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公开(公告)号：US08461167B2
公开(公告)日：2013-06-11
申请号：US12227002
申请日：2007-05-08
Applicant: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
Inventor： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC: A01N43/54 , A61K31/505 , C07D239/02
CPC classification number: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US20130005738A1
公开(公告)日：2013-01-03
申请号：US13612067
申请日：2012-09-12
Applicant: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
Inventor： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC: C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC classification number: C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
Applicant: Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
Inventor： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC: A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC classification number: C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
Abstract: The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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![Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors](/abs-image/US/2012/02/14/US08114874B2/abs.jpg.150x150.jpg)
4.发明授权Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors 有权取代的炔属咪唑并[1,2-B]哒嗪化合物作为激酶抑制剂公开(公告)号：US08114874B2
公开(公告)日：2012-02-14
申请号：US11644849
申请日：2006-12-22
Applicant: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
Inventor： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC: A61K31/495
CPC classification number: C07D471/04 , C07D473/34 , C07D487/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。 特别地，化合物包括其中环T是咪唑并[1,2-b]哒嗪环体系的实施方案，环A和B各自为芳基且L 1为-C（O）NR 1 - 或-NR 1 C（O） - 。 用于化合物和含有它们的组合物的用途包括治疗由蛋白激酶介导的癌症和其它疾病。
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公开(公告)号：US07427144B2
公开(公告)日：2008-09-23
申请号：US11505561
申请日：2006-08-16
Applicant: Shao-Han Chang , Li-Zhou Shi , Hua-Dong Zou , Yu-Ya Liu
Inventor： Shao-Han Chang , Li-Zhou Shi , Hua-Dong Zou , Yu-Ya Liu
CPC classification number: G02F1/133608 , G02F1/133604
Abstract: A direct type backlight module (30) includes a base (21), at least two lamp-fixing units (22) and at least one lamp tube (20). Each lamp-fixing unit is disposed on each corresponding opposite ends of the base. Each lamp-fixing unit includes a bottom board (222) and at least one clip element (224) formed on the bottom board. The lamp tube includes two electrodes defined at two ends thereof and two electrode holders (202) receiving the two electrodes respectively. The electrode holders of the lamp tube are fixed in the corresponding clip elements of the two lamp-fixing units, thus the lamp tube are mounted into the two aligned lamp-fixing units. In the present backlight module, the lamp tubes can be fixed into the clip elements tightly and also easily dissembled from the clip elements of the lamp-fixing units.
Abstract translation: 直接型背光模块（30）包括基座（21），至少两个灯固定单元（22）和至少一个灯管（20）。 每个灯固定单元设置在基座的每个对应的相对端。 每个灯固定单元包括底板（222）和形成在底板上的至少一个夹子元件（224）。 灯管包括在其两端限定的两个电极和分别容纳两个电极的两个电极保持器（202）。 灯管的电极保持器固定在两个灯固定单元的相应的夹紧元件中，因此灯管安装在两个对准的灯固定单元中。 在本背光模块中，灯管可以紧固地固定到夹子元件中，并且也容易地从灯固定单元的夹子元件拆下。
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Patent Agency Ranking
公开(公告)号：US20070171636A1
公开(公告)日：2007-07-26
申请号：US11518795
申请日：2006-09-11
Applicant: Shao-Han Chang , Hua-Dong Zou , Yu-Ya Liu , Li-Zhou Shi
Inventor： Shao-Han Chang , Hua-Dong Zou , Yu-Ya Liu , Li-Zhou Shi
IPC: F21V29/00
CPC classification number: F21V29/83 , F21V19/008 , G02F1/133604
Abstract: A lamp-fixing device includes a base and at least one receiving unit. The receiving unit is formed on the base. The receiving unit includes two opposite protruding walls extending perpendicular out from the base. The two protruding walls and the base cooperatively define a receiving space used to receive one end of a lamp tube with an electrode holder. The two protruding walls and the base each define a heat dissipation hole therein of the receiving space. A backlight module using the lamp-fixing device is also provided. The present lamp-fixing device can help to dissipate heat from lamp tubes fixed thereon efficiently.
