公开(公告)号：US5712263A

公开(公告)日：1998-01-27

申请号：US663929

申请日：1996-06-14

申请人： Chihiro Yokoo ,  Hisaya Wada ,  Hidemichi Mitome ,  Tatsuhiko Sano ,  Katsuo Hatayama ,  Yasuji Yamada

发明人： Chihiro Yokoo ,  Hisaya Wada ,  Hidemichi Mitome ,  Tatsuhiko Sano ,  Katsuo Hatayama ,  Yasuji Yamada

IPC分类号： C07J7/00 ,  C07J9/00 ,  C07J17/00 ,  C07J21/00 ,  A61K31/58

CPC分类号： C07J21/006 ,  C07J17/00 ,  C07J7/002 ,  C07J9/00

摘要： To provide novel steroid derivatives having an antitumor action which can be synthesized efficiently and stereoselectively by means of synthetic organic chemistry. A steroid derivative represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 13 carbon atoms, A is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, X and Y together form an oxo group or an alkylenedioxy group having 2 or 3 carbon atoms, X is a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom or an alkoxy group having 1 to 5 carbon atoms, with the proviso that when X is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom, and when X is an alkoxy group having 1 to 5 carbon atoms, Y is an alkoxy group having 1 to 5 carbon atoms, or a salt thereof.

摘要翻译： 提供具有抗肿瘤作用的新型类固醇衍生物，其可以通过合成有机化学有效地和立体选择性地合成。 由下式表示的类固醇衍生物：其中R是具有1至13个碳原子的烷基，A是羟基或易于水解成羟基的基团，X和Y一起形成氧代基 或具有2或3个碳原子的亚烷基二氧基，X是羟基，具有1至5个碳原子的烷氧基或易于水解成羟基的基团，Y是氢原子或具有1至5个碳原子的烷氧基 原子，条件是当X是羟基或易于水解成羟基的基团时，Y是氢原子，当X是具有1至5个碳原子的烷氧基时，Y是具有1至 5个碳原子，或其盐。