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公开(公告)号：US20160334312A1
公开(公告)日：2016-11-17
申请号：US15222590
申请日：2016-07-28
申请人： Angelo Gaitas , Gwangseong Kim
发明人： Angelo Gaitas , Gwangseong Kim
CPC分类号： G01N1/405 , A61M1/362 , A61M1/3679 , A61M1/3683 , A61M1/3686 , A61M1/3689 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0631 , B01L2300/0877
摘要： The present invention relates to concentrating disease causing agents, such as foodborne pathogens, from complex media to expedite their detection. In particular, the present invention relates to a method to pre-concentrate pathogens rapidly, thereby enabling earlier detection times. Primarily, the present invention utilizes an approach that can concentrate the pathogens by flowing a sample through immuno-capturing tubes (“entrapment chamber” or “chamber”) during an early pre-enrichment period. Also, the invention relates to using binding materials to trap disease causing agent that is desired to be removed from the complex media such as the blood of a patient. It also related to using lights of specific wavelength to inactivate pathogens. The light is used to activate reactive oxygen species using a photo-sensitizer or directly kill the pathogen using light of wavelength between 100 nm and 450 nm.
摘要翻译： 本发明涉及从复杂培养基中浓缩致病因素，如食源性病原体，以加速其检测。 特别地，本发明涉及一种快速预浓缩病原体的方法，从而能够实现较早的检测时间。 主要地，本发明利用了一种方法，该方法可以在早期预富集期间通过使样品通过免疫捕获管（“包埋室”或“室”）来浓缩病原体。 此外，本发明还涉及使用结合材料来捕集期望从诸如患者血液的复合介质中除去的疾病引发剂。 它还涉及使用特定波长的光灭活病原体。 光用于使用光敏剂活化活性氧物质，或者使用100nm至450nm波长的光直接杀死病原体。
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公开(公告)号：US20160058937A1
公开(公告)日：2016-03-03
申请号：US14936112
申请日：2015-11-09
申请人： Angelo Gaitas , Gwangseong Kim
发明人： Angelo Gaitas , Gwangseong Kim
IPC分类号： A61M1/36
CPC分类号： A61M1/3683 , A61M1/362 , A61M1/3679 , A61M1/3686 , A61M1/3689
摘要： The present invention relates to removing disease causing agent such as pathogens from the blood of a patient. Specifically, the invention relates to using coating materials to trap disease causing agent that is desired to be removed from the blood of a patient. It also related to using lights of specific wavelength to inactivate pathogens. The light is used to activate reactive oxygen species using a photo-sensitizer or directly kill the pathogen using light of wavelength between 100 nm and 450 nm.
摘要翻译： 本发明涉及从患者的血液中除去病原体等病原体。 具体而言，本发明涉及使用涂覆材料来捕获期望从患者的血液中除去的疾病引发剂。 它还涉及使用特定波长的光灭活病原体。 光用于使用光敏剂活化活性氧物质，或者使用100nm至450nm波长的光直接杀死病原体。
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公开(公告)号：US07576334B2
公开(公告)日：2009-08-18
申请号：US12050493
申请日：2008-03-18
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , G01N21/1702 , G01N21/6428 , G01N29/2418 , G01N2021/6432
摘要： A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.
摘要翻译： 一种测量荧光团激发态寿命的方法，包括在染料处引发激发激光脉冲，以将染料的染料分子从基态激发至激发态，并在染料分子处引发探测脉冲，从而产生第一组光声波 第一时间延迟导致第一强度点。 可以重复该过程，可选地引入第二激发激光脉冲，以在第二时间延迟产生第二组光声波，从而产生第二强度点。 可以分析数据以确定第一强度点和第二强度点之间的斜率。
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公开(公告)号：US20080230717A1
公开(公告)日：2008-09-25
申请号：US12050493
申请日：2008-03-18
IPC分类号： G01J1/58
CPC分类号： G01N21/6408 , G01N21/1702 , G01N21/6428 , G01N29/2418 , G01N2021/6432
摘要： A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.
摘要翻译： 一种测量荧光团激发态寿命的方法，包括在染料处引发激发激光脉冲，以将染料的染料分子从基态激发至激发态，并在染料分子处引发探测脉冲，从而产生第一组光声波 第一时间延迟导致第一强度点。 可以重复该过程，可选地引入第二激发激光脉冲，以在第二时间延迟产生第二组光声波，从而产生第二强度点。 可以分析数据以确定第一强度点和第二强度点之间的斜率。
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公开(公告)号：US10512691B2
公开(公告)日：2019-12-24
申请号：US14396533
申请日：2013-04-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , Jerome Kalifa , Raoul Kopelman , Uma Mahesh R. Avula , Gwangseong Kim , Yong-Eun Koo Lee , Hyung Ki Yoon
发明人： Jerome Kalifa , Raoul Kopelman , Uma Mahesh R. Avula , Gwangseong Kim , Yong-Eun Koo Lee , Hyung Ki Yoon
IPC分类号： A61K51/00 , A61K41/00 , A61K31/5415 , A61K31/704 , A61K33/24 , A61K38/10 , A61K38/18 , A61K38/20 , A61K38/21 , A61K9/51
摘要： The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.
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公开(公告)号：US20150121808A1
公开(公告)日：2015-05-07
申请号：US14564042
申请日：2014-12-08
申请人： Angelo Gaitas , Gwangseong Kim
发明人： Angelo Gaitas , Gwangseong Kim
IPC分类号： A61M1/36
CPC分类号： A61M1/362 , A61M1/3679 , A61M1/3686 , B01D15/206
摘要： The present invention relates to removing disease material from the blood of a patient. Specifically, the invention relates to using biological binders to trap disease material that is desired to be removed from the blood of a patient.
摘要翻译： 本发明涉及从患者的血液中除去疾病物质。 具体而言，本发明涉及使用生物粘合剂来捕集期望从患者的血液中除去的疾病材料。
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