公开(公告)号：US20130005790A1

公开(公告)日：2013-01-03

申请号：US13500356

申请日：2010-10-07

Applicant: Andras Mravik ,  Imre Koehegyi ,  Laszlo Pongo ,  Balazs Volk ,  Gabor Nemeth ,  Jozsef Barkoczy ,  Kalman Nagy ,  Gyoergy Ruzsics ,  Judit Broda ,  Andras Dancso ,  Adrienn Keszthelyi ,  Jozsef Debreczeni

Inventor： Andras Mravik ,  Imre Koehegyi ,  Laszlo Pongo ,  Balazs Volk ,  Gabor Nemeth ,  Jozsef Barkoczy ,  Kalman Nagy ,  Gyoergy Ruzsics ,  Judit Broda ,  Andras Dancso ,  Adrienn Keszthelyi ,  Jozsef Debreczeni

IPC: C07D207/16 ,  A61P3/10 ,  A61K31/40

CPC classification number: C07D207/16

Abstract: The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.

Abstract translation: 本发明涉及新型维格列汀复合物用于制备式I的高纯度维格列汀和/或其药学上可接受的盐。 本发明的另外的目的是维格列汀和/或无定形和结晶形式，无水形式，无定形和结晶水合物，络合物的无定形和结晶溶剂合物的药学上可接受的复合物及其制备方法。 本发明的另一个目的是从本发明的维格列汀复合物制备的高纯度维格列汀及其药学上可接受的盐，其制备方法和含有维格列汀碱，药学上可接受的盐和/或配合物的药物组合物及其用途 治疗2型糖尿病（NIDDM）。 本发明提供药学上有利的高纯度维格列汀复合物。

公开(公告)号：US07965629B2

公开(公告)日：2011-06-21

申请号：US12394760

申请日：2009-02-27

Applicant: Benedek Kovacs ,  Gabor Nemeth ,  Zsolt Kenesi

Inventor： Benedek Kovacs ,  Gabor Nemeth ,  Zsolt Kenesi

IPC: H04L1/00

CPC classification number: H04L47/10 ,  H04L47/12 ,  H04L47/24 ,  H04L47/32

Abstract: A system, method and node for overload control in a network. The method includes the steps of receiving an incoming offer by a node, filtering the offer by an in-throttle to determine if the offer is permitted to be processed by the node prior to processing by the node, processing a permitted offer, and sending the processed offer to a designated target. After processing the permitted offer by the node, the offer may be further filtered prior to sending the offer to the designated target.

Abstract translation: 一种用于网络中过载控制的系统，方法和节点。 该方法包括以下步骤：接收节点的传入报价，通过节拍器过滤报价，以确定报文是否被节点处理之前被节点处理，处理允许报价，以及发送报文 向指定目标处理报价。 在处理节点允许的报价之后，可以在向所指定的目标发送报价之前进一步过滤报价。

公开(公告)号：US20100220587A1

公开(公告)日：2010-09-02

申请号：US12394760

申请日：2009-02-27

Applicant: Benedek Kovacs ,  Gabor Nemeth ,  Zsolt Kenesi

Inventor： Benedek Kovacs ,  Gabor Nemeth ,  Zsolt Kenesi

IPC: H04L12/26

CPC classification number: H04L47/10 ,  H04L47/12 ,  H04L47/24 ,  H04L47/32

Abstract: A system, method and node for overload control in a network. The method includes the steps of receiving an incoming offer by a node, filtering the offer by an in-throttle to determine if the offer is permitted to be processed by the node prior to processing by the node, processing a permitted offer, and sending the processed offer to a designated target. After processing the permitted offer by the node, the offer may be further filtered prior to sending the offer to the designated target.

