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公开(公告)号：US20130273030A1
公开(公告)日：2013-10-17
申请号：US13747319
申请日：2013-01-22
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K31/519 , A61K31/4184 , A61K45/06 , A61K31/7076 , A61K31/454 , A61K31/704 , A61K31/437 , A61K31/573 , A61K31/337 , A61K39/395 , A61K31/675
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/4866 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：US20130202611A1
公开(公告)日：2013-08-08
申请号：US13736812
申请日：2013-01-08
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： C07D487/04 , A61K45/06 , A61K31/519
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/4866 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：US20100266589A1
公开(公告)日：2010-10-21
申请号：US12763704
申请日：2010-04-20
申请人： Eric Hedrick , Robert D. Mass , Gwendolyn Fyfe , Norman Wolmark
发明人： Eric Hedrick , Robert D. Mass , Gwendolyn Fyfe , Norman Wolmark
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545
摘要： Disclosed herein are methods and compostions comprising anti-VEGF antibodies for use in adjuvant cancer therapy.
摘要翻译： 本文公开了包含用于辅助癌症治疗的抗VEGF抗体的方法和组合物。
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公开(公告)号：US20120183535A1
公开(公告)日：2012-07-19
申请号：US13340522
申请日：2011-12-29
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K31/519 , A61K39/395 , A61K31/7068 , A61K31/7076 , A61P35/00 , A61K31/704 , A61K31/69 , A61K31/664
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：US20130310402A1
公开(公告)日：2013-11-21
申请号：US13869700
申请日：2013-04-24
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/4866 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：US20120100138A1
公开(公告)日：2012-04-26
申请号：US13340533
申请日：2011-12-29
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K31/519 , A61P35/00 , A61P35/02 , A61K39/395
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/4866 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
摘要翻译： 本文公开了治疗癌症的方法，包括：a。 对受试者施用Btk抑制剂足以导致免疫表型定义的淋巴细胞亚群的血液增加或出现; b。 确定来自一个或多个淋巴细胞亚群的一种或多种生物标志物的表达谱; 和c。 基于所确定的表达谱来施用第二试剂。
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公开(公告)号：US20130195852A1
公开(公告)日：2013-08-01
申请号：US13747322
申请日：2013-01-22
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K31/519 , A61K31/7032 , A61K31/7076 , A61K31/4745 , A61K31/573 , A61K45/06 , A61K31/4184 , A61K39/395 , A61K31/675
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：US20120087915A1
公开(公告)日：2012-04-12
申请号：US13153317
申请日：2011-06-03
申请人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
发明人： Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
IPC分类号： A61K39/395 , A61K31/704 , A61K31/7052 , A61K31/7076 , A61P35/00 , A61K31/675 , A61K31/56 , A61K31/5383 , A61K31/519 , A61P35/02 , A61K38/00 , A61K31/69
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/4866 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
摘要翻译： 本文公开了治疗癌症的方法，包括：a。 对受试者施用Btk抑制剂足以导致免疫表型定义的淋巴细胞亚群的血液增加或出现; b。 确定来自一个或多个淋巴细胞亚群的一种或多种生物标志物的表达谱; 和c。 基于所确定的表达谱来施用第二试剂。
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