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    Sterile gel compositions for wound treatment
    1.
    发明授权
    Sterile gel compositions for wound treatment 失效
    用于伤口治疗的无菌凝胶组合物

    公开(公告)号：US5693624A

    公开(公告)日：1997-12-02

    申请号：US462243

    申请日：1995-06-05

    Applicant: Craig J. Hardy ,  Charlotte Maria Findlay

    Inventor： Craig J. Hardy ,  Charlotte Maria Findlay

    IPC: A61K9/107 ,  A61F13/00 ,  A61K9/70 ,  A61L2/07 ,  A61L15/28 ,  A61L15/44 ,  A61L26/00 ,  A61K31/715

    CPC classification number: A61L26/008 ,  A61L15/28 ,  A61L2/07 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/0071 ,  A61L2300/602 ,  Y10S514/944

    Abstract: The invention provides aqueous gel compositions for use as wound dressings and comprising from 2% to 10% w/v of alginate and from 25% to 40% w/v of polyhydric alcohol, said compositions being substantially sterile. The alginate is preferably sodium alginate and/or potassium alginate. the polyhydric alcohol is preferably propylene glycol or hexylene glycol. Also provided is a process of making such gel compositions comprising the steps of: providing an aqueous gel having the above composition and sterilizing the aqueous gel. Preferably, the aqueous gel is sterilized by heating.

    Abstract translation: 本发明提供用作伤口敷料的含水凝胶组合物，其包含2％至10％w / v的藻酸盐和25％至40％w / v的多元醇，所述组合物基本上是无菌的。 藻酸盐优选为藻酸钠和/或藻酸钾。 多元醇优选为丙二醇或己二醇。 还提供了制备这种凝胶组合物的方法，其包括以下步骤：提供具有上述组成的水性凝胶并对含水凝胶灭菌。 优选地，水凝胶通过加热灭菌。

    Swellable wound dressing materials
    4.
    发明授权
    Swellable wound dressing materials 失效
    可膨胀伤口敷料

    公开(公告)号：US6022556A

    公开(公告)日：2000-02-08

    申请号：US201522

    申请日：1994-02-25

    Applicant: Craig J. Hardy

    Inventor： Craig J. Hardy

    IPC: A61L15/44 ,  A61K31/00 ,  A61K31/715 ,  A61L15/28 ,  A61L26/00 ,  A61P17/00 ,  A61K9/70

    CPC classification number: A61L15/28 ,  A61L26/0023

    Abstract: The invention provides water swellable wound dressing materials comprising from 5% to 50% of an alginate ester of a C.sub.1 -C.sub.6 polyhydric alcohol; from 50% to 95% of a humectant consisting of one or more C.sub.1 -C.sub.6 monohydric or polyhydric alcohols; and from 0% to 30% of water, the percentages being calculated by weight based on the weight of the material when anhydrous. The preferred alginate ester is propylene glycol alginate (PGA). The materials swell but do not dissolve in cold or warm water. Insolubility is achieved by the addition of polyvaent cations such as calcium ions, or by covalent cross-linking of the pga, or by adding from 10 to 35% by weight of water-swellable polysaccharide such as gelatin, or by adding from 5% to 20% by weight of a cationic polymer such as chitosan.

    Abstract translation: 本发明提供包含5％至50％的C1-C6多元醇藻酸酯的水溶胀性伤口敷料材料; 50％至95％的由一种或多种C1-C6一元醇或多元醇组成的保湿剂; 和0％至30％的水，所述百分比基于当无水时基于材料的重量的重量计算。 优选的藻酸盐是丙二醇藻酸盐（PGA）。 材料膨胀但不溶于冷水或温水。 通过添加聚离子阳离子如钙离子或通过pga的共价交联或通过加入10至35重量％的水溶胀性多糖如明胶来实现不溶性，或通过加入5％至 20重量％的阳离子聚合物如壳聚糖。

    Water soluble wound dressing materials
    5.
    发明授权
    Water soluble wound dressing materials 失效
    水溶性伤口敷料

    公开(公告)号：US5735812A

    公开(公告)日：1998-04-07

    申请号：US204024

    申请日：1994-02-28

    Applicant: Craig J. Hardy

    Inventor： Craig J. Hardy

    IPC: A61L15/44 ,  A61L15/28 ,  A61L26/00 ,  A61F13/00

    CPC classification number: A61L26/0023 ,  A61L15/28

    Abstract: The invention provides water soluble wound dressing materials comprising from 5% to 50% of an alginate ester of a C.sub.1 -C.sub.6 polyhydric alcohol; from 50% to 95% of a humectant consisting of one or more C.sub.1 -C.sub.6 monohydric or polyhydric alcohols; and from 0% to 30% of water, the percentages being calculated by weight based on the weight of the material when anhydrous. The preferred alginate ester is propylene glycol alginate (PGA). The materials dissolve in water at temperatures below 40.degree. C. The materials are normally produced in the form of soft, conformable, wound-friendly films. The materials may also comprise medicaments or antiseptics.

    Abstract translation: 本发明提供了包含5％至50％的C1-C6多元醇的藻酸盐的水溶性伤口敷料材料; 50％至95％的由一种或多种C1-C6一元醇或多元醇组成的保湿剂; 和0％至30％的水，所述百分比基于当无水时基于材料的重量的重量计算。 优选的藻酸盐是丙二醇藻酸盐（PGA）。 这些材料在低于40℃的温度下溶解在水中。这些材料通常以柔软的，顺应性的伤口薄膜的形式生产。 这些材料还可以包含药物或防腐剂。

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