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公开(公告)号：US08013019B2
公开(公告)日：2011-09-06
申请号：US12828762
申请日：2010-07-01
申请人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
发明人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
IPC分类号： A61K31/18 , A61K31/472
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US07767715B2
公开(公告)日：2010-08-03
申请号：US12420206
申请日：2009-04-08
申请人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
发明人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
IPC分类号： A61K31/18 , A61K31/472
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20100016366A1
公开(公告)日：2010-01-21
申请号：US12496001
申请日：2009-07-01
IPC分类号： A61K31/445 , C07D211/94
CPC分类号： C07D211/46
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱拮抗剂和含有它们的药物组合物。
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公开(公告)号：US07629358B2
公开(公告)日：2009-12-08
申请号：US11083265
申请日：2005-03-16
申请人： Alan Daniel Brown , Charlotte Alice Louise Lane , Paul Alan Glossop , David Anthony Price , Russell Andrew Lewthwaite , Mark Edward Bunnage , Kim James , Graham Lunn
发明人： Alan Daniel Brown , Charlotte Alice Louise Lane , Paul Alan Glossop , David Anthony Price , Russell Andrew Lewthwaite , Mark Edward Bunnage , Kim James , Graham Lunn
IPC分类号： A61K31/47 , A61K31/165 , C07D217/00 , C07C237/00
CPC分类号： C07D217/06 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C311/46 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/74 , C07D213/40 , C07D235/14 , C07D239/26 , C07D295/088 , C07D295/13 , C07D295/26
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20080312235A1
公开(公告)日：2008-12-18
申请号：US11572533
申请日：2005-07-12
IPC分类号： A61K31/5377 , C07D401/12 , A61P25/00
CPC分类号： C07D213/81 , C07D401/12
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其制备方法，用于制备的中间体和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途 。
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公开(公告)号：US07268147B2
公开(公告)日：2007-09-11
申请号：US10840770
申请日：2004-05-06
申请人： Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite
发明人： Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite
IPC分类号： A61K31/47 , A61K31/4439 , C07D217/02
CPC分类号： C07D213/75 , C07C237/20 , C07C237/22 , C07C311/46 , C07C2602/08 , C07D209/44 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US07649004B2
公开(公告)日：2010-01-19
申请号：US11572533
申请日：2005-07-12
IPC分类号： A61K31/5377 , A61K31/44 , C07D401/12 , C07D413/12
CPC分类号： C07D213/81 , C07D401/12
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其制备方法，用于制备的中间体和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途 。
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公开(公告)号：US20090197912A1
公开(公告)日：2009-08-06
申请号：US12420206
申请日：2009-04-08
申请人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
发明人： Alan Daniel Brown , Mark Edward Bunnage , Paul Alan Glossop , Kim James , Charlotte Alice Louise Lane , Russel Andrew Lewthwaite , Ian Brian Moses , David Anthony Price , Nicholas Murray Thomson
IPC分类号： A61K31/472 , A61K31/18 , A61P11/00
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US07547731B2
公开(公告)日：2009-06-16
申请号：US11773012
申请日：2007-07-03
申请人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
发明人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
IPC分类号： A61K31/167 , C07C233/24
CPC分类号： C07C237/20 , C07C237/30 , C07C237/32 , C07C255/60 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D209/48 , C07D211/32 , C07D213/38 , C07D213/40 , C07D217/06 , C07D217/16 , C07D221/22 , C07D221/24 , C07D295/192 , C07D335/02
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US07538141B2
公开(公告)日：2009-05-26
申请号：US11086132
申请日：2005-03-21
申请人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
发明人： Alan Daniel Brown , Mark Edward Bunnage , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Paul Alan Glossop , Kim James , David Anthony Price
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A01N37/18 , A61K31/16
CPC分类号： C07C237/20 , C07C237/30 , C07C255/60 , C07C311/46 , C07C323/41 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D211/58 , C07D213/40 , C07D213/75 , C07D217/06 , C07D231/40 , C07D413/04
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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