公开(公告)号：US20090191122A1

公开(公告)日：2009-07-30

申请号：US12280079

申请日：2007-02-19

申请人： Josue Manuel Moreno Bermudez ,  Andreas Turler ,  Richard Henklemann ,  Eva Kabai ,  Ernst Huenges

发明人： Josue Manuel Moreno Bermudez ,  Andreas Turler ,  Richard Henklemann ,  Eva Kabai ,  Ernst Huenges

IPC分类号： A61K51/00 ,  C22B60/00

CPC分类号： C22B60/0295 ,  A61K51/00 ,  B01D15/206 ,  B01D15/26 ,  C22B7/005 ,  C22B7/007 ,  C22B7/009 ,  G21G1/001 ,  G21G4/08 ,  G21G2001/0089

摘要： The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support, comprising a leaching treatment of the 226Ra-targets for leaching essentially the entirety of 225Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotopes and a second extraction chromatography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.

摘要翻译： 本发明描述了一种用于从设置在载体上的辐照的226Rα-靶标纯化225Ac的方法，其包括用硝酸或盐酸浸提基本上整个225Ac和226Ra的226Ra-靶标的浸出处理，然后进行第一提取色谱 用于从226Ra和其他Ra同位素分离225Ac，以及用于从210Po和210Pb分离225Ac的第二提取色谱。 最终纯化的225Ac可用于制备用于制药目的的组合物。

公开(公告)号：US20120251415A1

公开(公告)日：2012-10-04

申请号：US13441803

申请日：2012-04-06

申请人： Eva KABAI ,  Josue M. MORENO BERMUDEZ ,  Richard HENKELMANN ,  Andreas Türler

发明人： Eva KABAI ,  Josue M. MORENO BERMUDEZ ,  Richard HENKELMANN ,  Andreas Türler

IPC分类号： C01F13/00

CPC分类号： C22B60/00 ,  C22B3/002 ,  C22B13/04 ,  C22B26/20 ,  G21G1/001 ,  G21G2001/0094 ,  Y02P10/234

摘要： The invention is directed to a method for the purification of Radium, in particular 226Ra, for target preparation for an essentially pure 225Ac production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is related to a method for recycling of 226Ra, for target preparation for 225Ac production from radium sources irradiated with accelerated protons (p,2n), after separation of the produced 225Ac. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtained 226Ra is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

摘要翻译： 本发明涉及一种用于纯化镭（特别是226Ra）的方法，用于使用提取色谱从化学上类似的元素如Ba，Sr和Pb分离用于从可用的放射源制备基本上纯的225Ac产物的目标制备 从所需的Ra; 其中所述提取色谱法具有基于冠醚的萃取剂体系。 本发明涉及一种用于回收226Ra的方法，用于在分离产生的225Ac之后，用加速质子（p，2n）照射的镭源进行225Ac生产的目标制备。 在该方法中，使用上述提取色谱和阳离子交换层析的组合。 得到的226Ra基本上不含由Ag，Al，As，Be，Bi，Ca，Cd，Co，Cr，Cu，Fe，Ga，K，Li，Mg，Mn，Na，Ni，Pb组成的以下化学污染物 ，Sr，V，Zn和Ba。

公开(公告)号：US08715598B2

公开(公告)日：2014-05-06

申请号：US13441803

申请日：2012-04-06

申请人： Eva Kabai ,  Josue M. Moreno Bermudez ,  Richard Henkelmann ,  Andreas Türler

发明人： Eva Kabai ,  Josue M. Moreno Bermudez ,  Richard Henkelmann ,  Andreas Türler

IPC分类号： C01F13/00

CPC分类号： C22B60/00 ,  C22B3/002 ,  C22B13/04 ,  C22B26/20 ,  G21G1/001 ,  G21G2001/0094 ,  Y02P10/234

摘要： The invention is directed to a method for the purification of Radium, in particular 226Ra, for target preparation for an essentially pure 225Ac production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is related to a method for recycling of 226Ra, for target preparation for 225Ac production from radium sources irradiated with accelerated protons (p,2n), after separation of the produced 225Ac. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtained 226Ra is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

