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公开(公告)号：US08288351B2
公开(公告)日：2012-10-16
申请号：US12082224
申请日：2008-04-08
Applicant: Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
Inventor： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
IPC: C07K7/18
Abstract: The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
Abstract translation: 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20110118252A1
公开(公告)日：2011-05-19
申请号：US12945575
申请日：2010-11-12
Applicant: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
Inventor： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC: A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC classification number: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090137483A1
公开(公告)日：2009-05-28
申请号：US12082224
申请日：2008-04-08
Applicant: Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
Inventor： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
Abstract: The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
Abstract translation: 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20080312232A1
公开(公告)日：2008-12-18
申请号：US11412302
申请日：2006-04-26
Applicant: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
Inventor： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC: A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC classification number: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090054460A1
公开(公告)日：2009-02-26
申请号：US12008696
申请日：2008-01-11
Applicant: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
Inventor： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC: A61K31/495 , C07D241/04
CPC classification number: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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Patent Agency Ranking
公开(公告)号：US20090048224A1
公开(公告)日：2009-02-19
申请号：US12205616
申请日：2008-09-05
Applicant: Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
Inventor： Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC: A61K31/397 , A61K31/453 , C07D401/02 , C07D405/02 , A61K31/496 , A61K31/4545 , C07D407/02 , A61K31/4025 , A61K31/351 , A61P27/02 , A61P27/06 , A61P11/06 , A61P9/00 , A61P19/02 , A61P25/28 , A61K31/4375 , C07D471/04 , C07D205/04 , A61P3/10 , C07D311/02 , C07D413/02 , A61K31/5377 , A61K31/5415 , C07D279/02 , C07C311/01 , A61K31/18
CPC classification number: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US07414134B2
公开(公告)日：2008-08-19
申请号：US11247050
申请日：2005-10-11
Applicant: Benny C. Askew, Jr. , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
Inventor： Benny C. Askew, Jr. , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
IPC: C07D211/04 , C07D261/08 , C07D249/04 , C07D249/06
CPC classification number: C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
Abstract: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
Abstract translation: 本发明包括新颖的化合物及其药学上可接受的衍生物，用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号：US09187486B2
公开(公告)日：2015-11-17
申请号：US14114481
申请日：2012-04-19
Applicant: Derin C. D'amico , Bradley J. Herberich , Claire L. M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
Inventor： Derin C. D'amico , Bradley J. Herberich , Claire L. M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: The invention relates to bicyclic compounds of formulas I and I′, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Abstract translation: 本发明涉及式I和I'的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US20140221344A1
公开(公告)日：2014-08-07
申请号：US14114481
申请日：2012-04-19
Applicant: Derin C. D'amico , Bradley J. Herberich , Claire L.M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
Inventor： Derin C. D'amico , Bradley J. Herberich , Claire L.M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: The invention relates to bicyclic compounds of formulas I and I′, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Abstract translation: 本发明涉及式I和I'的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US08168592B2
公开(公告)日：2012-05-01
申请号：US11584177
申请日：2006-10-19
Applicant: Colin V. Gegg, Jr. , Eileen J. Johnson , Leslie P. Miranda , Kenneth W. Walker , Jerry Ryan Holder , Marie E. Wright , Derin C. D'Amico
Inventor： Colin V. Gegg, Jr. , Eileen J. Johnson , Leslie P. Miranda , Kenneth W. Walker , Jerry Ryan Holder , Marie E. Wright , Derin C. D'Amico
CPC classification number: A61K38/225 , C07K14/57527
Abstract: Disclosed is a composition of matter that involves a CGRP peptide antagonist. A pharmaceutical composition is disclosed that comprises the composition of matter and a pharmaceutically acceptable carrier, which can be configured for administration to a patient. Also disclosed is a method of producing the composition of matter. Methods of treating, preventing or mitigating migraine, are also disclosed.
Abstract translation: 公开了涉及CGRP肽拮抗剂的物质组合物。 公开了包含物质组合物和药学上可接受的载体的药物组合物，其可被配置用于给予患者。 还公开了一种生产物质组合物的方法。 还公开了治疗，预防或减轻偏头痛的方法。
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