公开(公告)号：US20120304852A1

公开(公告)日：2012-12-06

申请号：US13579603

申请日：2011-03-02

Applicant: Hiroshi Yamagata ,  Hidetaka Shima

Inventor： Hiroshi Yamagata ,  Hidetaka Shima

IPC: F02F1/00 ,  B22D27/02 ,  B22D25/06

CPC classification number: B22D19/0009 ,  B22D15/02 ,  B22D19/08 ,  B22D29/00 ,  C23C4/134 ,  F02F1/004 ,  F02F1/102 ,  F02F2200/00 ,  F16J10/04

Abstract: Disclosed is a cylinder liner having a high bonding strength to a cylinder block. Further disclosed is a method for producing the same. The cylinder liner uses a silicon-aluminum alloy as a material; a plurality of protrusions are formed on the external surface thereof; and the protrusions each contain a pillar section extending from the external surface, and a head section formed at the end of the pillar section.

Abstract translation: 公开了一种对气缸体具有高粘合强度的气缸套。 进一步公开的是其制造方法。 气缸套采用硅铝合金作为材料; 在其外表面上形成多个突起; 并且所述突起各自包含从所述外表面延伸的柱部，以及形成在所述柱部的端部的头部。

公开(公告)号：US20100099909A1

公开(公告)日：2010-04-22

申请号：US12563366

申请日：2009-09-21

Applicant: Shigeyoshi NISHINO ,  Hidetaka SHIMA ,  Hiroyuki ODA ,  Yoji OMATA

Inventor： Shigeyoshi NISHINO ,  Hidetaka SHIMA ,  Hiroyuki ODA ,  Yoji OMATA

IPC: C07C69/76 ,  C07C381/00 ,  C07C67/00

CPC classification number: C07C381/00 ,  C07C2601/12

Abstract: A polycyclic pentafluorosulfanylbenzene compound represented by the following general formula (1) and a process for producing the polycyclic pentafluorosulfanylbenzene compound which comprises reacting a specific pentafluorosulfanylbenzene compound with a specific boronic acid compound are provided. The polycyclic pentafluorosulfanylbenzene compound is a novel compound and can be produced by the process industrially advantageously. (R1 to R4 each independently represent hydrogen atom or fluorine atom, R5 represents a hydrocarbon group having at least two cyclic structures which may have substituents, and Z represents keto group, thioketo group, methylene group or difluoromethylene group.)

Abstract translation: 提供由以下通式（1）表示的多环五氟硫烷基苯化合物和制备多环五氟硫烷基苯化合物的方法，其包括使特定的五氟硫烷基苯化合物与特定的硼酸化合物反应。 多环五氟硫烷基苯化合物是新型化合物，可以通过工业上有利的方法制备。 （R 1〜R 4各自独立地表示氢原子或氟原子，R 5表示具有至少两个可具有取代基的环状结构的烃基，Z表示酮基，硫代酮基，亚甲基或二氟亚甲基。

公开(公告)号：US07619084B2

公开(公告)日：2009-11-17

申请号：US11666510

申请日：2005-10-28

Applicant: Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada

Inventor： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada

IPC: C07D239/02

CPC classification number: C07D239/42

Abstract: The present invention is to provide a process for preparing a 4-aminopyrimidine compound represented by the formula (3): wherein R1 and R2 each represent a hydrogen atom or group which does not participate in the reaction and which may have a substituent(s), and R1 and R2 may be bonded to each other to form a ring, and R4 represents a hydrogen atom or a hydrocarbon group, which comprises reacting ammonia, a 3-substituted or unsubstituted acrylonitrile compound represented by the formula (1): CR1(CN)═CR2Y  (1) wherein R1 and R2 have the same meanings as defined above, and Y represents an amino group or OR, where R represents a hydrogen atom or a hydrocarbon group, and an organic acid compound represented by the formula (2): (R3O)3CR4  (2) wherein R3 represents a hydrocarbon group, and R4 has the same meaning as defined above.

