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公开(公告)号：US20130005736A1
公开(公告)日：2013-01-03
申请号：US13540865
申请日：2012-07-03
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: A61K31/501 , A61P31/14
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
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公开(公告)号：US20060089380A1
公开(公告)日：2006-04-27
申请号：US10521902
申请日：2003-07-16
Applicant: Kevin Barnham , Elisabeth Gautier , Gaik Kok , Guy Krippner
Inventor： Kevin Barnham , Elisabeth Gautier , Gaik Kok , Guy Krippner
IPC: A61K31/4709 , C07D215/38 , A61K31/47 , C07D401/02
CPC classification number: C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
Abstract: The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.
Abstract translation: 本发明涉及一种治疗，改善和/或预防神经系统疾病，特别是神经变性疾病的方法，其包括向有需要的受试者施用有效量的式（I）化合物。 本发明还涉及式（II）的化合物及其制备方法。
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公开(公告)号：US08975278B2
公开(公告)日：2015-03-10
申请号：US11901941
申请日：2007-09-19
Applicant: Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Guy Krippner
IPC: A01N43/42 , A61K31/47 , C07D215/00 , C07D215/38 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/26 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14
CPC classification number: C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
Abstract: The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
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公开(公告)号：US08217171B2
公开(公告)日：2012-07-10
申请号：US13100931
申请日：2011-05-04
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US20140328908A1
公开(公告)日：2014-11-06
申请号：US14238961
申请日：2012-08-16
Applicant: David Martin Kaye , Guy Krippner , Geetha Thanga Mariappan
Inventor： David Martin Kaye , Guy Krippner , Geetha Thanga Mariappan
IPC: A61K9/28 , A61K45/06 , A61K9/48 , A61K31/444
CPC classification number: A61K9/2866 , A61K9/2072 , A61K9/2886 , A61K9/4808 , A61K9/4891 , A61K31/444 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 μg/kg body weight/minute and 20 μg/kg body weight/minute.
Abstract translation: 本发明涉及5-（吡啶基）-2（1H） - 吡啶酮化合物的口服缓释制剂及其用于治疗患有心力衰竭，阶段，阶段或心脏衰竭表现或患有风险的受试者 发展或表现出心力衰竭症状。 本发明的制剂将化合物释放在0.1μg/ kg体重/分钟和20μg/ kg体重/分钟之间的范围内。
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Patent Agency Ranking
公开(公告)号：US20110212966A1
公开(公告)日：2011-09-01
申请号：US13100931
申请日：2011-05-04
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: A61K31/53 , C07D413/14 , A61K31/501 , A61P31/16 , A61K31/454
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US07951955B2
公开(公告)日：2011-05-31
申请号：US12113718
申请日：2008-05-01
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/16
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US07829705B2
公开(公告)日：2010-11-09
申请号：US11559253
申请日：2006-11-13
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4523 , A61K31/496 , A61K31/501 , A61P31/12
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US20070149530A1
公开(公告)日：2007-06-28
申请号：US11559242
申请日：2006-11-13
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: A61K31/501 , A61K31/496 , A61K31/495 , A61K31/497 , C07D417/14 , C07D413/14 , C07D403/14
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
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公开(公告)号：US07166604B2
公开(公告)日：2007-01-23
申请号：US10450005
申请日：2001-12-18
Applicant: Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
Inventor： Keith Watson , Guy Krippner , Pauline Stanislawski , Darryl McConnell
IPC: C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC classification number: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
Abstract: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals as well as novel intermediates useful in the preparation of the compounds of formula I
Abstract translation: 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途以及可用于制备式I化合物的新中间体
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