公开(公告)号：US20110157592A1

公开(公告)日：2011-06-30

申请号：US12980094

申请日：2010-12-28

Applicant: Jia-Huey Tsao ,  Jau-Jiu Ju ,  Hsueh-Ching Shih ,  Chun-Min Su ,  Hung-Yueh Chen ,  Kuo-Chi Chiu ,  Chih-Cheng Feng ,  Sheng-Li Chang ,  Hsing-Cheng Yu

Inventor： Jia-Huey Tsao ,  Jau-Jiu Ju ,  Hsueh-Ching Shih ,  Chun-Min Su ,  Hung-Yueh Chen ,  Kuo-Chi Chiu ,  Chih-Cheng Feng ,  Sheng-Li Chang ,  Hsing-Cheng Yu

IPC: G01N21/55 ,  G01N1/10

CPC classification number: G01N21/553

Abstract: The present invention provides a surface plasmon resonance (SPR) unit having at least one microfluidic channel with grating structures embedded in so that a grating-coupled surface plasmon resonance can be induced by an incident light while fluid in the microfluidic channel contacts or flows through the grating area. The induced variation of optical signal due to the SPR effect is analyzed for performing bio-screening and assay of bioaffinity reaction. Meanwhile, present invention further provides an SPR inspection system possessing a rotation power to the SPR unit such that the SPR unit is capable of rotating and thereby generating a centrifugal force for driving the flow inside the microfluidic channels so as to achieve the label-free and high throughput SPR inspection system with low-cost.

Abstract translation: 本发明提供一种表面等离子体共振（SPR）单元，其具有至少一个具有嵌入光栅结构的微流体通道，从而可以通过入射光诱导光栅耦合的表面等离子体共振，同时微流体通道中的流体接触或流过 光栅区域。 分析由于SPR效应引起的光信号变化，进行生物亲和反应的生物筛选和测定。 同时，本发明还提供了一种具有向SPR单元的旋转动力的SPR检查系统，使得SPR单元能够旋转，从而产生用于驱动微流体通道内的流动的离心力，从而实现无标签和 高吞吐量SPR检测系统，成本低廉。

公开(公告)号：US07593110B2

公开(公告)日：2009-09-22

申请号：US11937506

申请日：2007-11-09

Applicant: Chih-Cheng Feng ,  Hsueh-Ching Shih ,  Ting-Hsuan Chen

Inventor： Chih-Cheng Feng ,  Hsueh-Ching Shih ,  Ting-Hsuan Chen

IPC: G01N27/30

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N33/54373 ,  G01N2021/035

Abstract: A surface plasmon resonance (SPR) detecting apparatus which controls the flow of fluid without using an additional pressure difference or pump is provided. The SPR detecting apparatus includes a detection chip, a fluid driving chip and an optical device. The fluid driving chip has a plurality of electrodes disposed on the flow space of the fluid. The angle between the liquid and a contact surface is changed by electrifying the electrodes, and the electrodes are turned on and turned off sequentially such that the droplets are controlled to move. The optical device is used to detect surface plasmon resonance phenomenon and to determine the interaction of the droplets and the detecting chip.

Abstract translation: 提供了一种在不使用附加压力差或泵的情况下控制流体流动的表面等离子体共振（SPR）检测装置。 SPR检测装置包括检测芯片，流体驱动芯片和光学装置。 流体驱动芯片具有设置在流体的流动空间上的多个电极。 通过使电极通电来改变液体和接触表面之间的角度，并且电极被依次打开和关闭，使得液滴被控制移动。 光学装置用于检测表面等离子体共振现象并确定液滴和检测芯片的相互作用。

公开(公告)号：US20120083704A1

公开(公告)日：2012-04-05

申请号：US12956938

申请日：2010-11-30

Applicant: Chih-Cheng Feng ,  James Hung ,  Fu-Jung Hsiao ,  Kuo-Hung Chan

Inventor： Chih-Cheng Feng ,  James Hung ,  Fu-Jung Hsiao ,  Kuo-Hung Chan

IPC: A61B5/022

CPC classification number: A61B5/02225

Abstract: A method and device for blood pressure measurement is disclosed. The steps are capturing the pressure oscillating signal detected from the pressure sensor arranged at the cuff, processing the signal appropriately to cooperate with the personal information inputted by subject or without inputting any information, and actively selecting suitable characteristic coefficient accurately determine the systolic blood pressure and the diastolic blood pressure. It is able to adaptively regulate algorithms relative to different ages, BMIs, medical histories, and further accurately determine the blood pressure, so that the probability of the sphygmomanometer's erroneous judgment is decreased, medical resources are saved, and further a personal blood pressure measurement is accurately performed.