Abstract translation: 本发明提供一种制备式（3）表示的4-氨基嘧啶化合物的方法：其中R1和R2各自表示氢原子或不参与反应的基团，并且可以具有取代基， R 1和R 2可以彼此键合形成环，R 4表示氢原子或烃基，其包括使氨，3-取代或未取代的由式（1）表示的丙烯腈化合物：CR1（ CN）-CR2Y（1）其中R1和R2具有与上述相同的含义，Y表示氨基或OR，其中R表示氢原子或烃基，和由式（2）表示的有机酸化合物 ）：（R3O）3CR4（2）其中R3表示烃基，R4具有与上述相同的含义。

公开(公告)号：US20090171083A1

公开(公告)日：2009-07-02

申请号：US12400895

申请日：2009-03-10

Applicant: Shigeyoshi NISHINO ,  Kenji HIROTSU ,  Hidetaka SHIMA ,  Takashi HARADA ,  Hiroyuki ODA

Inventor： Shigeyoshi NISHINO ,  Kenji HIROTSU ,  Hidetaka SHIMA ,  Takashi HARADA ,  Hiroyuki ODA

IPC: C07D239/94

CPC classification number: C07D239/88 ,  C07D239/94

Abstract: A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.

Abstract translation: 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由 在第二有机溶剂的存在下，式R5-NH-R6（R5和R6各自表示氢或任选取代的烃基）。

公开(公告)号：US20080045712A1

公开(公告)日：2008-02-21

申请号：US11666510

申请日：2005-10-28

Applicant: Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada

Inventor： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada

IPC: C07D239/42

CPC classification number: C07D239/42

Abstract: The present invention is to provide a process for preparing a 4-aminopyrimidine compound represented by the formula (3): wherein R1 and R2 each represent a hydrogen atom or group which does not participate in the reaction and which may have a substituent(s), and R1 and R2 may be bonded to each other to form a ring, and R4 represents a hydrogen atom or a hydrocarbon group, which comprises reacting ammonia, a 3-substituted or unsubstituted acrylonitrile compound represented by the formula (1): CR1(CN)═CR2Y  (1) wherein R1 and R2 have the same meanings as defined above, and Y represents an amino group or OR, where R represents a hydrogen atom or a hydrocarbon group, and an organic acid compound represented by the formula (2): (R3O)3CR4  (2) wherein R3 represents a hydrocarbon group, and R4 has the same meaning as defined above.

Abstract translation: 本发明提供一种制备由式（3）表示的4-氨基嘧啶化合物的方法：其中R 1和R 2各自表示氢原子或基团 其不参与反应并且可以具有取代基，R 1和R 2可以彼此键合形成环，并且R 其包括使氨，式（1）表示的3-取代或未取代的丙烯腈化合物：<？in-line-formula description =“In- 线公式“end =”lead“？> CR <1>（CN）-CR 2 Y（1）<？in-line-formula description =”在线公式 “其中R 1和R 2”具有与上述相同的含义，Y表示氨基或OR，其中R表示氢 原子或烃基，以及由式（2）表示的有机酸化合物：<？in-line-formula description =“In-line Form （“O”）3“（4）”（2）<？in-line-formula description = 其中R 3表示烃基，并且R 4具有与上述相同的含义，“直链式”末端=“尾”→其中R 3表示烃基。

公开(公告)号：US20050222439A1

公开(公告)日：2005-10-06

申请号：US10516756

申请日：2003-06-10

Applicant: Shigetoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

Inventor： Shigetoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

IPC: C07D309/12 ,  C07D39/06

CPC classification number: C07D309/12

Abstract: The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.

Abstract translation: 本发明涉及一种制备四氢吡喃-4-醇的方法，其包括以下步骤：（A）由式（1）表示的四氢吡喃基-4-甲酸盐的制备步骤：通过3-丁烯-1-醇， 甲醛化合物和甲酸，和（B）然后，使四氢吡喃-4-甲酸酯溶剂化得到由式（2）表示的四氢吡喃-4-醇的溶剂解步骤：和中间体和制备方法 相同。

公开(公告)号：US06541636B2

公开(公告)日：2003-04-01

申请号：US10181973

申请日：2002-07-24

Applicant: Katsumasa Harada ,  Shigeyoshi Nishino ,  Naoko Okada ,  Hidetaka Shima ,  Takashi Harada

Inventor： Katsumasa Harada ,  Shigeyoshi Nishino ,  Naoko Okada ,  Hidetaka Shima ,  Takashi Harada

IPC: C07D21504

CPC classification number: C07D215/12

Abstract: 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is prepared by reacting 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-prop-2-enenitrile is directly formed.

