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    CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS
    1.
    发明申请
    CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS 审中-公开
    CSF-1R抑制剂治疗脑肿瘤

    公开(公告)号：US20140065141A1

    公开(公告)日：2014-03-06

    申请号：US14114878

    申请日：2012-05-04

    Applicant: Dylan Daniel ,  Johanna Joyce ,  James Sutton

    Inventor： Dylan Daniel ,  Johanna Joyce ,  James Sutton

    IPC: A61K31/4439 ,  A61K45/06 ,  A61K31/175 ,  A61K31/675 ,  A61K39/395 ,  A61K31/4545

    CPC classification number: A61K31/4439 ,  A61K31/175 ,  A61K31/4545 ,  A61K31/675 ,  A61K39/3955 ,  A61K45/06 ,  C07D417/12 ,  C07D417/14

    Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

    Abstract translation: 本发明提供式I化合物; 其中R1是烷基吡唑或烷基甲酰胺，R2是羟基环烷基; 或其药学上可接受的盐，以及含有这些化合物的组合物，用于治疗脑肿瘤，特别是成胶质细胞瘤。 本发明提供对脑肿瘤的有效治疗，并且可以通过口服施用本文进一步描述的式I化合物来使用。 本发明还提供了治疗具有脑肿瘤如胶质母细胞瘤的受试者的方法，其中所述方法包括给予受试者有效量的式I化合物。还公开了使用这些方法与成功治疗相关的基因标记。

    CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS
    3.
    发明申请
    CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS 审中-公开
    CSF-1R抑制剂治疗脑肿瘤

    公开(公告)号：US20150306085A1

    公开(公告)日：2015-10-29

    申请号：US14754152

    申请日：2015-06-29

    Applicant: Dylan DANIEL ,  Johanna JOYCE ,  James SUTTON

    Inventor： Dylan DANIEL ,  Johanna JOYCE ,  James SUTTON

    IPC: A61K31/4439 ,  A61K45/06 ,  C07D417/12

    CPC classification number: A61K31/4439 ,  A61K31/175 ,  A61K31/4545 ,  A61K31/675 ,  A61K39/3955 ,  A61K45/06 ,  C07D417/12 ,  C07D417/14

    Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

    Abstract translation: 本发明提供式I化合物; 其中R1是烷基吡唑或烷基甲酰胺，R2是羟基环烷基; 或其药学上可接受的盐，以及含有这些化合物的组合物，用于治疗脑肿瘤，特别是成胶质细胞瘤。 本发明提供对脑肿瘤的有效治疗，并且可以通过口服施用本文进一步描述的式I化合物来使用。 本发明还提供了治疗具有脑肿瘤如胶质母细胞瘤的受试者的方法，其中所述方法包括给予受试者有效量的式I化合物。还公开了使用这些方法与成功治疗相关的基因标记。

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