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1.发明授权2-substituted oleanolic acid derivative, method preparing for same, and application thereof 有权2-取代的齐墩果酸衍生物，其制备方法及其应用公开(公告)号：US09156801B2
公开(公告)日：2015-10-13
申请号：US14362017
申请日：2012-11-30
发明人： Rongzhen Xu , Frank Rong , Hongxi Lai , Fuwen Xie
IPC分类号： A61K31/21 , A61K31/44 , A61K31/497 , A61K31/535 , C07C69/74 , C07D211/68 , C07D265/30 , C07D241/04 , C07D487/00 , C07D295/13 , C07J63/00 , C07C235/84 , C07D213/40
CPC分类号： C07D295/13 , C07C235/84 , C07D213/40 , C07J63/00 , C07J63/008
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-substituted oleanolic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型2-取代齐墩果酸衍生物或其药学上可接受的盐，涉及制备这些化合物的方法，含有这些化合物的组合物 化合物及其在制备抗肿瘤药物中的应用。
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公开(公告)号：US20150238488A1
公开(公告)日：2015-08-27
申请号：US14432389
申请日：2013-09-27
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie
IPC分类号： A61K31/506 , A61K31/4725
CPC分类号： A61K31/506 , A61K31/4725 , A61K31/4745 , A61K2300/00
摘要： The present invention belongs to the field of medicine and pharmaceutical chemistry, specifically relates to novel antitumor pharmaceutical combinations, and particularly relates to pharmaceutical combinations of bisbenzylisoquinoline alkaloids (e.g. berbamine and tetrandrine) and imatinib mesylates and their use in treating tumors.
摘要翻译： 本发明属于医药和药物化学领域，具体涉及新的抗肿瘤药物组合，特别涉及双苄基异喹啉生物碱（例如berbamine和tetrandrine）和甲磺酸伊马替尼的药物组合及其在治疗肿瘤中的用途。
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3.发明授权公开(公告)号：US09771343B2
公开(公告)日：2017-09-26
申请号：US14361533
申请日：2012-11-30
发明人： Frank Rong , Rongzhen Xu , Fuwen Xie , Hongxi Lai
IPC分类号： C07D307/87 , C07J75/00 , C07J73/00 , A61K31/56 , C07D307/77
CPC分类号： C07D307/87 , A61K31/56 , C07D307/77 , C07J73/003 , C07J75/00
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-alkyl- or 2-aromatic-substituted tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When Z=R, said derivative is 2-alkyl-substituted tanshinone I; when Z=Ar, said derivative is 2-aryl-substituted tanshinone I; when Z=Het, said derivative is 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I.
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公开(公告)号：US20150290232A1
公开(公告)日：2015-10-15
申请号：US14432421
申请日：2013-09-27
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie
IPC分类号： A61K31/7048 , A61K31/4745
CPC分类号： A61K31/7048 , A61K31/4745 , A61K31/704 , A61K2300/00
摘要： The present invention belongs to the field of medicine and pharmaceutical chemistry, specifically relates to novel antitumor pharmaceutical combination, and particularly relates to pharmaceutical combination of bisbenzylisoquinoline alkaloids (e.g. berbamine and tetrandrine) and anthracene compounds (e.g. aclarubicin A) and their use in treating tumors.