Abstract translation: 3- [2-环丙基-4-（4-氟苯基）-3-喹啉基]丙-2-烯腈是通过2-环丙基-4-（4-氟苯基）喹啉-3-甲醛与乙腈在 然后向反应混合物中加入脱水剂进行脱水。 在常规条件下，在上述反应中形成新的3- [2-环丙基-4-（4-氟 - 苯基） - 喹啉-3-基] -3-羟基丙腈作为中间体。 顺便提及，当上述反应在有机溶剂中进行时，直接形成3- [2-环丙基-4-（4-氟苯基）-3-喹啉基] - 丙-2-烯腈。

公开(公告)号：US08133999B2

公开(公告)日：2012-03-13

申请号：US12484632

申请日：2009-06-15

Applicant: Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Hiroyuki Oda ,  Shinobu Suzuki

Inventor： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Hiroyuki Oda ,  Shinobu Suzuki

IPC: C07D239/72

CPC classification number: C07D239/88 ,  C07C67/31 ,  C07C69/92

Abstract: 6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:

Abstract translation: 可用于合成抗癌药物的式（5）的6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮可以通过2-氨基-4,5-双（2-甲氧基乙氧基 ）苯甲酸酯与原甲酸在乙酸铵存在下反应：

公开(公告)号：US20100010233A1

公开(公告)日：2010-01-14

申请号：US12373548

申请日：2007-07-13

Applicant: Shigeyoshi Nishino ,  Hidetaka Shima ,  Tetsuro Shimano ,  Kimihiko Yoshimura

Inventor： Shigeyoshi Nishino ,  Hidetaka Shima ,  Tetsuro Shimano ,  Kimihiko Yoshimura

IPC: C07D233/40

CPC classification number: C07D233/74

Abstract: An object of the present invention is to provide an industrially suitable process for preparing an imidazolidin-2,4-dione compound which is safe, simple and easy to prepare the imidazolidin-2,4-dione compound with high yield, which is a useful compound, for example, as a material for decomposing a harmful halogenated aromatic hydrocarbon compound such as dioxin, etc., an electroless silver plating solution for electronic parts, or a diazo copying material, etc. This object can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises subjecting a 4,5-dihydroxy-2-imidazolidinone compound, (1) to dehydration reaction in the presence of an acid catalyst(s); or (2) to reaction at 100 to 300° C. Or, it can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises reacting a mixed solution of a urea compound, glyoxal, and a base at 20 to 300° C.Also, an object of the present invention is to provide a method for acquiring a 4,5-dihydroxy-2-imidazolidinone from an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone by a simple and easy method. This object can be solved by a process for acquiring a solid state 4,5-dihydroxy-2-imidazolidinone compound which comprises mixing an organic solvent with an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone compound, and subjecting the mixture to azeotropic distillation.

Abstract translation: 本发明的目的是提供一种工业上合适的制备咪唑烷-2,4-二酮化合物的方法，该方法安全，简单并且容易以高产率制备咪唑烷-2,4-二酮化合物，其是有用的 化合物，例如作为用于分解有害的卤化芳族烃化合物如二恶英等的材料，用于电子部件的无电镀银溶液或重氮复制材料等。该目的可以通过制备方法 包括使4,5-二羟基-2-咪唑啉酮化合物（1）在酸催化剂存在下进行脱水反应的咪唑烷-2,4-二酮化合物; 或（2）在100〜300℃下反应，或者可以通过制备咪唑烷-2,4-二酮化合物的方法来解决，该方法包括使脲化合物，乙二醛和碱的混合溶液 另外，本发明的目的在于提供一种通过简单且简单的方法从含有4,5-二羟基-2-咪唑啉酮的水溶液中获得4,5-二羟基-2-咪唑烷酮的方法， 容易的方法。 该目的可以通过获得固体4,5-二羟基-2-咪唑烷酮化合物的方法来解决，该方法包括将有机溶剂与含有4,5-二羟基-2-咪唑烷酮化合物的水溶液混合，并将该混合物 共沸蒸馏。

公开(公告)号：US20070106083A1

公开(公告)日：2007-05-10

申请号：US10564709

申请日：2004-07-14

Applicant: Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada ,  Shinobu Suzuki

Inventor： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada ,  Shinobu Suzuki

IPC: C07D309/14

CPC classification number: C07D309/10 ,  C07D309/14

Abstract: The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.

Abstract translation: 本发明涉及一种由式（2）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐 由式（1）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，以及其制备方法 准备一样