Abstract translation: 公开了一种用于血压测量的方法和装置。 步骤是捕获从布置在袖带处的压力传感器检测到的压力振荡信号，适当地处理该信号以配合由被摄体输入的个人信息或不输入任何信息，并且主动选择合适的特征系数精确地确定收缩压和 舒张压。 能够自适应地调整相对于不同年龄，BMI，医疗历史的算法，并进一步准确地确定血压，从而降低血压计错误判断的可能性，节省医疗资源，进一步进行个人血压测量 准确执行。

公开(公告)号：US20120307248A1

公开(公告)日：2012-12-06

申请号：US13304697

申请日：2011-11-28

Applicant: Hsueh-Ching Shih ,  Kun-Chih Tsai ,  Chih-Cheng Feng ,  Jia-Huey Tsao ,  Chun-Min Su

Inventor： Hsueh-Ching Shih ,  Kun-Chih Tsai ,  Chih-Cheng Feng ,  Jia-Huey Tsao ,  Chun-Min Su

IPC: G01N21/55 ,  G01N27/447

CPC classification number: G01N21/553 ,  G01N21/07 ,  G01N21/648

Abstract: A liquid transporting device using electrowetting on dielectric technique is provided. A sampling liquid is accurately transported on a substrate in a channel-free manner. The sampling liquid is spun off the substrate by a centrifugal force after the sampling liquid has been detected. The liquid transporting device can be applied to a biochemical detecting apparatus and a biochemical detecting method, thereby fulfilling requirements of accurate sample transportation in the biomedical field. The liquid transporting device is simplified to reduce overall costs, thus being helpful for decreasing high prices of biomedical detecting systems.

Abstract translation: 提供了使用电润湿介质技术的液体输送装置。 采样液体以无通道的方式在衬底上精确地传送。 检测出取样液后，采用离心力将取样液从基板上剥离出来。 液体输送装置可应用于生物化学检测装置和生物化学检测方法，从而满足生物医学领域精确样品运输的要求。 液体输送装置被简化以降低整体成本，从而有助于降低生物医学检测系统的高价格。

公开(公告)号：US08189183B2

公开(公告)日：2012-05-29

申请号：US12580619

申请日：2009-10-16

Applicant: Hsueh-Ching Shih ,  Jia-Huey Tsao ,  Chih-Cheng Feng ,  Chun-Lin Chiang ,  Chun-Min Su ,  Kuo-Chi Chiu

Inventor： Hsueh-Ching Shih ,  Jia-Huey Tsao ,  Chih-Cheng Feng ,  Chun-Lin Chiang ,  Chun-Min Su ,  Kuo-Chi Chiu

IPC: G01N21/01 ,  G01N21/55 ,  G01M19/00

CPC classification number: G01N21/553 ,  G01N21/01

Abstract: An optical inspection apparatus capable of adjusting an incident angle of a detected light beam and adjusting a detecting angle for detecting the detected light beam. A driving mechanism is used to actuate two arms having a light source and a detector disposed thereon respectively to conduct a relative movement between the two arms so as to control the incident angle and the detecting angle. By means of the embodiments, mechanism for adjusting the angle is simplified so that the apparatus is capable of being adapted to combine with the application of micro sensors such that practicality of modularization design and microminiaturization and convenience of operation are capable of being greatly improved and that the cost can be reduced.

Abstract translation: 一种光学检查装置，其能够调整检测光束的入射角度并调整检测角度以检测检测到的光束。 驱动机构用于致动具有光源的两个臂和分别布置在其上的检测器，以在两个臂之间进行相对移动，以便控制入射角和检测角度。 通过这些实施例，简化了用于调节角度的机构，使得该装置能够适应于微型传感器的应用，使得模块化设计和微型化以及操作方便性的实用性能够大大提高，并且 可以降低成本。

公开(公告)号：US20100253947A1

公开(公告)日：2010-10-07

申请号：US12580619

申请日：2009-10-16

Applicant: HSUEH-CHING SHIH ,  JIA-HUEY TSAO ,  CHIH-CHENG FENG ,  CHUN-LIN CHIANG ,  CHUN-MIN SU ,  KUO-CHI CHU

Inventor： HSUEH-CHING SHIH ,  JIA-HUEY TSAO ,  CHIH-CHENG FENG ,  CHUN-LIN CHIANG ,  CHUN-MIN SU ,  KUO-CHI CHU

IPC: G01N21/01 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/01

Abstract: An optical inspection apparatus capable of adjusting an incident angle of a detected light beam and adjusting a detecting angle for detecting the detected light beam. A driving mechanism is used to actuate two arms having a light source and a detector disposed thereon respectively to conduct a relative movement between the two arms so as to control the incident angle and the detecting angle. By means of the embodiments, mechanism for adjusting the angle is simplified so that the apparatus is capable of being adapted to combine with the application of micro sensors such that practicality of modularization design and microminiaturization and convenience of operation are capable of being greatly improved and that the cost can be reduced.

