公开(公告)号：US09937251B2

公开(公告)日：2018-04-10

申请号：US12808028

申请日：2008-12-22

申请人： Ricardo Tostes Gazzinelli ,  Rafael Polidoro Alves Barbosa ,  Braulia Costa Caetano ,  Alexandre de Magalhaes Vieira Machado ,  Oscar Bruna-Romero ,  Flavio Fonseca Guimaraes ,  Erica Araujo Mendes

发明人： Ricardo Tostes Gazzinelli ,  Rafael Polidoro Alves Barbosa ,  Braulia Costa Caetano ,  Alexandre de Magalhaes Vieira Machado ,  Oscar Bruna-Romero ,  Flavio Fonseca Guimaraes ,  Erica Araujo Mendes

IPC分类号： A61K39/012 ,  A61K39/00

CPC分类号： A61K39/012 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N2710/24143 ,  C12N2760/16011

摘要： The present invention concerns to recombinant influenza viruses and modified Vaccinia Ankara viruses (MVA), and to a process for construction of recombinant influenza viruses and modified vaccinia Ankara viruses (MVA) with genes that encode for the T. gondii parasite SAGI (MVA) and SAG2 (MVA and influenza) proteins, by means of a homologous recombination technique between two transfer vectors (for construction of MVA virus) and reverse genetics (for construction of influenza virus). Additionally, the present invention describes a vaccine composition using recombinant influenza viruses and modified vaccinia Ankara viruses (MVA), or recombinant adenoviruses and modified vaccinia Ankara viruses (MVA), for immunization against infections caused by the T. gondii parasite.

公开(公告)号：US20110045016A1

公开(公告)日：2011-02-24

申请号：US12808028

申请日：2008-12-22

申请人： Ricardo Tostes Gazzinelli ,  Rafael Polidoro Alves Barbosa ,  Braulia Costa Caetano ,  Alexandre de Magalhaes Vieira Machado ,  Oscar Bruna-Romero ,  Flavio Fonseca Guimaraes ,  Erica Araujo Mendes

发明人： Ricardo Tostes Gazzinelli ,  Rafael Polidoro Alves Barbosa ,  Braulia Costa Caetano ,  Alexandre de Magalhaes Vieira Machado ,  Oscar Bruna-Romero ,  Flavio Fonseca Guimaraes ,  Erica Araujo Mendes

IPC分类号： A61K39/002 ,  C12N15/74 ,  C12N7/01 ,  A61P33/02 ,  A61P37/04 ,  C12N15/87

CPC分类号： A61K39/012 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N2710/24143 ,  C12N2760/16011

摘要： The present invention concerns to recombinant influenza viruses and modified Vaccinia Ankara viruses (MVA), and to a process for construction of recombinant influenza viruses and modified vaccinia Ankara viruses (MVA) with genes that encode for the T. gondii parasite SAGI (MVA) and SAG2 (MVA and influenza) proteins, by means of a homologous recombination technique between two transfer vectors (for construction of MVA virus) and reverse genetics (for construction of influenza virus). Additionally, the present invention describes a vaccine composition using recombinant influenza viruses and modified vaccinia Ankara viruses (MVA), or recombinant adenoviruses and modified vaccinia Ankara viruses (MVA), for immunization against infections caused by the T. gondii parasite.

摘要翻译： 本发明涉及重组流感病毒和改良的牛痘安卡拉病毒（MVA），以及用于构建重组流感病毒和修饰的痘苗安卡拉病毒（MVA）的方法，其具有编码弓形虫寄生虫SAGI（MVA）和 SAG2（MVA和流感）蛋白，通过两个转移载体之间的同源重组技术（用于构建MVA病毒）和反向遗传学（用于构建流感病毒）。 另外，本发明描述了使用重组流感病毒和修饰的痘苗安卡拉病毒（MVA）或重组腺病毒和修饰的痘苗安卡拉病毒（MVA）的疫苗组合物，用于免疫针对由弓形虫寄生虫引起的感染。