公开(公告)号：US20240307709A1

公开(公告)日：2024-09-19

申请号：US18671236

申请日：2024-05-22

Applicant: Cordance Medical Inc.

Inventor： Bhaskar S. RAMAMURTHY ,  Mallika KERALAPURA ,  John Douglas MARSHALL

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,vi.

公开(公告)号：US20240042242A1

公开(公告)日：2024-02-08

申请号：US18358330

申请日：2023-07-25

Applicant: Cordance Medical Inc.

Inventor： Bhaskar S. RAMAMURTHY ,  Mallika KERALAPURA ,  John Douglas MARSHALL

IPC: A61N7/00 ,  G16H20/40

CPC classification number: A61N7/00 ,  G16H20/40 ,  A61N2007/0078 ,  A61N2007/0004

Abstract: Systems and methods for rapid calculation of parameters for delivering ultrasound energy to selected locations in the brain. An example method for delivering ultrasound energy to a region of a blood-brain barrier may comprise generating a model of the region of the blood-brain barrier and surrounding tissues. The method may also comprise determining a plurality of intermediate parameters by simulating acoustic paths of a plurality of ultrasound beams propagating from the region of the blood-brain barrier to a plurality of locations. The method may also comprise determining transmission parameters for ultrasound beams to be emitted from a plurality of ultrasound transducers based on the intermediate parameters and measured locations of the ultrasound transducers.

公开(公告)号：US20240033541A1

公开(公告)日：2024-02-01

申请号：US18358295

申请日：2023-07-25

Applicant: Cordance Medical Inc.

Inventor： Bhaskar S. RAMAMURTHY ,  Mallika KERALAPURA ,  John Douglas MARSHALL

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0039 ,  A61N2007/0078 ,  A61N2007/0052

Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ϕx,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ϕx,vi.