-
![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2007/12/18/US07309717B2/abs.jpg.150x150.jpg)
1.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07309717B2
公开(公告)日：2007-12-18
申请号：US10867602
申请日：2004-06-15
申请人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： A61K31/21 , C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
-
公开(公告)号：US06262270B1
公开(公告)日：2001-07-17
申请号：US09371172
申请日：1999-08-11
申请人： Richard W. Draper , Radha V. Iyer , Yuelie Lu , Eugene J. Vater
发明人： Richard W. Draper , Radha V. Iyer , Yuelie Lu , Eugene J. Vater
IPC分类号： C07D40510
CPC分类号： C07D311/26
摘要： A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula I or XIV or a pharmaceutically acceptable salt thereof.
摘要翻译： 用于有效对映选择性合成式I或XIV的非甾体抗雌激素的短暂的实用商业方法或其药学上可接受的盐。
-
3.发明申请PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE 审中-公开3-氨基-3-（环戊基甲基）-2-（羟基） - 丙二酸氢氯化物的制备公开(公告)号：US20100113821A1
公开(公告)日：2010-05-06
申请号：US12519486
申请日：2007-12-17
申请人： Jeonghan Park , Eugene J. Vater , Shuan Dong , Tetsuo Iwama , Ramani R. Raghavan , Hong-Chang Lee , George S.k. Wong
发明人： Jeonghan Park , Eugene J. Vater , Shuan Dong , Tetsuo Iwama , Ramani R. Raghavan , Hong-Chang Lee , George S.k. Wong
IPC分类号： C07C69/74 , C07C229/02 , C07C237/14 , C07C205/15 , C07C205/02
CPC分类号： C07C1/26 , C07C17/10 , C07C2529/40 , C07C9/00 , C07C19/075
摘要： Disclosed is a process for preparing 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide hydrochloride, an intermediate useful in the preparation of the HCV protease inhibitor (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide.
摘要翻译： 公开了制备3-（氨基）-3-环丁基甲基-2-羟基 - 丙酰胺盐酸盐的方法，其可用于制备HCV蛋白酶抑制剂（1R，5S）-N- [3-氨基-1-（ 羰基]氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基-1-氧代丁基〕-3-〔2（S） - 〔〔〔（1,1-二甲基乙基） 二甲基-3-氮杂双环[3.1.0]己烷-2（S） - 甲酰胺。
-
![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2010/06/01/US07728165B2/abs.jpg.150x150.jpg)
4.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 失效制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07728165B2
公开(公告)日：2010-06-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C69/01 , C07C211/17 , C07C235/02
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
-
![PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF](/abs-image/US/2009/10/01/US20090247784A1/abs.jpg.150x150.jpg)
5.发明申请PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF 失效（1R，2S，5S）-6,6-二甲基-3-亚氨基] [3,1,0]庚烷-2-羧酸酯或其盐的制备方法和中间体公开(公告)号：US20090247784A1
公开(公告)日：2009-10-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C61/04 , C07C229/38
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
-
6.发明授权Process for preparation of 9.alpha.-chloro-11.beta.-formyloxypregna-3,20-diones 失效制备9α-chlor-11β-甲氧基孕激素-3,20-二氢睾酮的方法
公开(公告)号：US5602248A
公开(公告)日：1997-02-11
申请号：US405110
申请日：1995-03-16
申请人： Richard W. Draper , Eugene J. Vater
发明人： Richard W. Draper , Eugene J. Vater
CPC分类号： C07J7/0085 , C07J17/00
摘要： Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethyl formamide; at a temperature within the range of about -78.degree. to about 0.degree. C., under anhydrous conditions under an inert atmosphere.
摘要翻译： 公开了下式化合物的制备方法：将下式化合物（2.0）与下列化合物反应：（1）选自N-氯代酰亚胺或N-酰氯的氯化试剂， 氯代酰胺; （2）选自正磷酸，烷基磺酸，氟烷基磺酸或芳基磺酸的无水强酸; 和（3）无水二甲基甲酰胺; 在约-78℃至约0℃的温度下，在无水条件下，在惰性气氛下。
-
![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof](/abs-image/US/2009/08/04/US07569705B2/abs.jpg.150x150.jpg)
7.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof 失效其制备用于其盐的（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐的方法和中间体公开(公告)号：US07569705B2
公开(公告)日：2009-08-04
申请号：US11982875
申请日：2007-11-06
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
-
8.发明授权Process for preparation of 9.alpha. -chloro-11.beta. formyloxypregna-3.20-diones 失效制备9α-chlor-11β甲酰孕激素-3.20-二酮的方法
公开(公告)号：US5670676A
公开(公告)日：1997-09-23
申请号：US455967
申请日：1995-05-31
申请人： Richard W. Draper , Eugene J. Vater
发明人： Richard W. Draper , Eugene J. Vater
CPC分类号： C07J31/006 , C07J5/0076
摘要： Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethylformamide; at a temperature within the range of about -78.degree. to about 0.degree. C.
摘要翻译： 公开了下式化合物的制备方法：通过使下式化合物与下列化合物反应：（1）选自N-氯代酰胺或N-氯代酰胺的氯化试剂; （2）选自正磷酸，烷基磺酸，氟烷基磺酸或芳基磺酸的无水强酸; 和（3）无水二甲基甲酰胺; 在约-78℃至约0℃的温度范围内
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.016 秒)
