PRODUCTION AND USE OF BACTERIAL HISTAMINE
    10.
    发明申请
    PRODUCTION AND USE OF BACTERIAL HISTAMINE 审中-公开
    生物和使用细菌组胺

    公开(公告)号:US20130149291A1

    公开(公告)日:2013-06-13

    申请号:US13765947

    申请日:2013-02-13

    IPC分类号: A61K35/74 A61K31/4172

    摘要: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an. active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production, of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

    摘要翻译: 提供了选择产生组胺的特定益生菌乳酸菌的方法以及这些菌株对哺乳动物的有益作用的使用。 该方法包括选择用于哺乳动物中组胺局部生产的乳酸菌株,并且进一步包括筛选细菌的存在。 活性组氨酸操纵子,选择具有活性组氨酸操纵子并能够产生组胺的菌株。 优选地,选择所述菌株以其大于250pg / ml的水平产生组胺的能力。 本发明还提供了包含可通过本发明的选择方法获得的用于局部生产的哺乳动物组胺的产品,特别是用于治疗或预防炎性病症的产品。