公开(公告)号：US09227082B2

公开(公告)日：2016-01-05

申请号：US12550799

申请日：2009-08-31

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61N5/06 ,  A61B18/20 ,  A61K41/00 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/18

CPC classification number: A61N5/0616 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0617 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0642 ,  A61N2005/0644 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/0662

Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 m W. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

Abstract translation: 公开了一种用于治疗皮肤疾病的系统和方法。 更具体地，所公开的发明涉及使用低强度光疗法减少痤疮和痤疮相关细菌。 在说明性实施例中，含有痤疮细菌的皮肤用来自发光二极管的一系列光脉冲进行处理。 LED具有约660nm的主要发射波长和约4mW的能量输出。含有痤疮细菌的组织暴露于来自光源的脉冲约100次，每脉冲约250毫秒，脉冲间隔为 约100毫秒。

公开(公告)号：US09144690B2

公开(公告)日：2015-09-29

申请号：US12550464

申请日：2009-08-31

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61N5/06

CPC classification number: A61N5/0616 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/0663 ,  A61N2005/0667

Abstract: A method including photomodulating mammalian tissue with more than one light source of narrowband, multi chromatic electromagnetic radiation, wherein at least one light source emits radiation at a wavelength corresponding to yellow light and at least one light source emits radiation corresponding to infra-red light, wherein the ratio of the intensity of yellow light to infra-red light is about 4:1.

Abstract translation: 一种方法，包括用多于一个窄带多色电磁辐射光源对哺乳动物组织进行光调制，其中至少一个光源发射对应于黄光的波长的辐射，并且至少一个光源发射对应于红外光的辐射， 其中黄光强度与红外光的比值约为4:1。

公开(公告)号：US09017391B2

公开(公告)日：2015-04-28

申请号：US12583578

申请日：2009-08-21

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61N5/06 ,  A61K41/00 ,  A61B18/20 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/18

CPC classification number: A61N5/0616 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0617 ,  A61N5/062 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/067

Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.

Abstract translation: 公开了一种用于治疗皮肤疾病的系统和方法。 更具体地，所公开的发明涉及使用多种光源来处理或不使用局部组合物或光调制增强剂的皮肤。 例如，双重发光二极管可以以相对低的功率（小于约10J / cm 2）使用以对皮肤或活组织进行光调制，以减少皱纹，细纹，痤疮，痤疮细菌和其它皮肤病症。

公开(公告)号：US20100081185A1

公开(公告)日：2010-04-01

申请号：US12583562

申请日：2009-08-21

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: C12N13/00

CPC classification number: C12N13/00 ,  A61N5/0616 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662

Abstract: The invention can be characterized as method for stimulating or inhibiting gene expression by photomodulating living cells using a source of narrowband multichromatic electromagnetic radiation. The cells may include, among others, nerve cells, skin cells, retinal cells, heart cells, stem cells, brain cells, cells found in human organs, cells found in hair follicles, and cells found in the human eye or retina. Photomodulation may be enhanced using topically or orally administered compositions. The source of narrowband multichromatic electromagnetic radiation may include at least one light emitting diode (LED) that can emit radiation having a wavelength of from about 300 nm to about 1600 nm.

Abstract translation: 本发明可以被表征为通过使用窄带多层电磁辐射源对活细胞进行光调制来刺激或抑制基因表达的方法。 细胞可以包括神经细胞，皮肤细胞，视网膜细胞，心脏细胞，干细胞，脑细胞，人器官中发现的细胞，毛囊中发现的细胞，以及在人眼或视网膜中发现的细胞。 使用局部或口服给药的组合物可以增强光调节。 窄带多层电磁辐射的来源可以包括至少一个能够发射波长为约300nm至约1600nm的辐射的发光二极管（LED）。

公开(公告)号：US20090317911A1

公开(公告)日：2009-12-24

申请号：US12549976

申请日：2009-08-28

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: C12N15/01

CPC classification number: A61N5/0616 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0652 ,  A61N2005/0663

Abstract: A method for stimulating, inhibiting, or regulating gene expression including exposing a living cell with at least one gene to an administered source of narrowband, multichromatic electromagnetic radiation.

Abstract translation: 用于刺激，抑制或调节基因表达的方法，包括将具有至少一个基因的活细胞暴露于施用的窄带多色电磁辐射源。

公开(公告)号：US07004933B2

公开(公告)日：2006-02-28

申请号：US09876157

申请日：2001-06-08

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61M31/00

CPC classification number: A61M31/002 ,  A61B2017/00765 ,  A61M37/0092 ,  A61M2037/0007

Abstract: A system for enhancing and improving the transcutaneous or transdermal delivery of topical chemicals or drugs. A disposable container contains a substantially sterile unit dose of an active agent adapted for a single use in a medical treatment. The unit dose is formulated to enhance transport of the active agent through mammalian skin when the active agent is applied to the skin and the skin is exposed to light and/or ultrasound defined by at least one specific parameter.

