公开(公告)号：US5210258A

公开(公告)日：1993-05-11

申请号：US875915

申请日：1992-04-29

Applicant: George C. Schloemer

Inventor： George C. Schloemer

IPC: C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/54 ,  C07C47/277 ,  C07C49/84 ,  C07C51/00 ,  C07C309/63 ,  C07D317/02 ,  C07D317/06 ,  C07D317/24 ,  C07F3/02 ,  C07F3/06 ,  C07F13/00

CPC classification number: C07F13/00 ,  C07C309/00 ,  C07C43/313 ,  C07C43/315 ,  C07C45/004 ,  C07C45/54 ,  C07C47/277 ,  C07C51/00 ,  C07D317/02 ,  C07D317/06 ,  C07D317/24 ,  C07F3/02 ,  C07F3/06

Abstract: Optically active naphthyl alpha-substituted alkyl ketones, are a class of ketones useful as intermediates in the production of optically active alpha-naphthylalkanoic acids which exhibit anti-inflammatory, analgesic and anti-pyretic activity.

Abstract translation: 光学活性的萘基α-取代的烷基酮是一类可用作生产光学活性α-萘基链烷酸的中间体的酮，其表现出抗炎，止痛和抗热解活性。

公开(公告)号：US4874871A

公开(公告)日：1989-10-17

申请号：US30774

申请日：1987-03-25

Applicant: Michael P. Fleming ,  George C. Schloemer ,  Hiralal N. Khatri

Inventor： Michael P. Fleming ,  George C. Schloemer ,  Hiralal N. Khatri

IPC: C07D207/32 ,  C07D207/337 ,  C07D487/04

CPC classification number: C07D207/337 ,  C07D487/04

Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds of the formula, ##STR1## in which Y is OH;O.sup.- M.sup.+, wherein M is an alkali metal; orNRR', wherein R is lower alkyl and R' is lower alkyl or aryl, or NRR' is the residue of a saturated cyclic amine,are prepared from pyrrole.

公开(公告)号：US4654438A

公开(公告)日：1987-03-31

申请号：US741655

申请日：1985-06-05

Applicant: George C. Schloemer

Inventor： George C. Schloemer

IPC: C07C41/48 ,  C07C43/315 ,  C07C45/29 ,  C07C45/46 ,  C07C45/63 ,  C07C49/76 ,  C07C51/00 ,  C07C69/76 ,  C07C53/134

CPC classification number: C07C51/00 ,  C07C41/48 ,  C07C43/315 ,  C07C45/29 ,  C07C45/46 ,  C07C45/63 ,  C07C49/76

Abstract: .alpha.-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an .alpha.-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the .alpha.-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding .alpha.-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding .alpha.-arylalkanoic acid.

Abstract translation: α-芳基链烷酸或其酯，原酸酯或酰胺通过形成芳基烷基酮的α-羟基缩酮或硫代缩酮来制备，用酯化剂活化α-羟基取代基以形成相应的缩酮或缩酮酸酯底物，其中 酯基团足够不稳定以在质子或偶极非质子溶剂中与底物非催化分离，保持酯底物与质子或偶极非质子溶剂或其混合物接触足以形成相应的α-芳基烷酸的时间 酸或酯，其原酸酯或酰胺，以及任选地伴随或依次水解形成于相应的α-芳基链烷酸的酯，原酸酯或酰胺。

公开(公告)号：US07291749B2

公开(公告)日：2007-11-06

申请号：US10685194

申请日：2003-10-14

Applicant: Mario D. Torres-Cardona ,  Gustavo Rodriquez ,  George C. Schloemer

Inventor： Mario D. Torres-Cardona ,  Gustavo Rodriquez ,  George C. Schloemer

IPC: C07C67/02

CPC classification number: C07C403/24

Abstract: A method is described for preparing astaxanthin esters from zeaxanthin by acylation of zeaxanthin with an acylating agent followed by contacting the esterified zeaxanthin with an oxidizing agent to produce esterified astaxanthin. The astaxanthin esters are more stable and show a better bioavailability than free astaxanthin when used in salmonid pigmentation.

Abstract translation: 描述了通过用酰化剂酰化玉米黄质，然后使酯化的玉米黄质与氧化剂接触以产生酯化的虾青素从玉米黄质制备虾青素的方法。 当用于鲑鱼色素沉着时，虾青素酯比游离虾青素更稳定，显示出更好的生物利用度。

公开(公告)号：US06372946B1

公开(公告)日：2002-04-16

申请号：US09953007

申请日：2001-09-13

Applicant: George C. Schloemer ,  Danuta A. Schloemer ,  Jeffery L. Davis

Inventor： George C. Schloemer ,  Danuta A. Schloemer ,  Jeffery L. Davis

IPC: C07C4500

CPC classification number: C07C403/24

Abstract: A method of preparing &bgr;-carotene derivatives such as canthaxanthin and astaxanthin is described. The method employs an in situ system to generate hypobromous acid as the oxidizing agent using a salt of sulfite, hydrogen sulfite or bisulfite in combination with a bromate salt. Astaxanthin and canthaxanthin are obtained in good yield with a significantly reduced reaction time.

