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    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat
    5.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat 有权
    用于医疗装置的亲水性润滑性涂层包括疏水性面漆

    公开(公告)号：US06589215B2

    公开(公告)日：2003-07-08

    申请号：US09728589

    申请日：2000-12-01

    申请人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    发明人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    IPC分类号： A61M2500

    CPC分类号： A61L29/145 ,  A61L29/085 ,  A61L29/12 ,  C08L83/04 ,  C08L71/02 ,  A61L29/049

    摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.

    摘要翻译： 本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。 第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。 疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。

    Lubricated sleeve material for stent delivery
    6.
    发明授权
    Lubricated sleeve material for stent delivery 有权
    用于支架输送的润滑套管材料

    公开(公告)号：US06221097B1

    公开(公告)日：2001-04-24

    申请号：US09273520

    申请日：1999-03-22

    申请人： Lixiao Wang ,  Dachuan Yang ,  Jianhua Chen ,  The Thomas Trinh Tran

    发明人： Lixiao Wang ,  Dachuan Yang ,  Jianhua Chen ,  The Thomas Trinh Tran

    IPC分类号： A61F202

    CPC分类号： A61F2/958 ,  A61F2/95 ,  A61F2002/9586

    摘要： The present invention relates to a stent delivery system in which a catheter carries on its distal end portion a stent which is held in place around the catheter prior to and during percutaneous delivery by means of one, and preferably two, end sleeves. The sleeves are positioned around the catheter with one end portion of each sleeve associated thereto. The other end of each sleeve overlaps an end portion of the stent to hold it in place on the catheter in a contracted condition. The present invention provides an improvement with respect to lubrication of the sleeve prior to its assembly with the catheter. A preferred way of lubricating the sleeve is by incorporating a lubricant additive within the sleeve composition.

    摘要翻译： 支架输送系统技术领域本发明涉及一种支架输送系统，其中导管在其远端部分承载支架，该支架通过一个，优选两个端部套筒在经皮输送之前和之后被保持在导管周围的适当位置。 袖子围绕导管定位，每个套筒的一个端部与其相关联。 每个套筒的另一端与支架的端部重叠，以在收缩状态下将其保持在导管上的适当位置。 本发明提供了在与导管组装之前套筒的润滑方面的改进。 润滑套筒的优选方式是通过在套筒组合物中引入润滑剂添加剂。

    Polymerization of pyrrole and its derivatives
    8.
    发明授权
    Polymerization of pyrrole and its derivatives 失效
    吡咯及其衍生物的聚合

    公开(公告)号：US5120807A

    公开(公告)日：1992-06-09

    申请号：US645072

    申请日：1991-01-18

    申请人： Yen Wei ,  Dachuan Yang ,  Jing Tian

    发明人： Yen Wei ,  Dachuan Yang ,  Jing Tian

    IPC分类号： C08F2/00 ,  C08F2/46 ,  C08F34/00

    CPC分类号： C08F34/00

    摘要： Electrically conductive polypyrrole and its derivatives are prepared by polymerizing compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, halogen, R.sup.4, --OR.sup.4 or --SR.sup.4 ; and R.sup.4 is aryl of 4 to 12 carbons or aliphatic of 1 to 20 carbons; comprising reacting the compound of formula I in the presence of an initiator, the initiator comprising a 2-substituted pyrrole nucleus which has a lower oxidation potential than the compound of formula I and which is capable of being incorporated into the polymer resulting from the polymerization reaction; a chemical oxidant or an applied electrochemical potential; and a solvent.

    摘要翻译： 导电聚吡咯及其衍生物通过聚合下式的化合物制备：其中R 1，R 2和R 3独立地是氢，卤素，R 4，-OR 4或-SR 4; R4为碳数4〜12的芳基或碳原子数为1〜20的脂肪族， 包括在引发剂的存在下使式I化合物反应，该引发剂包含具有比式I化合物更低的氧化电位的2-取代的吡咯核，其能够被引入由聚合反应产生的聚合物中 ; 化学氧化剂或施加的电化学电位; 和溶剂。

    Dual surface protection coating for drug delivery balloon catheters and stents
    9.
    发明授权
    Dual surface protection coating for drug delivery balloon catheters and stents 失效
    用于药物输送气囊导管和支架的双表面保护涂层

    公开(公告)号：US06656156B2

    公开(公告)日：2003-12-02

    申请号：US10154186

    申请日：2002-05-22

    申请人： Dachuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    发明人： Dachuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    IPC分类号： A61M2900

    CPC分类号： A61L31/16 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： The invention relates to a medical device, such as a stent or a balloon catheter that includes an expandable body portion which has an exterior surface that contacts a vessel wall during treatment. The medical device includes a first coating disposed over at least a portion of the exterior surface. The first coating includes a therapeutic substance that is intended for controlled release from the exterior surface. The medical device further includes a second coating overlaying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the therapeutic substance therethrough when the body portion is inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to allow elution of the therapeutic substance through fissures formed in the second coating.

    摘要翻译： 本发明涉及医疗装置，例如支架或气囊导管，其包括在治疗期间具有与血管壁接触的外表面的可扩张体部分。 医疗装置包括设置在外表面的至少一部分上的第一涂层。 第一涂层包括旨在从外表面控制释放的治疗物质。 医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。 第二涂层包括当主体部分插入血管内腔时通常不能透过治疗物质洗脱的材料。 第二涂层的材料相对无弹性，使得第二涂层在体部膨胀期间断裂，以允许通过在第二涂层中形成的裂缝洗脱治疗物质。

    Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
    10.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising a hybrid top coat 有权
    用于医疗装置的亲水性润滑性涂层，包括混合面漆

    公开(公告)号：US06610035B2

    公开(公告)日：2003-08-26

    申请号：US09822973

    申请日：2001-03-30

    申请人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    发明人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    IPC分类号： A61M2500

    CPC分类号： A61L29/145 ,  A61L29/085 ,  A61L29/12 ,  C08L83/04

    摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.

    摘要翻译： 本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。 第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。 疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。