摘要:
The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6, R7 and R8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
摘要:
The present disclosure relates to Ethernet-over-Power and provides communication to and from the powerline hardware, e.g. power sockets or light fittings, and through the powerline itself. In one aspect a Power and Data transmission terminal that is a MAC addressable power outlet, switch or transition point is provided, the Power and Data transmission terminal having a PLC Transceiver, a microcontroller, a power consumption meter and a transmission router between the microcontroller and the PLC Transceiver, the system thereby being able to both monitor energy usage and allow data communication over the powerline with a single microcontroller at the or each Power and Data transmission terminal. The system provides I. P addresses to the electrical outlets from which a wide range of devices run and in so doing it can communicate with the electrical outlets themselves.
摘要:
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要:
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要:
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要:
The present invention provides a process for increasing the flavonoid content of a plant wherein said process comprises increasing the activity of chalcone synthase and flavonol synthase therein. The invention further relates to novel plants obtainable by the process of the invention and to food products made therefrom.
摘要:
A method for manipulating the production of flavonoids in tomatoes by expressing genes encoding chalcone isomerase, compositions for use in such a method and tomato plants having altered flavonoid levels are disclosed.
摘要:
A new seed-specific plant promoter is provided, capable of expressing a gene placed under control of said promoter before or during fatty acid or lipid biosynthesis in plant cells. In nature it occurs in the acyl carrier protein (ACP) gene. This opens the possibility of modifying the fatty acid synthesis in plants, which may result in changing the triacylglycerol composition of oil-containing seeds. Another option is the production of a desired protein in plants, either to improve the nutritional value of the seeds, or for the production of specific proteins that can be isolated from the fruits of plants.