摘要翻译： 本发明涉及一种用于纯化镭（特别是226Ra）的方法，用于使用提取色谱从化学上类似的元素如Ba，Sr和Pb分离用于从可用的放射源制备基本上纯的225Ac产物的目标制备 从所需的Ra; 其中所述提取色谱法具有基于冠醚的萃取剂体系。 本发明涉及一种用于回收226Ra的方法，用于在分离产生的225Ac之后，用加速质子（p，2n）照射的镭源进行225Ac生产的目标制备。 在该方法中，使用上述提取色谱和阳离子交换层析的组合。 得到的226Ra基本上不含由Ag，Al，As，Be，Bi，Ca，Cd，Co，Cr，Cu，Fe，Ga，K，Li，Mg，Mn，Na，Ni，Pb组成的以下化学污染物 ，Sr，V，Zn和Ba。

公开(公告)号：US08153087B2

公开(公告)日：2012-04-10

申请号：US12398346

申请日：2009-03-05

申请人： Eva Kabai ,  Josue Manuel Moreno Bermudez ,  Richard Henkelmann ,  Andreas Turler

发明人： Eva Kabai ,  Josue Manuel Moreno Bermudez ,  Richard Henkelmann ,  Andreas Turler

IPC分类号： C01F13/00

CPC分类号： C22B60/00 ,  C22B3/002 ,  C22B13/04 ,  C22B26/20 ,  G21G1/001 ,  G21G2001/0094 ,  Y02P10/234

摘要： The present application is directed to a method for the purification of Radium, in particular 226Ra, for target preparation for an essentially pure 225Ac production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is further related to a method for recycling of 226Ra, for target preparation for 225Ac production from radium sources irradiated with accelerated protons (p,2n), after separation of the produced 225AC. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtained 226Ra is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

摘要翻译： 本申请涉及用于纯化镭（特别是226Ra）的方法，用于使用提取色谱法将化学上类似的元素如Ba，Sr和 Pb从所需的Ra; 其中所述提取色谱法具有基于冠醚的萃取剂体系。 本发明进一步涉及一种用于回收226Ra的方法，用于在分离生成的225AC之后，用加速质子（p，2n）照射的镭源的225Ac生产的目标制备。 在该方法中，使用上述提取色谱和阳离子交换层析的组合。 得到的226Ra基本上不含由Ag，Al，As，Be，Bi，Ca，Cd，Co，Cr，Cu，Fe，Ga，K，Li，Mg，Mn，Na，Ni，Pb组成的以下化学污染物 ，Sr，V，Zn和Ba。

公开(公告)号：US20100104489A1

公开(公告)日：2010-04-29

申请号：US12398346

申请日：2009-03-05

申请人： Eva Kabai ,  Josue M. Moreno Bermudez ,  Richard Henklemann ,  Andreas Turler

发明人： Eva Kabai ,  Josue M. Moreno Bermudez ,  Richard Henklemann ,  Andreas Turler

IPC分类号： C01F13/00

CPC分类号： C22B60/00 ,  C22B3/002 ,  C22B13/04 ,  C22B26/20 ,  G21G1/001 ,  G21G2001/0094 ,  Y02P10/234

摘要： The present application is directed to a method for the purification of Radium, in particular 226Ra, for target preparation for an essentially pure 225Ac production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is further related to a method for recycling of 226Ra, for target preparation for 225Ac production from radium sources irradiated with accelerated protons (p,2n), after separation of the produced 225AC. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtained 226Ra is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

摘要翻译： 本申请涉及用于纯化镭（特别是226Ra）的方法，用于使用提取色谱法将化学上类似的元素如Ba，Sr和 Pb从所需的Ra; 其中所述提取色谱法具有基于冠醚的萃取剂体系。 本发明进一步涉及一种用于回收226Ra的方法，用于在分离生成的225AC之后，用加速质子（p，2n）照射的镭源的225Ac生产的目标制备。 在该方法中，使用上述提取色谱和阳离子交换层析的组合。 得到的226Ra基本上不含由Ag，Al，As，Be，Bi，Ca，Cd，Co，Cr，Cu，Fe，Ga，K，Li，Mg，Mn，Na，Ni，Pb组成的以下化学污染物 ，Sr，V，Zn和Ba。