Abstract translation: 一种光学检查装置，其能够调整检测光束的入射角度并调整检测角度以检测检测到的光束。 驱动机构用于致动具有光源的两个臂和分别布置在其上的检测器，以在两个臂之间进行相对移动，以便控制入射角和检测角度。 通过这些实施例，简化了用于调节角度的机构，使得该装置能够适应于微型传感器的应用，使得模块化设计和微型化以及操作方便性的实用性能够大大提高，并且 可以降低成本。

公开(公告)号：US08261626B2

公开(公告)日：2012-09-11

申请号：US12272119

申请日：2008-11-17

Applicant: Jhe-Kun Liou ,  Chih-Cheng Feng ,  Chun-Lin Yu

Inventor： Jhe-Kun Liou ,  Chih-Cheng Feng ,  Chun-Lin Yu

IPC: F16H1/24

CPC classification number: F16H25/2219 ,  F16H25/2214 ,  Y10T74/19702 ,  Y10T74/19767 ,  Y10T74/19772 ,  Y10T74/19777

Abstract: A ball screw comprises a shaft, a nut, two return elements, plural rolling elements and a sleeve. When being rotated, the shaft will drive the nut to move and circulate the rolling elements within a circulation path defined by a loaded path and the return passages of the return elements. The nut is provided with a circular groove in an outer circumferential surface thereof, and the sleeve is disposed in the circular groove. The sleeve is provided with plural push grooves in an inner circumferential surface thereof, and there is an angular difference between a rolling passage in the nut and the respective push grooves, and the push grooves cooperate with the rolling elements which pass through the rolling passage. By such arrangements, the push grooves of the sleeve will be pushed by the rolling elements to convert the linear motion into rotary motion, thus making the sleeve rotate.

Abstract translation: 滚珠丝杠包括轴，螺母，两个返回元件，多个滚动元件和套筒。 当旋转时，轴将驱动螺母以使滚动元件在由加载路径和返回元件的返回通道限定的循环路径内移动和循环。 螺母在其外周面上设置有圆形槽，并且套筒设置在圆形槽中。 套筒在其内周面上设置有多个推动槽，并且在螺母中的滚动通道和各个推动槽之间存在角度差，并且推动槽与通过滚动通道的滚动元件配合。 通过这样的布置，套筒的推动槽将被滚动元件推动，以将线性运动转换为旋转运动，从而使套筒旋转。

公开(公告)号：US20100122597A1

公开(公告)日：2010-05-20

申请号：US12272119

申请日：2008-11-17

Applicant: Jhe-Kun Liou ,  Chih-cheng Feng ,  Chun-lin Yu

Inventor： Jhe-Kun Liou ,  Chih-cheng Feng ,  Chun-lin Yu

IPC: F16H1/24

CPC classification number: F16H25/2219 ,  F16H25/2214 ,  Y10T74/19702 ,  Y10T74/19767 ,  Y10T74/19772 ,  Y10T74/19777

Abstract: A ball screw comprises a shaft, a nut, two return elements, plural rolling elements and a sleeve. When being rotated, the shaft will drive the nut to move and circulate the rolling elements within a circulation path defined by a loaded path and the return passages of the return elements. The nut is provided with a circular groove in an outer circumferential surface thereof, and the sleeve is disposed in the circular groove. The sleeve is provided with plural push grooves in an inner circumferential surface thereof, and there is an angular difference between a rolling passage in the nut and the respective push grooves, and the push grooves cooperate with the rolling elements which pass through the rolling passage. By such arrangements, the push grooves of the sleeve will be pushed by the rolling elements to convert the linear motion into rotary motion, thus making the sleeve rotate.

Abstract translation: 滚珠丝杠包括轴，螺母，两个返回元件，多个滚动元件和套筒。 当旋转时，轴将驱动螺母以使滚动元件在由加载路径和返回元件的返回通道限定的循环路径内移动和循环。 螺母在其外周面上设置有圆形槽，并且套筒设置在圆形槽中。 套筒在其内周面上设置有多个推动槽，并且在螺母中的滚动通道和各个推动槽之间存在角度差，并且推动槽与通过滚动通道的滚动元件配合。 通过这样的布置，套筒的推动槽将被滚动元件推动，以将线性运动转换为旋转运动，从而使套筒旋转。

公开(公告)号：US20090097032A1

公开(公告)日：2009-04-16

申请号：US11937506

申请日：2007-11-09

Applicant: Chih-Cheng Feng ,  Hsueh-Ching Shih ,  Ting-Hsuan Chen

Inventor： Chih-Cheng Feng ,  Hsueh-Ching Shih ,  Ting-Hsuan Chen

IPC: G01N27/30 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N33/54373 ,  G01N2021/035

Abstract: A surface plasmon resonance (SPR) detecting apparatus which controls the flow of fluid without using an additional pressure difference or pump is provided. The SPR detecting apparatus includes a detection chip, a fluid driving chip and an optical device. The fluid driving chip has a plurality of electrodes disposed on the flow space of the fluid. The angle between the liquid and a contact surface is changed by electrifying the electrodes, and the electrodes are turned on and turned off sequentially such that the droplets are controlled to move. The optical device is used to detect surface plasmon resonance phenomenon and to determine the interaction of the droplets and the detecting chip.

Abstract translation: 提供了一种在不使用附加压力差或泵的情况下控制流体流动的表面等离子体共振（SPR）检测装置。 SPR检测装置包括检测芯片，流体驱动芯片和光学装置。 流体驱动芯片具有设置在流体的流动空间上的多个电极。 通过使电极通电来改变液体和接触表面之间的角度，并且电极被依次打开和关闭，使得液滴被控制移动。 光学装置用于检测表面等离子体共振现象并确定液滴和检测芯片的相互作用。