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    Method of diagnosing preeclampsia or pregnancy-induced hypertension
    4.
    发明授权
    Method of diagnosing preeclampsia or pregnancy-induced hypertension 有权

    公开(公告)号：US11045527B2

    公开(公告)日：2021-06-29

    申请号：US15889917

    申请日：2018-02-06

    Applicant: Curemark, LLC

    Inventor： Joan Fallon

    IPC: A61K38/48 ,  A61K38/54 ,  A61K36/185 ,  A61K38/47 ,  A61K38/46

    Abstract: A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or by other methods. Further, a method of using the presence of chymotrypsin in the maternal GI tract as a biomarker, to determine the likelihood of developing preeclampsia, a pregnancy induced hypertension, and eclampsia/toxemia is disclosed.

    USE OF LACTULOSE IN THE TREATMENT OF AUTISM
    5.
    发明申请
    USE OF LACTULOSE IN THE TREATMENT OF AUTISM 审中-公开

    公开(公告)号：US20190275066A1

    公开(公告)日：2019-09-12

    申请号：US16422079

    申请日：2019-05-24

    Applicant: Curemark, LLC

    Inventor： Joan M. Fallon ,  Richard Feltenstein

    IPC: A61K31/7016 ,  A61K31/047 ,  A61K31/045 ,  A61K31/7012

    Abstract: A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

    Use of lactulose in the treatment of autism
    6.
    发明授权
    Use of lactulose in the treatment of autism 有权
    使用乳果糖治疗自闭症

    公开(公告)号：US09345721B2

    公开(公告)日：2016-05-24

    申请号：US14087930

    申请日：2013-11-22

    Applicant: Curemark LLC

    Inventor： Joan M. Fallon ,  Richard Feltenstein

    IPC: A61K31/7016 ,  A61K35/37 ,  A61K31/045 ,  A61K31/7012

    CPC classification number: A61K31/7016 ,  A61K31/045 ,  A61K31/047 ,  A61K31/7012

    Abstract: A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

    Abstract translation: 一种治疗自闭症，其中施用有效量的乳果糖以便结合胃肠道，血液和神经系统中的过量氨，以防止或逆转由施用某些抗生素引起的氨中毒。 结肠中的乳果糖分子被某些细菌发酵。 发酵过程降低了结肠pH，细菌形成氨离子的氨被氨基酸和蛋白质合成使用。 这降低了血清氨水平，降低了神经毒性。

    METHODS AND COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS OF PRION DISEASES
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS OF PRION DISEASES 有权
    治疗重症疾病症状的方法和组合

    公开(公告)号：US20150273030A1

    公开(公告)日：2015-10-01

    申请号：US14713178

    申请日：2015-05-15

    Applicant: Curemark, LLC

    Inventor： Joan M. Fallon

    IPC: A61K38/54 ,  C12Q1/37

    CPC classification number: A61K38/54 ,  A61K36/185 ,  A61K38/465 ,  A61K38/47 ,  A61K38/4826 ,  A61K38/4873 ,  C12Q1/37 ,  C12Y301/01 ,  C12Y302/01 ,  C12Y304/00 ,  C12Y304/21001 ,  C12Y304/21004 ,  C12Y304/22002 ,  G01N33/6896 ,  G01N2333/976 ,  G01N2800/2828 ,  G01N2800/52 ,  A61K2300/00

    Abstract: A therapeutic composition for the treatment of the symptoms of prion diseases and the method for preparing the therapeutic agents is disclosed. The therapeutic composition is a stable pharmaceutical composition comprising one or more digestive and/or pancreatic enzymes. The therapeutic composition may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic composition may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using fecal chymotrypsin level as a biomarker for the presence of a prion disease, or the likelihood of an individual to develop a prion disease is disclosed.

    Abstract translation: 公开了治疗朊病毒疾病症状的治疗组合物和治疗剂的制备方法。 治疗组合物是包含一种或多种消化和/或胰酶的稳定的药物组合物。 治疗组合物可以通过各种封装技术制造。 治疗组合物的递送可以通过注射，通过粘附药物贴剂或其它方法口服制备。 此外，公开了使用粪便胰凝乳蛋白酶水平作为朊病毒疾病存在的生物标志物的方法或个体发展朊病毒病的可能性。

    Methods of treating celiac disease
    10.
    发明授权
    Methods of treating celiac disease 有权

    公开(公告)号：US11364287B2

    公开(公告)日：2022-06-21

    申请号：US16422462

    申请日：2019-05-24

    Applicant: Curemark, LLC

    Inventor： Joan M. Fallon ,  Matthew F. Heil ,  James Szigethy ,  James J. Fallon

    IPC: A61K38/54 ,  A61K38/46 ,  A61K38/47 ,  A61K38/48

    Abstract: Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of Celiac Disease. Also described herein is a method for treating a subject with Celiac Disease using digestive enzymes and their derivatives to alleviate the symptoms of Celiac Disease. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally or recombinantly derived, or their derivatives, in an amount effective to reduce one or more symptoms of Celiac Disease.

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