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    A2B adenosine receptor antagonists
    9.
    发明授权
    A2B adenosine receptor antagonists 失效
    A2B腺苷受体拮抗剂

    公开(公告)号：US07238700B2

    公开(公告)日：2007-07-03

    申请号：US10837290

    申请日：2004-04-30

    申请人： Venkata Palle ,  Vaibhav Varkhedkar ,  Jeff Zablocki ,  Dengming Xiao

    发明人： Venkata Palle ,  Vaibhav Varkhedkar ,  Jeff Zablocki ,  Dengming Xiao

    IPC分类号： C07D473/16 ,  C07D473/24 ,  C07D473/18 ,  A61K31/52 ,  A61K31/522

    CPC分类号： C07D473/16

    摘要： Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is optionally substituted alkyl or a group —Y-Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; and X is oxygen, sulfur, or NH—, or a pharmaceutically acceptable salt, ester, or prodrug thereof. The compounds are particularly useful for treating asthma and diabetic retinopathy.

    摘要翻译： 公开了式I的新型A 2 B 2 N腺苷受体拮抗剂：下式化合物：其中：R 1是任选取代的烷基或基团-YZ，其中Y是 共价键或任选取代的亚烷基，Z为任选取代的环烷基，任选取代的芳基，任选取代的杂芳基，任选取代的杂环基，任选取代的烯基或任选取代的炔基，条件是当Y为共价键时，Z不能为烯基或 炔基; 并且X是氧，硫或NH-，或其药学上可接受的盐，酯或前药。 该化合物特别可用于治疗哮喘和糖尿病性视网膜病变。