公开(公告)号：US20160016948A1

公开(公告)日：2016-01-21

申请号：US14745159

申请日：2015-06-19

Applicant: Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

Inventor： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC: C07D471/04 ,  A61K45/06 ,  C07D498/10 ,  A61K31/5355 ,  A61K31/541 ,  C07D498/08 ,  A61K31/538 ,  C07D491/107 ,  A61K31/506 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

Abstract: This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

Abstract translation: 本发明涉及作为含有EGFR突变体的T790M抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗癌症的新化合物。