Abstract translation: 描述了制备β-胡萝卜素衍生物如角黄素和虾青素的方法。 该方法采用原位系统，使用亚硫酸盐，亚硫酸氢盐或亚硫酸氢盐与溴酸盐的组合产生次溴酸作为氧化剂。 以良好的产率获得虾青素和角黄素，反应时间显着降低。

公开(公告)号：US06323344B1

公开(公告)日：2001-11-27

申请号：US09754529

申请日：2001-01-01

Applicant: Peter J. Harrington ,  Hiralal N. Khatri ,  George C. Schloemer

Inventor： Peter J. Harrington ,  Hiralal N. Khatri ,  George C. Schloemer

IPC: C07D20952

CPC classification number: C07D487/04

Abstract: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxamides of the formula where R1 is alkyl and R2 is optionally substituted phenyl; and the method for their preparation and their conversion to ketorolac and its pharmaceutically acceptable salts.

Abstract translation: 式R 1的5-苯甲酰基-2,3-二氢-1H-吡咯嗪-1-甲酰胺是烷基，R 2是任选取代的苯基; 及其制备方法及其转化为酮咯酸及其药学上可接受的盐。

公开(公告)号：US4937368A

公开(公告)日：1990-06-26

申请号：US299701

申请日：1989-01-23

Applicant: Hiralal N. Khatri ,  Michael P. Fleming ,  George C. Schloemer

Inventor： Hiralal N. Khatri ,  Michael P. Fleming ,  George C. Schloemer

IPC: C07D207/22 ,  C07D207/34 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D207/22 ,  C07D207/34

Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from from di(lower alkyl) 1,3-acetone-dicarboxylates.

Abstract translation: 由下式制备的2,3-二氢-1H-吡咯并[1,2-a]吡咯-1,7-二羧酸酯，其中每个R独立地为H或低级烷基，其中每个R独立地为H或低级烷基，由二（低级烷基） 1,3-丙酮 - 二羧酸酯。

公开(公告)号：US4835288A

公开(公告)日：1989-05-30

申请号：US3162

申请日：1987-01-14

Applicant: Hiralal N. Khatri ,  Michael P. Fleming ,  George C. Schloemer

Inventor： Hiralal N. Khatri ,  Michael P. Fleming ,  George C. Schloemer

IPC: C07D207/22 ,  C07D207/34 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D207/22 ,  C07D207/34

Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetone-dicarboxylates.

Abstract translation: 由下式制备的2,3-二氢-1H-吡咯并[1,2-a]吡咯-1,7-二羧酸酯，其中每个R独立地为H或低级烷基，其中每个R独立地为H或低级烷基，由二（低级烷基）1 ，3-丙酮 - 二羧酸酯。

公开(公告)号：US4605758A

公开(公告)日：1986-08-12

申请号：US602834

申请日：1984-04-23

Applicant: George C. Schloemer

Inventor： George C. Schloemer

IPC: C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/54 ,  C07C47/277 ,  C07C51/00 ,  C07C51/16 ,  C07D317/02 ,  C07D317/06 ,  C07D317/24 ,  C07F3/02 ,  C07F3/06 ,  C07F13/00

CPC classification number: C07F13/00 ,  C07C309/00 ,  C07C43/313 ,  C07C43/315 ,  C07C45/004 ,  C07C45/54 ,  C07C47/277 ,  C07C51/00 ,  C07D317/02 ,  C07D317/06 ,  C07D317/24 ,  C07F3/02 ,  C07F3/06

Abstract: Pharmaceutically useful optically active .alpha.-arylalkanoic acids or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting an aryl magnesium Grignard reagent with an optically active .alpha.-substituted acyl halide to form the optically active aryl .alpha.-substituted alkyl ketone, which is ketalized and rearranged to the desired optically active .alpha.-arylalkanoic acid or the corresponding ester, ortho ester or amide. In an alternate embodiment, the aryl .alpha.-substituted alkyl ketone is reduced to the corresponding alkanol, which is rearranged to the .alpha.-arylalkanal. The alkanal so produced is converted to the desired optically active .alpha.-arylalkanoic acid by conventional methods.

公开(公告)号：US5565565A

公开(公告)日：1996-10-15

申请号：US286045

申请日：1994-08-04

Applicant: Eric Lodewijk ,  Yeun-Kwei Han ,  George C. Schloemer ,  Sam L. Nguyen

Inventor： Eric Lodewijk ,  Yeun-Kwei Han ,  George C. Schloemer ,  Sam L. Nguyen

IPC: C07D473/18 ,  A61K31/00 ,  A61K31/52 ,  A61K31/522 ,  A61P31/00 ,  A61P31/12 ,  B01J31/02 ,  C07B61/00 ,  C07D473/00

CPC classification number: C07D473/00

Abstract: The invention relates to efficient and selective processes for the synthesis of the antiviral N-9 substituted guanine compounds acyclovir and ganciclovir.

Abstract translation: 本发明涉及用于合成抗病毒N-9取代鸟嘌呤化合物阿昔洛韦和更昔洛韦的有效和选择性方法。