公开(公告)号：US06398753B2

公开(公告)日：2002-06-04

申请号：US09168683

申请日：1998-10-09

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61B1720

CPC classification number: A61M31/002 ,  A61M37/0092 ,  A61M2037/0007

Abstract: A system for enhancing and improving the transcutaneous or transdermal delivery of topical chemicals or drugs. A disposable container contains a substantially sterile unit dose of an active agent adapted for a single use in a medical treatment. The unit dose is formulated to enhance transport of the active agent through mammalian skin when the active agent is applied to the skin and the skin is exposed to light and/or ultrasound defined by at least one specific parameter.

公开(公告)号：US06283956B1

公开(公告)日：2001-09-04

申请号：US09203178

申请日：1998-11-30

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61B1818

CPC classification number: A61N5/0617 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61N5/062 ,  A61N2005/0652

Abstract: A system for producing preferential damage to hair exiting mammalian skin. A agent having an average diameter for enabling the agent to penetrate the hair duct is selected. The agent is designed to attach to, or become physically incorporated into, the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent has an electromagnetic radiation absorption characteristic which enables the agent to absorb a first wavelength of electromagnetic radiation from a skin-penetrating electromagnetic radiation source, such as a laser. The agent is applied to the skin so that the agent penetrates the skin and attaches to or becomes physically incorporated into the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent is exposed to the first wavelength of electromagnetic radiation and absorbs the first wavelength of electromagnetic radiation.

Abstract translation: 用于对离开哺乳动物皮肤的毛发产生优先损伤的系统。 选择具有使试剂穿过发道的平均直径的试剂。 该药剂被设计成附着到头发，头发毛囊，毛发或头发管道上，或者将它们物理地并入到头发，毛发，头发灯泡或发道中。 该试剂具有电磁辐射吸收特性，其使得试剂能够从诸如激光的皮肤穿透电磁辐射源吸收第一波长的电磁辐射。 将药剂施用于皮肤，使得药剂渗透皮肤并附着或变成物理地并入毛发，毛囊，毛发或毛发管道中。 该试剂暴露于第一波长的电磁辐射并吸收第一波长的电磁辐射。

公开(公告)号：US09192780B2

公开(公告)日：2015-11-24

申请号：US11346622

申请日：2006-02-03

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61B19/00 ,  A61N5/06 ,  A61N5/067

CPC classification number: A61N5/0616 ,  A61N5/0601 ,  A61N5/0613 ,  A61N2005/0605 ,  A61N2005/0609 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0654 ,  A61N2005/0662 ,  A61N2005/067

Abstract: Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.

Abstract translation: 公开了用于治疗细胞，特别是视觉途径障碍的系统和方法。 更具体地，所公开的发明涉及视网膜上皮细胞的光调节和/或光老化，以治疗各种视力障碍。 治疗视网膜细胞以减少或逆转视觉途径障碍的作用的过程使用应用于视网膜细胞的窄带光源来提供非常低的能量注量。

公开(公告)号：US20110159121A1

公开(公告)日：2011-06-30

申请号：US12976741

申请日：2010-12-22

Applicant: David H. McDaniel

Inventor： David H. McDaniel

IPC: A61K36/889 ,  C12Q1/68 ,  C12Q1/02 ,  C12N5/00 ,  A61P39/00 ,  A61P35/00 ,  A61K36/45 ,  A61K36/13 ,  A61K36/87 ,  A61K36/63 ,  A61K36/73 ,  A61K36/82

CPC classification number: G01N33/5023 ,  A23L2/52 ,  A23L33/105 ,  A61K8/97 ,  A61K36/14 ,  A61K36/45 ,  A61K36/51 ,  A61K36/63 ,  A61K36/87 ,  A61K36/889 ,  A61Q19/00 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N2333/195 ,  G01N2333/37 ,  G01N2333/405 ,  G01N2333/415 ,  G01N2500/00

Abstract: Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.

Abstract translation: 本文提供了在体外培养细胞的方法，以利用细胞的生物化学生产能力来制备由于其生物学效应而被评估和收获的代谢物。 还提供了用于评估来自这种培养细胞的提取物以表征其生物活性的系统，特别是在对健康，健康，长寿，DNA维持，线粒体健康和/或生物发生等方面的影响方面。 还提供了生物活性提取物，其组分，以及包含这些物质的组合物（如化妆品或药物制剂）。