical situations. The inference section applies the health status and the medical information against symptoms stored in the symptom engine to determine a proper form of treatment.
摘要翻译： 用于辅助受试者选择适当形式治疗的系统。 该系统包括：监视部分，其远程监视对象的健康状况; 推理部分，根据在社交网络上张贴的信息主题推断关于该主题的医学信息; 存储主题信息的主题数据库; 以及存储医疗情况症状的症状引擎。 推理部分根据症状引擎中存储的症状来应用健康状况和医疗信息，以确定适当的治疗形式。
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公开(公告)号：US6051428A
公开(公告)日：2000-04-18
申请号：US45476
申请日：1998-01-20
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C12N5/10 , C12N15/12 , C12N15/869 , C12N15/63 , A61K39/245 , C12N15/38
CPC分类号： C12N15/86 , A61K39/0011 , A61K2039/5156 , A61K2039/55516 , A61K48/00 , C12N2710/16643 , C12N2830/00 , C12N2830/60 , C12N2840/203
摘要： An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES; intercellular adhesion molecules, for example ICAM-1 and costimulatory factors such as B7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins.
摘要翻译： 通过用包含免疫调节蛋白的基因的单纯疱疹病毒扩增子转导肿瘤细胞来产生肿瘤细胞的自体疫苗，以提供细胞的免疫调节蛋白的瞬时表达。 肿瘤细胞可以离体或体内用单纯疱疹病毒扩增子转导。 合适的免疫调节蛋白包括细胞因子，例如白介素，干扰素和趋化因子，例如RANTES; 细胞间粘附分子，例如ICAM-1和共刺激因子如B7.1。 肿瘤细胞还可以用含有两种或多种不同免疫调节蛋白的含有一个或多个含扩增子的基因转导。
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公开(公告)号：US20070264280A1
公开(公告)日：2007-11-15
申请号：US10578561
申请日：2004-11-08
申请人： Howard Federoff , William Bowers
发明人： Howard Federoff , William Bowers
CPC分类号： A61K48/005 , A61K39/0007 , A61K47/646 , A61K2039/6037 , C12N2799/028
摘要： The invention includes therapeutic compositions and methods useful in the treatment of neurodegenerative diseases, such as those characterized by accumulation of extracellular plaques. Such neurodegenerative diseases include Alzheimer's disease. The compositions of the invention include HSVAβ/TtxFC, which can be used to deliver effective therapeutic benefits to a patient without inducing inflammation.
摘要翻译： 本发明包括可用于治疗神经变性疾病的治疗组合物和方法，例如以细胞外斑块积聚为特征的那些。 这样的神经变性疾病包括阿尔茨海默氏病。 本发明的组合物包括HSVAbeta / TtxFC，其可用于在不诱发炎症的情况下向患者递送有效的治疗益处。
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