Abstract translation: 一种用于网络中过载控制的系统，方法和节点。 该方法包括以下步骤：接收节点的传入报价，通过节拍器过滤报价，以确定报文是否被节点处理之前被节点处理，处理允许报价，以及发送报文 向指定目标处理报价。 在处理节点允许的报价之后，可以在向所指定的目标发送报价之前进一步过滤报价。

公开(公告)号：US5216023A

公开(公告)日：1993-06-01

申请号：US576393

申请日：1990-09-12

Applicant: Peter N. Literati ,  Gyorgy Keri ,  Maria Boross ,  Gabor Nemeth ,  Jeno Szilbereky ,  Ildiko Szilagyi

Inventor： Peter N. Literati ,  Gyorgy Keri ,  Maria Boross ,  Gabor Nemeth ,  Jeno Szilbereky ,  Ildiko Szilagyi

IPC: C07C219/08 ,  C07C233/38 ,  C07C233/49 ,  C07C279/14

CPC classification number: C07C219/08 ,  C07C233/38 ,  C07C233/49 ,  C07C279/14

Abstract: The compounds of the Formula (I) ##STR1## wherein R.sub.1 is a C.sub.18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOHX is 0, NH or C.sub.1-4 alkyl-N,Y is CONH.sub.2, COOH or COOMe, wherein Me is hydrogen metal, andR.sub.2 is a side chain of a any amino acid except L-GLU or L-ASP at .alpha.-position or a group of Formula--(CH.sub.2).sub.k --C.sub.6 H.sub.3 --(A).sub.2 (II),--(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --X--M (III) whereink is zero or an integer of 1,n is zero or an integer of 1 to 3,m is zero or an integer of 1 to 4,A is hydroxyl or one A is hydroxyl and the other A is hydrogen.M is H or R.sub.1 --CO andX and R.sub.1 are as defined aboveand their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.

Abstract translation: PCT No.PCT / HU90 / 00004 Sec。 371 1990年9月12日第 102（e）1990年9月12日PCT PCT 1990年1月16日PCT PCT。 出版物WO90 / 08130 （I）化合物其中R 1是含有至少两个双键的C 18-24链烯基，或 - （CH 2）n -CH（NH 2）m -COOH X 是0，NH或C 1-4烷基-N，Y是CONH 2，COOH或COOMe，其中Me是氢金属，R 2是在α-位上除了L-GLU或L-ASP之外的任何氨基酸的侧链，或 式（ - ） - （CH2）k-C6H3-（A）2（Ⅱ）， - （CH2）nX-（CH2）mXM（Ⅲ）其中k为零或整数为1，n为0或1 至3，m为0或1〜4的整数，A为羟基或A为羟基，A为氢。 M是H或R1-CO，X和R1如上定义，并且其具有酪氨酸激酶抑制剂活性的盐可用作抗肿瘤剂。

公开(公告)号：US09571401B2

公开(公告)日：2017-02-14

申请号：US14376584

申请日：2012-02-09

Applicant: Péter Kersch ,  Gabor Nemeth ,  Laszlo Toka

Inventor： Péter Kersch ,  Gabor Nemeth ,  Laszlo Toka

IPC: H04L12/803 ,  H04L12/911 ,  H04L12/26

CPC classification number: H04L47/125 ,  H04L43/0876 ,  H04L47/822 ,  H04L47/823

Abstract: A technique for predicting network load in a communication network is described. For multiple subscriptions, a network load snapshot is provided. The network load snapshot comprises multiple network load records. Each network load record reflects network load caused by an associated subscription in the network at a particular point of time. Each network load record comprises at least one network load value reflecting a network load caused by the corresponding subscription and at least one network load influencing factor reflecting a parameter associated with the subscription which has the potential of influencing the network load value. The network load snapshot is transformed into a predicted network load snapshot comprising at least one predicted network load record, each predicted network load record reflecting estimated network load caused by the corresponding subscription at a particular point of time in the future. The transformation of a network load snapshot into a corresponding predicted network load snapshot is done based on both the network load values and the associated network load influencing factors.

