公开(公告)号：US09040503B2

公开(公告)日：2015-05-26

申请号：US13380219

申请日：2010-07-02

Applicant: Betty Jin ,  Paul Arthur Jones ,  Ee Ling Seah ,  Wen Yang Wu ,  Peter James Jenkins

Inventor： Betty Jin ,  Paul Arthur Jones ,  Ee Ling Seah ,  Wen Yang Wu ,  Peter James Jenkins

IPC: A61K31/70 ,  A61K31/7008 ,  A61K31/7012

CPC classification number: A61K31/7028 ,  A61K9/007 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/7068 ,  A61P11/00

Abstract: A method of promoting recovery of cell viability of a damaged respiratory cell. The method includes a step of administering to the cell at least one pharmaceutically acceptable compound, which accelerates sialyglycoconjugate biosynthesis to restore sialylglycoconjugates on the surface of the respiratory cell. Also disclosed are a method and a pharmaceutical composition, both for treating a respiratory condition.

Abstract translation: 促进受损呼吸细胞的细胞活力恢复的方法。 该方法包括向细胞施用至少一种药学上可接受的化合物的步骤，其加速唾液酸糖缀合物的生物合成以恢复呼吸细胞表面上的唾液酸糖缀合物。 还公开了用于治疗呼吸状况的方法和药物组合物。

公开(公告)号：US20120142619A1

公开(公告)日：2012-06-07

申请号：US13380219

申请日：2010-07-02

Applicant: Betty Jin ,  Paul Arthur Jones ,  Ee Ling Seah ,  Wen Yang Wu ,  Peter James Jenkins

Inventor： Betty Jin ,  Paul Arthur Jones ,  Ee Ling Seah ,  Wen Yang Wu ,  Peter James Jenkins

IPC: A61K31/7028 ,  C07H15/12 ,  A61P11/00 ,  C07H15/04 ,  C12N5/071 ,  A61K31/7012 ,  A61K31/7068 ,  C07H19/10 ,  A61K31/7008 ,  A61P29/00

CPC classification number: A61K31/7028 ,  A61K9/007 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/7068 ,  A61P11/00

Abstract: The present invention relates to a method and compounds of Formula (1) and/or (2) or their pharmaceutically acceptable inorganic or organic salt thereof, and their compositions for treating respiratory conditions including post viral/bacterial infections, acute/chronic bronchitis, COPD, cystic fibrosis, and inflammatory conditions. It has been found by the applicants that the compounds of Formula (1) and/or (2) or their pharmaceutically acceptable inorganic or organic salt thereof could speed up the recovery of the viability of damaged respiratory tract cells by restoring sialylglyco-conjugates on their surface.

Abstract translation: 本发明涉及式（1）和/或（2）的化合物或其药学上可接受的无机或有机盐及其组合物，用于治疗包括病毒/细菌感染，急性/慢性支气管炎，COPD ，囊性纤维化和炎性病症。 申请人已经发现，式（1）和/或（2）的化合物或其药学上可接受的无机或有机盐可以通过将唾液酸糖缀合物恢复在其上来加速受损呼吸道细胞活力的恢复 表面。