Abstract translation: 灯固定装置包括基座和至少一个接收单元。 接收单元形成在基座上。 接收单元包括从基座垂直延伸的两个相对的突出壁。 两个突出的壁和基座协同地限定了用于接收具有电极座的灯管的一端的接收空间。 两个突出的壁和底座分别在容纳空间中限定出一个散热孔。 还提供了使用灯固定装置的背光模块。 本发明的灯固定装置可以有效地从固定在其上的灯管散发热量。
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公开(公告)号：US20070121345A1
公开(公告)日：2007-05-31
申请号：US11502217
申请日：2006-08-10
Applicant: Shao-Han Chang , Li-Zhou Shi , Hua-Dong Zou , Yu-Ya Liu
Inventor： Shao-Han Chang , Li-Zhou Shi , Hua-Dong Zou , Yu-Ya Liu
IPC: F21V7/04
CPC classification number: G02F1/133604 , G02F1/133608
Abstract: A bottom-lighting type backlight module includes a frame, a light guide member and a plurality of linear light sources. The frame includes a base and a plurality of sidewalls extending from the periphery of the base to define an opening. The light guide member is disposed on the opening of the frame, the light guide member having a prism surface away from the base of the frame. The light sources are arranged in the frame under the light guide member. The base of the frame defines a plurality of projections extending out from thereof towards the opening along a direction perpendicular to the light sources, and a plurality of curving surfaces are defined by the base of the frame between two adjacent projections, each curving surface facing the adjacent light source. The present backlight module may have good optical uniformity and high brightness without the help of light diffusion plate.
Abstract translation: 底灯型背光模块包括框架，导光构件和多个线性光源。 框架包括从基部的周边延伸以限定开口的基部和多个侧壁。 导光构件设置在框架的开口上，导光构件具有远离框架的基部的棱镜表面。 光源被布置在光导构件下方的框架中。 框架的底部沿着垂直于光源的方向限定多个从其朝向开口延伸的突起，并且多个弯曲表面由框架的基部限定在两个相邻突起之间，每个弯曲表面面向 相邻光源。 本发明的背光模组可以具有良好的光学均匀性和高亮度，而无需光漫射板的帮助。
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公开(公告)号：US20130274273A1
公开(公告)日：2013-10-17
申请号：US13832240
申请日：2013-03-15
Applicant: Chester A. Metcalf, III , Yu Gui Gu , Spencer D. Kimball , Qingy Li , Blaise S. Lippa , Dominic Ryan , Xinyuan Wu , Dong Zou
Inventor： Chester A. Metcalf, III , Yu Gui Gu , Spencer D. Kimball , Qingy Li , Blaise S. Lippa , Dominic Ryan , Xinyuan Wu , Dong Zou
IPC: C07D473/08
CPC classification number: C07D473/08
Abstract: This disclosure describes a novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.
Abstract translation: 本公开描述了用于抑制TRPA1离子通道和/或与TRPA1相关的医学状况的新型化合物和药物组合物，例如疼痛。
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公开(公告)号：US20120135986A1
公开(公告)日：2012-05-31
申请号：US13357745
申请日：2012-01-25
Applicant: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
Inventor： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC: A61K31/5377 , A61K31/4985 , C07D471/04 , A61K31/437 , A61P35/00 , A61K31/5025 , A61K31/53 , A61K31/519 , C07D473/34 , A61K31/52 , C07D487/04 , A61K31/496
CPC classification number: C07D471/04 , C07D473/34 , C07D487/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US07559686B2
公开(公告)日：2009-07-14
申请号：US11518795
申请日：2006-09-11
Applicant: Shao-Han Chang , Hua-Dong Zou , Yu-Ya Liu , Li-Zhou Shi
Inventor： Shao-Han Chang , Hua-Dong Zou , Yu-Ya Liu , Li-Zhou Shi
CPC classification number: F21V29/83 , F21V19/008 , G02F1/133604
Abstract: A lamp-fixing device includes a base and at least one receiving unit. The receiving unit is formed on the base. The receiving unit includes two opposite protruding walls extending perpendicular out from the base. The two protruding walls and the base cooperatively define a receiving space used to receive one end of a lamp tube with an electrode holder. The two protruding walls and the base each define a heat dissipation hole therein of the receiving space.
Abstract translation: 灯固定装置包括基座和至少一个接收单元。 接收单元形成在基座上。 接收单元包括从基座垂直延伸的两个相对的突出壁。 两个突出的壁和基座协同地限定了用于接收具有电极座的灯管的一端的接收空间。 两个突出的壁和底座分别在容纳空间中限定出一个散热孔。
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