Abstract translation: 描述了一种用于预测通信网络中的网络负载的技术。 对于多个订阅，提供了网络加载快照。 网络负载快照包含多个网络负载记录。 每个网络负载记录反映在特定时间点由网络中的相关订阅引起的网络负载。 每个网络负载记录包括反映由相应订阅引起的网络负载的至少一个网络负载值和反映与订阅相关联的参数的至少一个网络负载影响因素，其具有影响网络负载值的潜力。 网络负载快照被转换成包括至少一个预测的网络负载记录的预测的网络负载快照，每个预测的网络负载记录反映在将来的特定时间点由对应的订阅引起的估计的网络负载。 基于网络负载值和相关网络负载影响因素，将网络负载快照转换为相应的预测网络负载快照。

公开(公告)号：US08877799B2

公开(公告)日：2014-11-04

申请号：US13500356

申请日：2010-10-07

Applicant: Andras Mravik ,  Imre Koehegyi ,  Laszlo Pongo ,  Balazs Volk ,  Gabor Nemeth ,  Jozsef Barkoczy ,  Kalman Nagy ,  Gyoergy Ruzsics ,  Judit Broda ,  Andras Dancso ,  Adrienn Keszthelyi ,  Jozsef Debreczeni

Inventor： Andras Mravik ,  Imre Koehegyi ,  Laszlo Pongo ,  Balazs Volk ,  Gabor Nemeth ,  Jozsef Barkoczy ,  Kalman Nagy ,  Gyoergy Ruzsics ,  Judit Broda ,  Andras Dancso ,  Adrienn Keszthelyi ,  Jozsef Debreczeni

IPC: C07D207/16

CPC classification number: C07D207/16

Abstract: The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.

Abstract translation: 本发明涉及新型维格列汀复合物用于制备式I的高纯度维格列汀和/或其药学上可接受的盐。 本发明的另外的目的是维格列汀和/或无定形和结晶形式，无水形式，无定形和结晶水合物，络合物的无定形和结晶溶剂合物的药学上可接受的复合物及其制备方法。 本发明的另一个目的是从本发明的维格列汀复合物制备的高纯度维格列汀及其药学上可接受的盐，其制备方法和含有维格列汀碱，药学上可接受的盐和/或配合物的药物组合物及其用途 治疗2型糖尿病（NIDDM）。 本发明提供药学上有利的高纯度维格列汀复合物。

公开(公告)号：US08170557B2

公开(公告)日：2012-05-01

申请号：US12525716

申请日：2007-02-08

Applicant: Andras Veres ,  Gabor Nemeth ,  Ferenc Kubinszky ,  Gergely Biczok ,  Peter Tarjan

Inventor： Andras Veres ,  Gabor Nemeth ,  Ferenc Kubinszky ,  Gergely Biczok ,  Peter Tarjan

IPC: H04W36/00

CPC classification number: H04W28/14 ,  H04W36/08 ,  H04W84/042

Abstract: A method of reducing buffer overflow in a cellular radio network caused by a transfer of data from a buffer in a first cell to a buffer in a second cell when a handover of mobile equipment from said first cell to said second cell occurs. The method comprises temporarily increasing an amount of temporary buffer space required to handle data transferred from the buffer of the first cell to the buffer of the second cell. In one embodiment of the method, prior to increasing the amount of temporary buffer space, the amount of temporary buffer space required is calculated.

