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    COMPOSITIONS AND METHODS FOR STABILIZED POLYSACCHARIDE FORMULATIONS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR STABILIZED POLYSACCHARIDE FORMULATIONS 有权
    稳定多糖制剂的组合物和方法

    公开(公告)号：US20130005681A1

    公开(公告)日：2013-01-03

    申请号：US13173658

    申请日：2011-06-30

    Applicant: Dongling Su ,  Julia Hwang ,  Brooks J. Story

    Inventor： Dongling Su ,  Julia Hwang ,  Brooks J. Story

    IPC: A61K31/728 ,  A61P29/00 ,  A61P19/04 ,  A61P19/02

    CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/726 ,  A61K31/728 ,  A61K31/737 ,  A61K47/02 ,  A61K47/10 ,  A61K2300/00

    Abstract: Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluronic acid (“HA”), in combination with at least one stabilizer. The composition can include a stabilizer that increases the stability and shelf-life of the HA. In another embodiment, the compositions and methods can also include an additional component, such as one or more glycosaminoglycans (“GAG”) or GAG precursors. Examples of GAGs or GAG precursors can include chondroitin sulfate (“CS”), dermatan sulfate, heparin, heparan sulfate, keratan sulfate, and glucosamine (“GlcN”).

    Abstract translation: 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（HA）与至少一种稳定剂的组合。 组合物可以包括增加HA的稳定性和保质期的稳定剂。 在另一个实施方案中，组合物和方法还可以包括另外的组分，例如一种或多种糖胺聚糖（GAG）或GAG前体。 GAG或GAG前体的实例可包括硫酸软骨素（CS），硫酸皮肤素，肝素，硫酸乙酰肝素，硫酸角质素和葡糖胺（GlcN）。

    Liquid buffered GDF-5 formulations
    4.
    发明授权
    Liquid buffered GDF-5 formulations 有权
    液体缓冲GDF-5制剂

    公开(公告)号：US07947649B2

    公开(公告)日：2011-05-24

    申请号：US12420260

    申请日：2009-04-08

    Applicant: Dongling Su ,  Julius Lopez

    Inventor： Dongling Su ,  Julius Lopez

    IPC: A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475

    CPC classification number: A61K9/0019 ,  A61K38/1875 ,  A61K47/12

    Abstract: Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein the solution has a pH of from about 4.2 to about 5.3, thereby providing for a biologically isotonic solution having improved stability of the GDF-5 protein during storage, handling, and use.

    Abstract translation: 提供改进的制剂和方法用于稳定骨形态发生蛋白的溶液。 所述组合物包含GDF-5和其它赋形剂的乙酸盐缓冲溶液，其中所述溶液的pH为约4.2至约5.3，从而提供具有改善的GDF-5蛋白在储存，处理和/或储存期间的稳定性的生物等渗溶液 使用。

    Compositions and methods for treating joints
    5.
    发明授权
    Compositions and methods for treating joints 有权
    用于治疗关节的组合物和方法

    公开(公告)号：US08524662B2

    公开(公告)日：2013-09-03

    申请号：US12979972

    申请日：2010-12-28

    Applicant: Ben Byers ,  Dongling Su ,  Julia Hwang

    Inventor： Ben Byers ,  Dongling Su ,  Julia Hwang

    IPC: A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19

    CPC classification number: A61K31/728 ,  A61K38/1875 ,  A61K2300/00

    Abstract: Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.

    Abstract translation: 公开了用于治疗骨关节炎的关节内注射的方法和组合物。 包括透明质酸和骨形态发生蛋白（如rhGDF-5）的组合的方法和组合物可用于任何滑膜关节，包括膝盖，肩部，髋，踝，踝关节，手，脊柱小面或颞下颌关节， 缓解疼痛和减缓疾病进展。

    COMPOSITIONS AND METHODS FOR TREATING JOINTS
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING JOINTS 有权
    组合物和处理接头的方法

    公开(公告)号：US20120165787A1

    公开(公告)日：2012-06-28

    申请号：US12979981

    申请日：2010-12-28

    Applicant: Julia Hwang ,  Dongling Su ,  Julius Lopez

    Inventor： Julia Hwang ,  Dongling Su ,  Julius Lopez

    IPC: A61M5/31 ,  A61K31/737 ,  A61P19/02 ,  A61K31/728

    CPC classification number: A61K31/728 ,  A61K9/0019 ,  A61K31/7008 ,  A61K31/737 ,  A61M5/19 ,  A61M5/2066 ,  A61K2300/00

    Abstract: Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”)

    Abstract translation: 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（“HA”）与冻干的第二组分组合，其有效地至少暂时降低HA的粘度。 在一个示例性实施方案中，第二组分是一种或多种糖胺聚糖（“GAG”），例如硫酸软骨素（“CS”），包括CS4和/或CS6，硫酸皮肤素，肝素，硫酸乙酰肝素和硫酸角质素。 组合物可任选地包括其它联合补充剂，例如葡糖胺（“GlcN”）

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