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    ULTRASOUND GUIDED OPENING OF BLOOD-BRAIN BARRIER
    2.
    发明申请
    ULTRASOUND GUIDED OPENING OF BLOOD-BRAIN BARRIER 有权

    公开(公告)号：US20230128189A1

    公开(公告)日：2023-04-27

    申请号：US18146028

    申请日：2022-12-23

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar Ramamurthy

    IPC: A61N7/00 ,  A61B8/06 ,  A61B8/14 ,  A61B8/00 ,  A61B8/08 ,  A61N7/02 ,  A61B9/00

    Abstract: An ultrasound treatment system operable to deliver ultrasound energy to a patient's brain, the system comprises a treatment ultrasound transducer comprising a plurality of treatment elements, the treatment ultrasound transducer locatable to deliver ultrasound into the head of the patient. The system further comprises a data store, one or more position sensors configured to detect relative movement between the head of the patient and the treatment ultrasound transducer, and a data processor.

    ULTRASOUND TRANSDUCER ASSEMBLY
    3.
    发明申请
    ULTRASOUND TRANSDUCER ASSEMBLY 有权

    公开(公告)号：US20230082109A1

    公开(公告)日：2023-03-16

    申请号：US17874166

    申请日：2022-07-26

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar S. Ramamurthy ,  Daniel E. Need ,  John D. Marshall ,  Jonathan B. Hofius ,  Mallika S. Keralapura

    IPC: A61B8/00 ,  A61B8/08

    Abstract: An ultrasound transducer assembly is connectable to an ultrasound system and comprises one or more ultrasound transducer elements supported by a cap. The ultrasound transducer elements are operable to direct ultrasound energy toward brain tissue of a subject and/or to receive echo ultrasound energy when the ultrasound transducer assembly is mounted on the head of the subject. Some embodiments include a fillable jacket coupled to the inner surface of the cap and in acoustic contact with the one or more transducer elements.

    SYSTEMS AND METHODS FOR ULTRASOUND REVIEW AND IMAGING
    4.
    发明申请
    SYSTEMS AND METHODS FOR ULTRASOUND REVIEW AND IMAGING 审中-公开

    公开(公告)号：US20190183457A1

    公开(公告)日：2019-06-20

    申请号：US16324542

    申请日：2017-08-16

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar Ramamurthy

    IPC: A61B8/14 ,  G01S7/52 ,  G01S7/00 ,  G16H30/40

    CPC classification number: A61B8/14 ,  A61B8/00 ,  A61B8/5207 ,  G01S7/003 ,  G01S7/52098 ,  G16H30/40

    Abstract: A system for reviewing results of ultrasound examinations provides enhanced control over reviewed images. A review and imaging system receives additional data comprising one or more of additional ultrasound images generated using parameter settings different from those selected by and sonographer and earlier stage ultrasound data. An ultrasound machine may be configured to acquire and make the additional data available to the review and imaging system. The review and imaging system may provide a wide range of control options for obtaining optimized display of images based on the additional data.

    Methods and systems for confirming focus of ultrasound beams
    5.
    发明授权
    Methods and systems for confirming focus of ultrasound beams 有权

    公开(公告)号：US12017093B2

    公开(公告)日：2024-06-25

    申请号：US18358295

    申请日：2023-07-25

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar S. Ramamurthy ,  Mallika Keralapura ,  John Douglas Marshall

    IPC: A61N7/00

    CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

    Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,vi.

    Ultrasound guided opening of blood-brain barrier
    6.
    发明授权
    Ultrasound guided opening of blood-brain barrier 有权

    公开(公告)号：US11534630B2

    公开(公告)日：2022-12-27

    申请号：US16322437

    申请日：2017-07-31

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar Ramamurthy

    IPC: A61N7/00 ,  A61B8/06 ,  A61B8/14 ,  A61B8/00 ,  A61B8/08 ,  A61N7/02 ,  A61B9/00

    Abstract: A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier. Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

    METHODS AND SYSTEMS FOR CONFIRMING FOCUS OF ULTRASOUND BEAMS
    8.
    发明公开
    METHODS AND SYSTEMS FOR CONFIRMING FOCUS OF ULTRASOUND BEAMS 审中-公开

    公开(公告)号：US20240307709A1

    公开(公告)日：2024-09-19

    申请号：US18671236

    申请日：2024-05-22

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar S. RAMAMURTHY ,  Mallika KERALAPURA ,  John Douglas MARSHALL

    IPC: A61N7/00

    CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

    Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,vi.

    METHODS AND SYSTEMS FOR CONFIRMING FOCUS OF ULTRASOUND BEAMS
    10.
    发明公开
    METHODS AND SYSTEMS FOR CONFIRMING FOCUS OF ULTRASOUND BEAMS 审中-公开

    公开(公告)号：US20240033541A1

    公开(公告)日：2024-02-01

    申请号：US18358295

    申请日：2023-07-25

    Applicant: Cordance Medical Inc.

    Inventor： Bhaskar S. RAMAMURTHY ,  Mallika KERALAPURA ,  John Douglas MARSHALL

    IPC: A61N7/00

    CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0039 ,  A61N2007/0078 ,  A61N2007/0052

    Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,vi.

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