Abstract translation: 发生当移动设备从所述第一小区切换到所述第二小区时，由数据从第一小区中的缓冲器传送到第二小区中的缓冲器而导致在蜂窝无线电网络中减少缓冲区溢出的方法。 该方法包括临时增加处理从第一小区的缓冲器传送到第二小区的缓冲器的数据所需的临时缓冲区空间量。 在该方法的一个实施例中，在增加临时缓冲区空间的量之前，计算所需的临时缓冲区空间量。

公开(公告)号：US08000237B1

公开(公告)日：2011-08-16

申请号：US12695734

申请日：2010-01-28

Applicant: Zsolt Kenesi ,  Gabor Nemeth ,  Benedek Kovacs

Inventor： Zsolt Kenesi ,  Gabor Nemeth ,  Benedek Kovacs

IPC: H04L12/26

CPC classification number: H04L47/10 ,  H04L47/11 ,  H04L47/215 ,  H04L47/24

Abstract: A throttle device is coupled with a central processing unit in a node for reducing traffic overload in a Next Generation Network (NGN). The device is coupled with a basic throttle with different levels of traffic priority and both are situated between a source node and a target node for processing traffic. When a traffic offer is received by the throttle, the throttle device by provisionally updating the basic throttle priority levels, determines whether to send the traffic offer on to the source node. If the provisional, traffic priority level is greater than a new traffic priority level the traffic is admitted and rejected if the updated priority level is less than the new traffic priority level.

Abstract translation: 节气门装置与节点中的中央处理单元耦合，以减少下一代网络（NGN）中的交通负荷。 该设备与具有不同级别的业务优先级的基本节流器相耦合，并且它们都位于源节点和用于处理业务的目标节点之间。 当通过节气门接收到交通报价时，节气门装置通过临时更新基本油门优先级来确定是否将交通报价发送到源节点。 如果临时流量优先级大于新的流量优先级，则如果更新的优先级小于新的流量优先级，流量被允许并被拒绝。

公开(公告)号：US20110030625A1

公开(公告)日：2011-02-10

申请号：US12909987

申请日：2010-10-22

Applicant: Leslie G. Hammer ,  Gabor Nemeth ,  George Mismas

Inventor： Leslie G. Hammer ,  Gabor Nemeth ,  George Mismas

IPC: F02B43/08

CPC classification number: F02M27/04 ,  F02M25/12 ,  Y02T10/121

Abstract: An apparatus for the production of ozone for an internal combustion engine comprising a non-conductive shell having a first and second opening which allows air to flow therethrough and first and second electrodes disposed inside the shell. The first electrode is spaced a distance from the second electrode, the first electrode having a smaller diameter than, and being aligned axially within the second electrode. The first electrode permits air to flow therethrough. A high voltage source is connected to the first and second electrode, the high voltage source capable of producing a voltage differential on the first and second electrodes sufficient to cause the production of ozone. A change from oxygen to ozone occurs in the air flowing through the apparatus. The shell is preferably cylindrical.

Abstract translation: 一种用于生产用于内燃机的臭氧的装置，包括具有允许空气流过其中的第一和第二开口的非导电壳体，以及设置在壳体内的第一和第二电极。 第一电极与第二电极隔开一定距离，第一电极具有比第二电极小的直径并且在轴向上对准的第二电极。 第一电极允许空气流过其中。 高电压源连接到第一和第二电极，高电压源能够在第一和第二电极上产生足以导致臭氧产生的电压差。 在通过设备的空气中发生氧气变为臭氧。 壳体优选为圆柱形。

公开(公告)号：US20100083939A1

公开(公告)日：2010-04-08

申请号：US12589426

申请日：2009-10-23

Applicant: Leslie G. Hammer ,  Gabor Nemeth

Inventor： Leslie G. Hammer ,  Gabor Nemeth

IPC: F02M27/04 ,  F01N3/02

CPC classification number: F02M27/04 ,  C01B13/11 ,  C01B2201/14 ,  C01B2201/62

Abstract: This invention is for a simple device for converting the oxygen in air to ozone which then passes into the combustion chamber of a diesel fueled engine. When this device is used the amount of energy obtained from the diesel is greatly increased.

Abstract translation: 本发明是用于将空气中的氧气转化为臭氧的简单装置，臭氧然后进入柴油发动机的燃烧室。 当使用该装置时，从柴油获得的能量的量大大增加。