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公开(公告)号：US20160024024A1
公开(公告)日：2016-01-28
申请号：US14774359
申请日：2014-03-13
Applicant: Stephan G. ZECH , Anna KOHLMANN , Feng LI , Yihan WANG , Tianjun ZHOU , David C. DALGARNO , William C. SHAKESPEARE , Xiaotian ZHU , ARIAD PHARMACEUTICALS, INC.
Inventor： Stephan G. Zech , Anna Kohlmann , Feng Li , Yihan Wang , Tianjun Zhou , David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu
IPC: C07D243/08 , C07D401/10 , C07D413/10 , C07D401/14 , C07D403/14 , C07D417/10 , C07D403/10 , C07F9/645 , C07D413/14
CPC classification number: C07D243/08 , A61K31/551 , C07D245/02 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07F9/645
Abstract: This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.
Abstract translation: 本发明涉及通式（I）的化合物：其中可变基团如本文所鉴定，以及化合物的制备和使用。
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公开(公告)号：US08039480B2
公开(公告)日：2011-10-18
申请号：US12277880
申请日：2008-11-25
Applicant: Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
Inventor： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC: A61K31/44 , C07D221/20
CPC classification number: C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
Abstract translation: 本发明涉及抑制巯基蛋白酶的式Ia的取代的碳杂环和杂环螺环化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US08609681B2
公开(公告)日：2013-12-17
申请号：US13248366
申请日：2011-09-29
Applicant: Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
Inventor： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC: A61K31/44 , C07D221/02
CPC classification number: C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
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Patent Agency Ranking
公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
Applicant: Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
Inventor： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC: A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC classification number: C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
Abstract: The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US20120015933A1
公开(公告)日：2012-01-19
申请号：US13248366
申请日：2011-09-29
Applicant: Manfred SCHUDOK , Michael WAGNER , Armin BAUER , Anna KOHLMANN
Inventor： Manfred SCHUDOK , Michael WAGNER , Armin BAUER , Anna KOHLMANN
IPC: A61K31/438 , C07D209/54 , A61K31/403 , C07D471/10 , C07D319/14 , A61K31/357 , C07D491/113 , C07D498/10 , A61K31/5386 , C07C255/31 , A61K31/277 , C07D263/52 , A61K31/423 , A61K31/444 , A61P35/00 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/06 , A61P37/06 , A61P25/14 , A61P11/00 , A61P3/10 , A61P1/00 , A61P25/28 , C07D221/20
CPC classification number: C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
Abstract translation: 本发明涉及抑制巯基蛋白酶的式Ia的取代的碳杂环和杂环螺环化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US08912330B2
公开(公告)日：2014-12-16
申请号：US12998873
申请日：2009-12-11
Applicant: Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
Inventor： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC: C07D471/04 , C07D401/14 , A61K31/437 , A61K31/44 , A61P35/00
CPC classification number: A61K31/44 , C07D471/04
Abstract: This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US20110294806A1
公开(公告)日：2011-12-01
申请号：US12998873
申请日：2009-12-11
Applicant: Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
Inventor： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC: A61K31/437 , A61P35/00 , A61K31/506 , C07D471/04 , A61K31/5377
CPC classification number: A61K31/44 , C07D471/04
Abstract: This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US20090275523A1
公开(公告)日：2009-11-05
申请号：US12277880
申请日：2008-11-25
Applicant: Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
Inventor： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC: A61K38/05 , C07D221/20 , C07D471/10 , C07C255/29 , C07D498/10 , A61P35/00
CPC classification number: C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
Abstract translation: 本发明涉及抑制巯基蛋白酶的式Ia的取代的碳杂环和杂环螺环化合物，其制备方法及其作为药物的用途。
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