Process for preparing sodium salts or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylate
    1.
    发明授权
    Process for preparing sodium salts or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylate 有权
    制备4-羟基-2-氧代-2,5-二氢呋喃-3-羧酸钠的钠盐或钾盐的方法

    公开(公告)号:US09056848B2

    公开(公告)日:2015-06-16

    申请号:US14002695

    申请日:2012-02-29

    CPC classification number: C07D307/60 C07D307/68

    Abstract: Process for preparing sodium or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III) which is then reacted further with a chloroacetic ester to give a compound of the formula (V) followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium or potassium alkoxide of the formula ZOR1 where R1, R2, R3 and K are each as defined in the description.

    Abstract translation: 制备4-羟基-2-氧代-2,5-二氢呋喃-3-羧酸酯的钠盐或钾盐的方法,其包括丙二酸酯与氢氧化钾的反应,得到相应的式(III)的丙二酸酯钾盐 ),然后将其与氯乙酸酯进一步反应,得到式(V)化合物,随后闭环反应,其中式(Ⅴ)化合物与式ZOR1的钠或钾醇盐反应,其中R 1 ,R2,R3和K各自如说明书中所定义。

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