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公开(公告)号：US20180051028A1
公开(公告)日：2018-02-22
申请号：US15557197
申请日：2016-03-07
申请人： JONGWON LIM , MICHAEL D. ALTMAN , JASON D. BRUBAKER , CRAIG R. GIBEAU , MERCK SHARP & DOHME CORP.
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K31/551 , C07D519/00 , A61K31/55 , A61K31/553
CPC分类号： C07D487/04 , A61K31/519 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , A61P29/00 , C07D519/00
摘要： The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US07884107B2
公开(公告)日：2011-02-08
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
发明人： Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
IPC分类号： A61K31/54 , C07D413/00 , C07D403/00 , C07D405/00
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明公开了作为HDM2蛋白的制备方法的抑制剂的新型化合物，包括一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2蛋白相关的一种或多种疾病的方法 或P53使用这些化合物或药物组合物。
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公开(公告)号：US10040798B2
公开(公告)日：2018-08-07
申请号：US15557201
申请日：2016-03-07
申请人： MERCK SHARP & DOHME CORP. , Jongwon Lim , Michael D. Altman , Jason D. Brubaker , Craig R. Gibeau
IPC分类号： C07D487/04 , A61K45/06 , A61K31/55 , C07D519/00 , A61K31/551 , A61K31/5025
摘要： The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US08859776B2
公开(公告)日：2014-10-14
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号： C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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5.发明申请公开(公告)号：US20120208844A1
公开(公告)日：2012-08-16
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
IPC分类号： A61K31/4545 , A61P35/02 , A61P35/00 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式（1）化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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公开(公告)号：US10329294B2
公开(公告)日：2019-06-25
申请号：US15557197
申请日：2016-03-07
申请人： MERCK SHARP & DOHME CORP. , Jongwon Lim , Michael D. Altman , Jason D. Brubaker , Craig R. Gibeau
IPC分类号： A61K31/519 , C07D487/04 , A61K31/4162 , C07D519/00 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , A61P29/00
摘要： The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US09932350B2
公开(公告)日：2018-04-03
申请号：US15515377
申请日：2015-09-25
申请人： MERCK SHARP & DOHME CORP. , Craig R. Gibeau , Solomon D. Kattar , Charles A. Lesburg , Jongwon Lim , John K. F. Maclean , Umar F. Mansoor , Alan B. Northrup , John M. Sanders , Graham F. Smith
发明人： Michael D. Altman , Jason D. Brubaker , Matthew L. Childers , Anthony Donofrio , Thierry Fischmann , Craig R. Gibeau , Solomon D. Kattar , Charles A. Lesburg , Jongwon Lim , John K. F. Maclean , Umar F. Mansoor , Alan B. Northrup , John M. Sanders , Graham F. Smith
IPC分类号： C07D491/08 , C07D239/94 , A61K31/517 , A61K45/06 , C07D239/88 , A61K31/5377 , C07D403/12 , C07D401/12 , C07D413/12 , A61K31/538 , C07D491/052 , A61K31/5386 , C07D491/048 , A61K31/55 , C07D405/12
CPC分类号： C07D491/08 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/55 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D491/048 , C07D491/052 , C07D498/08 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051035A1
公开(公告)日：2018-02-22
申请号：US15557206
申请日：2016-03-07
发明人： JONGWON LIM , MICHAEL D. ALTMAN , CRAIG R. GIBEAU
IPC分类号： C07D495/04 , A61K31/4985 , A61K45/06 , A61K31/551 , C07D519/00 , A61K31/55
CPC分类号： C07D495/04 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/55 , A61K31/551 , A61K45/06 , A61P29/00 , C07D519/00 , A61K2300/00
摘要： The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051030A1
公开(公告)日：2018-02-22
申请号：US15557203
申请日：2016-03-07
IPC分类号： C07D487/04 , C07D403/14 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , A61P29/00 , C07D403/14 , A61K2300/00
摘要： The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051027A1
公开(公告)日：2018-02-22
申请号：US15557195
申请日：2016-03-07
申请人： JONGWON LIM , MICHAEL D. ALTMAN , MATTHEW L. CHILDERS , CRAIG R. GIBEAU , GINNY DAI HO , HONCHUNG TSUI , MERCK SHARP & DOHME CORP.
发明人： JONGWON LIM , MICHAEL D. ALTMAN , MATTHEW L. CHILDERS , CRAIG R. GIBEAU , GINNY DAI HO , HONCHUNG TSUI
IPC分类号： C07D487/04 , A61K45/06 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D495/04 , A61K31/4985 , A61K31/53
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/635 , A61K45/06 , C07D495/04
摘要： The present invention relates to carboxamide inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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