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公开(公告)号:US08278417B2
公开(公告)日:2012-10-02
申请号:US13442943
申请日:2012-04-10
申请人: Vivienne S. Marshall , Charlotte A. Smith , Catherine J. Trumpower , George L. Sing , Linda O. Palladino
发明人: Vivienne S. Marshall , Charlotte A. Smith , Catherine J. Trumpower , George L. Sing , Linda O. Palladino
CPC分类号: A61K38/57 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K2300/00
摘要: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
摘要翻译: 本发明涉及新型含细胞因子的溶液组合物(本文中称为CFS组合物),包括新型含缓释细胞因子的溶液组合物(本文称为SR-CFS组合物),制备这种新型组合物的方法和 其用途。
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公开(公告)号:US20130040880A1
公开(公告)日:2013-02-14
申请号:US13653840
申请日:2012-10-17
申请人: Vivienne S. Marshall , Catherine J. Trumpower , Charlotte A. Smith , George L. Sing , Linda O. Palladino
发明人: Vivienne S. Marshall , Catherine J. Trumpower , Charlotte A. Smith , George L. Sing , Linda O. Palladino
CPC分类号: A61K38/57 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K2300/00
摘要: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
摘要翻译: 本发明涉及新型含细胞因子的溶液组合物(本文中称为CFS组合物),包括新型含缓释细胞因子的溶液组合物(本文称为SR-CFS组合物),制备这种新型组合物的方法和 其用途。
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公开(公告)号:US20120238495A1
公开(公告)日:2012-09-20
申请号:US13443000
申请日:2012-04-10
CPC分类号: A61K38/57 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K2300/00
摘要: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
摘要翻译: 本发明涉及新的含细胞因子的溶液组合物(本文中称为“CFS”组合物),包括新的含缓释细胞因子的溶液组合物(本文称为“SR-CFS”组合物),制备方法 这些新颖的组合物和用途。
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公开(公告)号:US08198239B2
公开(公告)日:2012-06-12
申请号:US13373458
申请日:2011-11-15
CPC分类号: A61K38/57 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K2300/00
摘要: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
摘要翻译: 本发明涉及新的含细胞因子的溶液组合物(本文中称为“CFS”组合物),包括新的含缓释细胞因子的溶液组合物(本文称为“SR-CFS”组合物),制备方法 这些新颖的组合物和用途。
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5.
公开(公告)号:US20100068180A1
公开(公告)日:2010-03-18
申请号:US12448903
申请日:2008-01-11
IPC分类号: A61K39/395 , A61K35/12 , A61K38/21 , A61P37/06 , A61P29/00
CPC分类号: C12N5/0636 , C12N5/0605 , C12N2501/23 , C12N2502/02
摘要: The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
摘要翻译: 本发明涉及用于调节炎症和/或免疫应答的新方法。 这种方法利用包括但不限于胚胎外HLA-G阳性细胞(本文中称为EHP细胞)和羊膜来源的多潜能祖细胞(本文称为AMP细胞)的外胚细胞(本文称为EE细胞)的组合物; 包含扩增的EE细胞群体和/或细胞裂解物和/或由其衍生的条件培养基的组合物,彼此或彼此组合和/或与各种细胞外基质和/或装置和/或其它合适的活性剂组合。
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公开(公告)号:US08506949B2
公开(公告)日:2013-08-13
申请号:US13483369
申请日:2012-05-30
CPC分类号: A61K35/50 , A61K9/08 , A61K35/12 , A61K38/1709 , A61K38/19 , A61K38/21 , A61K39/001 , A61K39/3955 , A61K45/06 , A61K2039/5158 , C12N5/0634 , C12N2502/025
摘要: The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
摘要翻译: 本发明涉及用于调节炎症和/或免疫应答的新方法。 这种方法利用包括但不限于胚胎外HLA-G阳性细胞(本文中称为EHP细胞)和羊膜来源的多潜能祖细胞(本文称为AMP细胞)的外胚细胞(本文称为EE细胞)的组合物; 包含扩增的EE细胞群体和/或细胞裂解物和/或由其衍生的条件培养基的组合物,彼此或彼此组合和/或与各种细胞外基质和/或装置和/或其它合适的活性剂组合。
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公开(公告)号:US20130071363A1
公开(公告)日:2013-03-21
申请号:US13644026
申请日:2012-10-03
CPC分类号: A61K35/50 , A61K8/982 , A61K35/12 , A61K2800/10 , A61Q19/00 , C12N5/0605 , C12N5/0629 , C12N2501/11 , C12N2502/02
摘要: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
摘要翻译: 本发明涉及基本上纯化的羊膜来源的细胞群,包含基本上纯化的羊膜来源的细胞群的组合物,以及产生这种基本上纯化的羊膜来源的细胞群的方法以及使用方法。 本发明还涉及结合羊膜来源的细胞或者另一种或多种羊膜来源的细胞表面蛋白质标记的抗体,特别是单克隆抗体。 本发明还涉及生产抗体的方法,使用抗体的方法和包含抗体的试剂盒。
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公开(公告)号:US20120264106A1
公开(公告)日:2012-10-18
申请号:US13483346
申请日:2012-05-30
IPC分类号: C12N5/078
CPC分类号: A61K35/50 , A61K9/08 , A61K35/12 , A61K38/1709 , A61K38/19 , A61K38/21 , A61K39/001 , A61K39/3955 , A61K45/06 , A61K2039/5158 , C12N5/0634 , C12N2502/025
摘要: The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
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公开(公告)号:US20120225815A1
公开(公告)日:2012-09-06
申请号:US13442964
申请日:2012-04-10
CPC分类号: A61K38/57 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K2300/00
摘要: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
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公开(公告)号:US20100080779A1
公开(公告)日:2010-04-01
申请号:US12592658
申请日:2009-12-01
CPC分类号: A61K35/50 , A61K35/12 , C12N5/0605 , C12N5/0629 , C12N2501/11 , C12N2502/02
摘要: The invention is directed to methods for the treatment of wounds. Such methods utilize novel compositions, including but not limited to amnion-derived multipotent cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine suspension or ACCS), cell lysates derived therefrom, cell products derived therefrom, each alone or in combination.
摘要翻译: 本发明涉及治疗伤口的方法。 这些方法利用新的组合物,包括但不限于羊膜来源的多潜能细胞(本文称为AMP细胞),由其衍生的条件培养基(本文称为羊膜来源的细胞细胞因子悬浮液或ACCS),由其衍生的细胞裂解物,细胞 从其衍生的产物,各自单独或组合。
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