摘要翻译： 本发明属于医药和药物化学领域，具体涉及新型抗肿瘤药物组合，特别涉及双苄基异喹啉生物碱（例如berbamine和tetrandrine）和蒽化合物（例如阿柔比星A）的药物组合及其在治疗肿瘤中的用途 。
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5.发明申请ACYLATION DERIVATIVES OF PARIDIS SAPONINS I, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 有权PARIDIS芸香苷I的酰化衍生物，其制备方法及其应用公开(公告)号：US20150152133A1
公开(公告)日：2015-06-04
申请号：US14407622
申请日：2013-06-13
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie
IPC分类号： C07J71/00
CPC分类号： C07J71/0005 , A61K31/7048 , C07J71/00
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel Polyphyllin I derivatives of formula (I) that is acylated at the 5′-position of arabinofuranosyl or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
摘要翻译： 本发明属于天然药物和药物化学领域，涉及在阿拉伯呋喃糖基或其药学上可接受的盐的5'-位上被酰化的式（I）的新颖的多烯雌酮I衍生物与制备方法 的这些化合物，含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。
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6.发明授权公开(公告)号：US09902736B2
公开(公告)日：2018-02-27
申请号：US14373556
申请日：2013-01-21
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie , Hongxi Lai
IPC分类号： C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylated-14-acylated oridonin derivative of a general formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and application thereof in preparation of antitumor drugs.
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7.发明授权7-substituted Hanfangichin B derivative, and preparation method and use thereof 有权7-取代的Hanfangichin B衍生物及其制备方法和用途公开(公告)号：US09328122B2
公开(公告)日：2016-05-03
申请号：US14373526
申请日：2013-01-21
发明人： Frank Rong , Rongzhen Xu , Hongxi Lai , Fuwen Xie
IPC分类号： C07D498/18 , C07D491/18
CPC分类号： C07D491/18
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 7-substituted fangchinoline derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.
摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型7-取代的chin啉衍生物及其药学上可接受的加合物，其络合物和盐，用于制备这些化合物的方法，药物 含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。
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8.发明申请1-OXO/ACYLATION-14-ACYLATED ORIDONIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 有权1-OXO / ACYLATION-14-ACYLATED ORIDONIN DORIVATIVE，其制备方法及其应用公开(公告)号：US20140364490A1
公开(公告)日：2014-12-11
申请号：US14373556
申请日：2013-01-21
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie , Hongxi Lai
IPC分类号： C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylated-14-acylated oridonin derivative of a general formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and application thereof in preparation of antitumor drugs.
摘要翻译： 本发明涉及天然药物和药物化学领域，更具体地涉及通式（I）的1-氧代/酰化-14-酰化的牡丹苷衍生物或其药学上可接受的盐，该化合物的制备方法 包含该化合物的药物组合物及其在制备抗肿瘤药物中的应用。
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9.发明授权Acylation derivatives of paridis saponins I, preparation method therefor and application thereof 有权paridis皂苷I的酰化衍生物，其制备方法及其应用公开(公告)号：US09353146B2
公开(公告)日：2016-05-31
申请号：US14407622
申请日：2013-06-13
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie
IPC分类号： C07J21/00 , C07J71/00 , A61K31/7048
CPC分类号： C07J71/0005 , A61K31/7048 , C07J71/00
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel Polyphyllin I derivatives of formula (I) that is acylated at the 5′-position of arabinofuranosyl or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
摘要翻译： 本发明属于天然药物和药物化学领域，涉及在阿拉伯呋喃糖基或其药学上可接受的盐的5'-位上被酰化的式（I）的新颖的多烯雌酮I衍生物与制备方法 的这些化合物，含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。
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10.发明授权2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof 有权2-氨基亚甲基或2-酯化亚甲基丹参酮衍生物及其制备方法和应用公开(公告)号：US09328083B2
公开(公告)日：2016-05-03
申请号：US14361548
申请日：2012-11-30
发明人： Rongzhen Xu , Frank Rong , Fuwen Xie , Hongxi Lai
IPC分类号： C07D307/77 , C07D405/12
CPC分类号： C07D307/77 , C07D405/12
摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When X is nitrogen, formula I indicates 2-aminated methylene tanshinone I; when X is oxygen, formula I indicates 2-esterified methylene tanshinone I.
摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型2-氨基亚甲基或2-酯化亚甲基丹参酮I衍生物或其药学上可接受的盐，用于制备 这些化合物，含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。 当X是氮时，式I表示2-胺化亚甲基丹参酮I; 当X是氧时，式I表示2-酯化的亚甲基丹参酮I.
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