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    Stable lipid-comprising drug delivery complexes and methods for their production
    1.
    发明授权
    Stable lipid-comprising drug delivery complexes and methods for their production 失效
    稳定的含脂质药物递送复合物及其生产方法

    公开(公告)号：US06008202A

    公开(公告)日：1999-12-28

    申请号：US939874

    申请日：1997-09-29

    申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi ,  Ralph Wilfred Paul ,  David L. Sloane ,  Aaron Garth Loomis

    发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi ,  Ralph Wilfred Paul ,  David L. Sloane ,  Aaron Garth Loomis

    IPC分类号： A61K9/127 ,  C12N15/88 ,  A61K31/00 ,  A61K48/00

    CPC分类号： C12N15/88 ,  A61K9/1272

    摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

    摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。